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Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development

  • Authors:
    • Xiongfei Wang
    • Xun He
    • Tianfu Li
    • Yousheng Shu
    • Songtao Qi
    • Guoming Luan
  • View Affiliations / Copyright

    Affiliations: Beijing Key Laboratory of Epilepsy, Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China, Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Beijing Key Laboratory of Epilepsy, Brain Research Institute, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China, State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, School of Brain and Cognitive Sciences, The Collaborative Innovation Center for Brain Science, Beijing Normal University, Beijing 100875, P.R. China, Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5757-5766
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    Published online on: October 16, 2017
       https://doi.org/10.3892/etm.2017.5311
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Abstract

Ifenprodil has been demonstrated to reduce spontaneous action potentials observed by local field potential in animal models. To investigate whether ifenprodil exerts an anti‑epileptic effect on neuronal levels in humans, whole‑cell patch clamp recordings were used to study the electrophysiological membrane properties of neocortical pyramidal neurons in human brain tissues. Electrophysiological membrane properties and spontaneous spikes of neocortical pyramidal neurons were investigated by using whole‑cell patch clamp recordings, prior to and following the application of ifenprodil. In the present study, ifenprodil significantly decreased the membrane input resistance (P<0.01), membrane time constant (P<0.01), action potential amplitude (P<0.01), action potential rising rate (P<0.05) and falling rate (P<0.05) on neocortical pyramidal neurons in patients with epilepsy caused by malformations of cortical development (MCD). These results suggested that ifenprodil decreased neuronal excitability of neocortical pyramidal neurons in patients with epilepsy and MCD and demonstrated that ifenprodil may be a potentially specific treatment for refractory epilepsy caused by MCD.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, He X, Li T, Shu Y, Qi S and Luan G: Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development. Exp Ther Med 14: 5757-5766, 2017.
APA
Wang, X., He, X., Li, T., Shu, Y., Qi, S., & Luan, G. (2017). Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development. Experimental and Therapeutic Medicine, 14, 5757-5766. https://doi.org/10.3892/etm.2017.5311
MLA
Wang, X., He, X., Li, T., Shu, Y., Qi, S., Luan, G."Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development". Experimental and Therapeutic Medicine 14.6 (2017): 5757-5766.
Chicago
Wang, X., He, X., Li, T., Shu, Y., Qi, S., Luan, G."Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5757-5766. https://doi.org/10.3892/etm.2017.5311
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, He X, Li T, Shu Y, Qi S and Luan G: Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development. Exp Ther Med 14: 5757-5766, 2017.
APA
Wang, X., He, X., Li, T., Shu, Y., Qi, S., & Luan, G. (2017). Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development. Experimental and Therapeutic Medicine, 14, 5757-5766. https://doi.org/10.3892/etm.2017.5311
MLA
Wang, X., He, X., Li, T., Shu, Y., Qi, S., Luan, G."Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development". Experimental and Therapeutic Medicine 14.6 (2017): 5757-5766.
Chicago
Wang, X., He, X., Li, T., Shu, Y., Qi, S., Luan, G."Anti‑epileptic effect of ifenprodil on neocortical pyramidal neurons in patients with malformations of cortical development". Experimental and Therapeutic Medicine 14, no. 6 (2017): 5757-5766. https://doi.org/10.3892/etm.2017.5311
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