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Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite

  • Authors:
    • Yanyan Lu
    • Chunyan Hao
    • Wubin He
    • Can Tang
    • Zhenya Shao
  • View Affiliations / Copyright

    Affiliations: College of Nursing, Jinzhou Medical University, Jinzhou, Liaoning 321001, P.R. China, Biological Treatment of Experimental Center, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 321001, P.R. China, Spinal Ward of Bone Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 321001, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 276-282
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/etm.2017.5347
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Abstract

Various types of complications arising from intravenous indwelling needles have become a challenge in clinical care. It is urgent to seek a simple and cost-effective method for prevention and treatment of phlebitis. We investigated the roles of mirabilite in preventing and treating phlebitis caused by intravenous indwelling needles and provide guidance for prevention and treatment of mechanical phlebitis caused by intravenous indwelling needles. A total of 57 healthy congeneric big-eared New Zealand rabbits were randomly divided into 3 groups: blank control, indwelling needle, and group with external application of mirabilite. The ear vein of each rabbit was punctured with an intravenous indwelling needle. The ear vein specimens were taken at 3, 5, and 7 days after indwelling. The hematoxylin and eosin stained pathological tissue sections of the ear veins of the rabbits in each group were observed. The expression levels of IL-1 and IL-6, and tumour necrosis factor-α (TNF-α) in the vascular tissue of the ear veins of the rabbits in each group were detected with the immunofluorescence method. In the blank control group, there was no inflammatory cellular infiltration and no proliferation of fibrous tissue around the vascular wall. With the increase of the indwelling time, proliferation of fibrous tissue in vascular wall, increased inflammatory cellular infiltration and organized thrombus in the vascular tissue occurred in the ear veins of the rabbits in the indwelling needle group and group with external application of mirabilite. Compared with the indwelling needle group, the group with external application of mirabilite had significantly decreased fibrous tissue in the vascular wall and significantly decreased inflammatory cellular infiltration. At the same point in indwelling time, the expression levels of IL-1, IL-6, and TNF-α in the indwelling needle and group with external application of mirabilite were significantly higher than that in the blank control group (P<0.05). The expression levels of IL-1, IL-6, and TNF-α in the group with external application of mirabilite were lower than that in the indwelling needle group (P<0.05).The expression levels of IL-1, IL-6, and TNF-α are positively correlated with the indwelling time within the same group at different points in time. In conclusion, external application of mirabilite can significantly decrease infiltration of venous inflammatory cells of the rabbit ear margin, proliferation of fibrous tissue and thrombosis in the vascular wall, significant decrease the expression levels of IL-1, IL-6, and TNF-α in the mechanical phlebitis caused by intravenous indwelling needles, and decrease the inflammatory responses of the ear veins of rabbits.
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1 

Kovalenko OM, Mal'tsev DV, Kazmirchuk VIe and Kovalenko AO: Studying of cytokine dynamics in injured persons with severe burns for estimation of severity and prognosis. Klin Khir. 2:49–53. 2014.(In Ukrainian).

2 

Ray-Barruel G, Polit DF, Murfield JE and Rickard CM: Infusion phlebitis assessment measures: A systematic review. J Eval Clin Pract. 20:191–202. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Saunders H: Translating knowledge into best practice care bundles: A pragmatic strategy for EBP implementation via moving postprocedural pain management nursing guidelines into clinical practice. J Clin Nurs. 24:2035–2051. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Powell J, Tarnow KG and Perucca R: The relationship between peripheral intravenous catheter indwell time and the incidence of phlebitis. J Infus Nurs. 31:39–45. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Grange-Prunier A, Couilliet D, Grange F and Guillaume JC: Allergic contact dermatitis to the Comfeel hydrocolloid dressing. Ann Dermatol Venereol. 129:725–727. 2002.(In French). PubMed/NCBI

6 

Kourbeti IS, Vakis AF, Ziakas P, Karabetsos D, Potolidis E, Christou S and Samonis G: Infections in patients undergoing craniotomy: Risk factors associated with post-craniotomy meningitis. J Neurosurg. 122:1113–1119. 2015. View Article : Google Scholar : PubMed/NCBI

7 

China Pharmacopoeia Committee: Pharmacopoeia of the People's Republic of China. China Medical Science Press; Beijing: pp. 118–119. 2010

8 

Wang Y, Zhang X and Li C: Applying hot compresses with Rhubarb and mirabilite to reduce pancreatic leakage occurrence in the treatment of severe acute pancreatitis. Iran JPublic Health. 46:136–138. 2017.

