Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway

  • Authors:
    • Li Liu
    • Li Chen
    • Caixia Jiang
    • Jing Guo
    • Yan Xie
    • Le Kang
    • Zhongping Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China
  • Pages: 6125-6130
    |
    Published online on: October 16, 2017
       https://doi.org/10.3892/etm.2017.5316
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A previous study by our group has demonstrated that lipopolysaccharide (LPS) induces adenomyosis through stimulating inflammatory cell proliferation and invasive growth of stromal cells via Toll‑like receptor 4 (TLR4) signaling. The present study aimed to investigate the effects of berberine (BBR) on LPS‑induced ectopic endometrial stromal cells (EESCs) isolated from patients with adenomyosis. The viability of EESCs treated with LPS or LPS plus BBR was detected by a cell counting kit‑8 assay, and the cell cycle distribution and apoptosis were evaluated by flow cytometry. The effect of BBR on the expression of key molecules of inflammatory proliferation and invasive growth of LPS‑induced EESCs was also evaluated. BBR significantly inhibited the LPS‑induced proliferation of EESCs in a dose‑ and time‑dependent manner. BBR induced cell cycle arrest in G0/G1 phase and enhanced apoptosis of LPS‑induced EESCs. Furthermore, BBR inhibited the expression of interleukin (IL)‑6, IL‑8, transforming growth factor‑β, epithelial growth factor, vascular endothelial growth factor and matrix metalloproteinase 2 in LPS‑induced EESCs. To the best of our knowledge, the present study was the first to demonstrate that BBR has a protective effect on ameliorating the LPS‑induced progression of adenomyosis. This result may provide a novel therapeutic strategy for the clinical treatment of the disease
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Harvey J and Warwick I: Endometriosis. BMJ. 340:c26612010. View Article : Google Scholar : PubMed/NCBI

2 

Korzekwa A, Łupicka M, Socha B, Mannelli Ch and Skarzynski DJ: Is adenomyosis a problem in reproduction and fertility? Pol J Vet Sci. 17:187–194. 2014.PubMed/NCBI

3 

Farquhar C and Brosens I: Medical and surgical management of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 20:603–616. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Lousse JC, Van Langendonckt A, Defrere S, Ramos RG, Colette S and Donnez J: Peritoneal endometriosis is an inflammatory disease. Front Biosci (Elite Ed). 4:23–40. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Sheldon IM and Bromfield JJ: Innate immunity in the human endometrium and ovary. Am J Reprod Immunol. 66 Suppl 1:S63–S71. 2011. View Article : Google Scholar

6 

Bertschi D, McKinnon BD, Evers J, Bersinger NA and Mueller MD: Enhanced inflammatory activity of endometriotic lesions from the rectovaginal septum. Mediators Inflamm. 2013:4509502013. View Article : Google Scholar : PubMed/NCBI

7 

Guo J, Chen L, Luo N, Li C, Chen R, Qu X, Liu M, Kang L and Cheng Z: LPS/TLR4-mediated stromal cells acquire an invasive phenotype and are implicated in the pathogenesis of adenomyosis. Sci Rep. 6:214162016. View Article : Google Scholar : PubMed/NCBI

8 

Pan L, Wang W, Shi F, Zhou J, Zhang M, Zhu H and Zeng M: Exploratory pharmacokinetics of Geniposide in rat model of cerebral ischemia orally administered with or without Baicalin and/or Berberine. Evid Based Complement Alternat Med. 2013:3495312013. View Article : Google Scholar : PubMed/NCBI

9 

Sun Y, Xun K, Wang Y and Chen X: A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs. 20:757–769. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kong WJ, Zhang H, Song DQ, Xue R, Zhao W, Wei J, Wang YM, Shan N, Zhou ZX, Yang P, et al: Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism. 58:109–119. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Singh IP and Mahajan S: Berberine and its derivatives: A patent review (2009–2012). Expert Opin Ther Pat. 23:215–231. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Yin J, Zhang H and Ye J: Traditional chinese medicine in treatment of metabolic syndrome. Endoc Metab Immune Disord Drug Targets. 8:99–111. 2008. View Article : Google Scholar

13 

Jin P, Zhang C and Li N: Berberine exhibits antitumor effects in human ovarian cancer cells. Anticancer Agents Med Chem. 15:511–516. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Cao B, Liu X, Fu X, Xiong Z, Chen L, Sartor O, Dong Y and Zhang H: Berberine suppresses androgen receptor signaling in prostate cancer. Mol Cancer Ther. 10:1346–1356. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, et al: Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 55:2256–2264. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Chen Q, Qin R, Fang Y and Li H: Berberine sensitizes human ovarian cancer cells to cisplatin through miR-93/PTEN/Akt signaling pathway. Cell Physiol Biochem. 36:956–965. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Marverti G, Ligabue A, Lombardi P, Ferrari S, Monti MG, Frassineti C and Costi MP: Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells. Int J Oncol. 43:1269–1280. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Exacoustos C, Manganaro L and Zupi E: Imaging for the evaluation of endometriosis and adenomyosis. Best Pract Res Clin Obst Gynaecol. 28:655–681. 2014. View Article : Google Scholar

