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Effects of CASZI on bronchopulmonary development of neonatal rats

  • Authors:
    • Liping Xu
    • Ruifang Tong
    • Xiangnan Li
    • Lihong Liang
    • Han Huang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Children's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Respiratory Medicine, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6243-6246
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/etm.2017.5346
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Abstract

The effect of CASZI on bronchopulmonary development in neonatal rats was investigated. Forty SD rats were randomly divided into the control group (n=20) and the experimental group (n=20) using a random number table. The experimental group was treated with hyperoxia to establish the bronchopulmonary dysplasia (BPD) model, while the control group received no treatment. At 14 days of experiment, rats in each group were treated, and lung tissues were taken for hematoxylin and eosin (H&E) staining. Radial alveolar count (RAC) and morphological changes in lung tissues were observed under a microscope, and the thickness of respiratory membrane was detected via IPP6 image. Reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were used to detect the expression levels of CASZI, Rho kinase, RhoA and ET-A receptor in lung tissues. There were no obviously pathological changes in lung tissues of neonatal rats in the control group, while BPD could be seen in lung tissue structures of neonatal rats in the experimental group. RAC in experimental group was significantly lower than that in the control group (P<0.05), and the thickness of respiratory membrane was significantly higher than that in the control group (P<0.05). CASZI mRNA expression level in the experimental group was significantly lower than that in control group (P<0.05), and Rho kinase, RhoA and ET-A receptor mRNA expression levels were significantly higher than those in the control group (P<0.05). CASZI protein expression level in the experimental group was significantly lower than that in the control group (P<0.05), and the Rho kinase, RhoA and ET-A receptor protein expression levels were significantly higher than those in the control group (P<0.05). In conclusion, CASZI expression was downregulated during the development of BPD. CASZI downregulation may have an effect on the pulmonary microvascular regeneration through RhoA/ROCK signaling pathway, thus participating in the pathogenesis of BPD.
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1 

Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH and Baker CD: Retrospective analysis of an interdisciplinary ventilator care program intervention on survival of infants with ventilator-dependent bronchopulmonary dysplasia. Am J Perinatol. 34:155–163. 2017.PubMed/NCBI

2 

Nair V, Loganathan P and Soraisham AS: Azithromycin andother macrolides for prevention of bronchopulmonarydysplasia: A systematic review and meta-analysis. Neonatology. 106:337–347. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gadhia MM, Cutter GR, Abman SH and Kinsella JP: Effects of early inhaled nitric oxide therapy and vitamin A supplementation on the risk for bronchopulmonary dysplasia in premature newborns with respiratory failure. J Pediatr. 164:744–748. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Hu Q, Liu X and Zhou G: Effects of ligustrazine on hypoxia-inducible factor pathway expression in neonatal rats with BPD. J Pediatr Pharm. 20:1–5. 2014.

5 

Golovnin AK, Kostyuchenko MV, Georgiev PG and Melnikova LS: Mod(mdg4)-58.8, isoform of mod(mdg4) loci, directly interacts with MTACP1A and MTACP1B proteins of Drosophila melanogaster. Dokl Biochem Biophys. 466:5–8. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Vom Hove M, Prenzel F, Uhlig HH and Robel-Tillig E: Pulmonary outcome in former preterm, very low birth weight children with bronchopulmonary dysplasia: A case-control follow-up at school age. J Pediatr. 164:40–45.e4. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Balany J and Bhandari V: Understanding the impact of infection, inflammation, and their persistence in the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne). 2:902015.PubMed/NCBI

8 

Del Re DP, Miyamoto S and Brown JH: RhoA/Rho kinase upregulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 282:8069–8078. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Monteiro CB, Midão L, Rebelo S, Reguenga C, Lima D and Monteiro FA: Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons. Eur J Neurosci. 43:1449–1459. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Wang L, Feng Z and Lv H: Expressions of vascular endothelial growth factor and angiopoietin-1 in neonatal rats with hypoxia-induced BPD and effects on lung development. J Pract Med. 20:525–528. 2014.

11 

Tang H: ‘Vascular hypothesi’ of BPD and progress of Angiogenesis-promoting Treatment. J Clin Pediatr. 34:5532016.

12 

Liu Z, Lam N and Thiele CJ: Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription. Oncotarget. 6:27628–27640. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Li Q, Ma X and Zhang X: Pulmonary microvascular development and CD34 expression in rats with oxygen-induced BPD. J PLA Med. 26:25–28. 2014.

14 

Sauzeau V, Rolli-Derkinderen M, Lehoux S, Loirand G and Pacaud P: Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery. Circ Res. 93:630–637. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Pierro M, Ionescu L, Montemurro T, Vadivel A, Weissmann G, Oudit G, Emery D, Bodiga S, Eaton F, Péault B, et al: Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax. 68:475–484. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Julian L and Olson MF: Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions. Small GTPases. 5:e298462014. View Article : Google Scholar : PubMed/NCBI

17 

Stiles JM, Kurisetty V, Mitchell DC and Bryan BA: Rho kinase proteins regulate global miRNA expression in endothelial cells. Cancer Genomics Proteomics. 10:251–263. 2013.PubMed/NCBI

18 

Kaya G, Sivasli E, Oztuzcu S, Melekoglu NA, Ozkara E, Sarikabadayi U and Demiryürek AT: Association of Rho-kinase gene polymorphisms with respiratory distress syndrome in preterm neonates. Pediatr Neonatol. 58:36–42. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Tong R, Li X, Liang L and Huang H: Effects of CASZI on bronchopulmonary development of neonatal rats. Exp Ther Med 14: 6243-6246, 2017.
APA
Xu, L., Tong, R., Li, X., Liang, L., & Huang, H. (2017). Effects of CASZI on bronchopulmonary development of neonatal rats. Experimental and Therapeutic Medicine, 14, 6243-6246. https://doi.org/10.3892/etm.2017.5346
MLA
Xu, L., Tong, R., Li, X., Liang, L., Huang, H."Effects of CASZI on bronchopulmonary development of neonatal rats". Experimental and Therapeutic Medicine 14.6 (2017): 6243-6246.
Chicago
Xu, L., Tong, R., Li, X., Liang, L., Huang, H."Effects of CASZI on bronchopulmonary development of neonatal rats". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6243-6246. https://doi.org/10.3892/etm.2017.5346
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Tong R, Li X, Liang L and Huang H: Effects of CASZI on bronchopulmonary development of neonatal rats. Exp Ther Med 14: 6243-6246, 2017.
APA
Xu, L., Tong, R., Li, X., Liang, L., & Huang, H. (2017). Effects of CASZI on bronchopulmonary development of neonatal rats. Experimental and Therapeutic Medicine, 14, 6243-6246. https://doi.org/10.3892/etm.2017.5346
MLA
Xu, L., Tong, R., Li, X., Liang, L., Huang, H."Effects of CASZI on bronchopulmonary development of neonatal rats". Experimental and Therapeutic Medicine 14.6 (2017): 6243-6246.
Chicago
Xu, L., Tong, R., Li, X., Liang, L., Huang, H."Effects of CASZI on bronchopulmonary development of neonatal rats". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6243-6246. https://doi.org/10.3892/etm.2017.5346
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