19 

Rajaei S, Mirahmadian M, Jeddi-Tehrani M, Tavakoli M, Zonoobi M, Dabbagh A and Zarnani AH: Effect of 1,25(OH)2 vitamin D3 on cytokine production by endometrial cells of women with repeated implantation failure. Gynecol Endocrinol. 28:906–911. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Wan L, Zou Y, Wan LH, Wang LQ, Huang MZ, Wu J, Zhu YB and Huang OP: Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3zeta downregulation. Arch Gynecol Obstet. 292:1301–1309. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Yang JH, Wu MY, Chen CD, Chen MJ, Yang YS and Ho HN: Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis. Hum Reprod. 22:945–952. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Bruse C, Guan Y, Carlberg M, Carlström K and Bergqvist A: Basal release of urokinase plasminogen activator, plasminogen activator inhibitor-1, and soluble plasminogen activator receptor from separated and cultured endometriotic and endometrial stromal and epithelial cells. Fertil Steril. 83 Suppl 1:S1155–S1160. 2005. View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Miller SI, Ernst RK and Bader MW: LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol. 3:36–46. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Lu YC, Yeh WC and Ohashi PS: LPS/TLR4 signal transduction pathway. Cytokine. 42:145–151. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Azuma Y, Taniguchi F, Nakamura K, Nagira K, Khine YM, Kiyama T1, Uegaki T, Izawa M and Harada T: Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway. Am J Reprode Immunol. 77:2017.

27 

Allhorn S, Böing C, Koch AA, Kimmig R and Gashaw I: TLR3 and TLR4 expression in healthy and diseased human endometrium. Reprod Biol Endocrinol. 6:402008. View Article : Google Scholar : PubMed/NCBI

28 

Chu M, Ding R, Chu ZY, Zhang MB, Liu XY, Xie SH, Zhai YJ and Wang YD: Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor. BMC Complement Alternat Med. 14:892014. View Article : Google Scholar

29 

Huang LH, Pan XP, Gong KR and Shao G: Anti-inflammatory effects of three kinds of traditional Mongolian medicine monomer and its combination on LPS-stimulated RAW264.7 macrophages. Eur Rev Med Pharmacol Sci. 20:950–958. 2016.PubMed/NCBI

30 

Li HM, Wang YY, Wang HD, Cao WJ, Yu XH, Lu DX, Qi RB, Hu CF and Yan YX: Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms. Acta Pharmacol Sin. 32:1364–1372. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Benagiano G, Brosens I and Habiba M: Structural and molecular features of the endomyometrium in endometriosis and adenomyosis. Hum Reprod Update. 20:386–402. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Yang JH, Chen MJ, Wu MY, Chen YC, Yang YS and Ho HN: Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis. Fertil Steril. 86:1459–1465. 2006. View Article : Google Scholar : PubMed/NCBI

33 

May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH and Becker CM: Peripheral biomarkers of endometriosis: A systematic review. Hum Reprod Update. 16:651–674. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Younis A, Hawkins K, Mahini H, Butler W and Garelnabi M: Serum tumor necrosis factor-α, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility. J Assist Reprod Genet. 31:1445–1451. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Khan KN, Masuzaki H, Fujishita A, Kitajima M, Hiraki K, Sekine I, Matsuyama T and Ishimaru T: Interleukin-6- and tumour necrosis factor alpha-mediated expression of hepatocyte growth factor by stromal cells and its involvement in the growth of endometriosis. Hum Reprod. 20:2715–2723. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Sotnikova N, Antsiferova I and Malyshkina A: Cytokine network of eutopic and ectopic endometrium in women with adenomyosis. Am J Reprod Immunol. 47:251–255. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Omwandho CO, Konrad L, Halis G, Oehmke F and Tinneberg HR: Role of TGF-betas in normal human endometrium and endometriosis. Hum Reprod. 25:101–109. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Kang S, Zhao J, Liu Q, Zhou R, Wang N and Li Y: Vascular endothelial growth factor gene polymorphisms are associated with the risk of developing adenomyosis. Environ Mol Mutagen. 50:361–366. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Yang JH, Wu MY, Chen MJ, Chen SU, Yang YS and Ho HN: Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis. Fertil Steril. 91 5 Suppl:2193–2198. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Yi KW, Kim SH, Ihm HJ, Oh YS, Chae HD, Kim CH and Kang BM: Increased expression of p21-activated kinase 4 in adenomyosis and its regulation of matrix metalloproteinase-2 and −9 in endometrial cells. Fertil Steril. 103:1089–1097.e2. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Weigel MT, Krämer J, Schem C, Wenners A, Alkatout I, Jonat W, Maass N and Mundhenke C: Differential expression of MMP-2, MMP-9 and PCNA in endometriosis and endometrial carcinoma. Eur J Obstet Gynecol Reprod Biol. 160:74–78. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu L, Chen L, Jiang C, Guo J, Xie Y, Kang L and Cheng Z: Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Exp Ther Med 14: 6125-6130, 2017.
APA
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., & Cheng, Z. (2017). Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Experimental and Therapeutic Medicine, 14, 6125-6130. https://doi.org/10.3892/etm.2017.5316
MLA
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., Cheng, Z."Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway". Experimental and Therapeutic Medicine 14.6 (2017): 6125-6130.
Chicago
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., Cheng, Z."Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6125-6130. https://doi.org/10.3892/etm.2017.5316
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Chen L, Jiang C, Guo J, Xie Y, Kang L and Cheng Z: Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Exp Ther Med 14: 6125-6130, 2017.
APA
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., & Cheng, Z. (2017). Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Experimental and Therapeutic Medicine, 14, 6125-6130. https://doi.org/10.3892/etm.2017.5316
MLA
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., Cheng, Z."Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway". Experimental and Therapeutic Medicine 14.6 (2017): 6125-6130.
Chicago
Liu, L., Chen, L., Jiang, C., Guo, J., Xie, Y., Kang, L., Cheng, Z."Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6125-6130. https://doi.org/10.3892/etm.2017.5316
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team