9 

Milutinović D, Simin D and Zec D: Risk factor for phlebitis: A questionnaire study of nurses' perception. Rev Lat Am Enfermagem. 23:677–684. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Abolfotouh MA, Salam M, Bani-Mustafa A, White D and Balkhy HH: Prospective study of incidence and predictors of peripheral intravenous catheter-induced complications. Ther Clin Risk Manag. 10:993–1001. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Hegerova LT, Leal AD, Grendahl DC, Seisler DK, Sorgatz KM, Anderson KJ, Hilger CR and Loprinzi CL: An analysis of fosaprepitant-induced venous toxicity in patients receiving highly emetogenic chemotherapy. Support Care Cancer. 23:55–59. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ and Warren DK: Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: Update by the Infectious Diseases Society of America. Clin Infect Dis. 49:1–45. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Ward-Kavanagh LK, Lin WW, Šedý JR and Ware CF: The TNF receptor superfamily in co-stimulating and co-inhibitory responses. Immunity. 44:1005–1019. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Ng PC, Li K, Leung TF, Wong RP, Li G, Chui KM, Wong E, Cheng FW and Fok TF: Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants. Clin Chem. 52:1181–1189. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Li WJ, Liu Y, Wang JJ, Zhang YL, Lai S, Xia YL, Wang HX and Li HH: ‘Angiotensin II memory’ contributes to the development of hypertension and vascular injury via activation of NADPH oxidase. Life Sci. 149:18–24. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Rickard CM, McCann D, Munnings J and McGrail MR: Routine resite of peripheral intravenous devices every 3 days did not reduce complications compared with clinically indicated resite: A randomised controlled trial. BMC Med. 8:532010. View Article : Google Scholar : PubMed/NCBI

17 

Zingg W and Pittet D: Peripheral venous catheters: An under-evaluated problem. Int J Antimicrob Agents. 34:38–42. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Karamanoglu A, Yumuk PF, Gumus M, Ekenel M, Aliustaoglu M, Selimen D, Sengoz M and Turhal NS: Port needles: Do they need to be removed as frequently in infusional chemotherapy? J Infus Nurs. 26:239–242. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Falkowski A: Improving the PICC insertion process. Nursing. 36:26–27. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Pandey D, Mehta S, Grover A and Goel N: Indwelling catheterization in Caesarean section: Time to retire it! J Clin Diagn Res. 9:01–04. 2015.

21 

Mo XR, Luo XJ, Li CP, Pan XF and Zhou LL: Effect ofmannitol injection by intravenous catheter on ear vein endothelial cell apoptosis and venous thrombus in rabbits. Eur Rev Med Pharmacol Sci. 19:491–497. 2015.PubMed/NCBI

22 

Watanabe D, Fukunaga M and Yamamoto H: Verification of the injection pressure reduction effect using the novel indwelling needle for contrast-enhanced CT. Nihon Hoshasen Gijutsu Gakkai Zasshi. 73:267–272. 2017. View Article : Google Scholar : PubMed/NCBI

23 

dos Reis PE, Silveira RC, Vasques CI and de Carvalho EC: Pharmacological interventionsto treat phlebitis: Systematic review. J Infus Nurs. 32:74–79. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Duan F, Yu Y, Guan R, Xu Z, Liang H and Hong L: Vitamin K2 induces mitochondria related apoptosis in human bladder cancer cells via ROS and JNK/p38 MAPK signal pathways. PLoS One. 11:e01618862016. View Article : Google Scholar : PubMed/NCBI

25 

Park KH and Park WJ: Endothelial dysfunction: Clinical implications in cardiovascular disease and therapeutic approaches. J Korean Med Sci. 30:1213–1225. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Thao NP, Luyen BT, Koo JE, Kim S, Koh YS, Thanh NV, Cuong NX, Kiem PV, Minh CV and Kim YH: In vitro anti-inflammatory components isolated from the carnivorous plant Nepenthes mirabilis ELour. F Rafarin. Pharm Biol. 54:588–594. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Hao C, He W, Tang C and Shao Z: Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite. Exp Ther Med 15: 276-282, 2018.
APA
Lu, Y., Hao, C., He, W., Tang, C., & Shao, Z. (2018). Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite. Experimental and Therapeutic Medicine, 15, 276-282. https://doi.org/10.3892/etm.2017.5347
MLA
Lu, Y., Hao, C., He, W., Tang, C., Shao, Z."Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite". Experimental and Therapeutic Medicine 15.1 (2018): 276-282.
Chicago
Lu, Y., Hao, C., He, W., Tang, C., Shao, Z."Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite". Experimental and Therapeutic Medicine 15, no. 1 (2018): 276-282. https://doi.org/10.3892/etm.2017.5347
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Hao C, He W, Tang C and Shao Z: Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite. Exp Ther Med 15: 276-282, 2018.
APA
Lu, Y., Hao, C., He, W., Tang, C., & Shao, Z. (2018). Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite. Experimental and Therapeutic Medicine, 15, 276-282. https://doi.org/10.3892/etm.2017.5347
MLA
Lu, Y., Hao, C., He, W., Tang, C., Shao, Z."Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite". Experimental and Therapeutic Medicine 15.1 (2018): 276-282.
Chicago
Lu, Y., Hao, C., He, W., Tang, C., Shao, Z."Experimental research on preventing mechanical phlebitis arising from indwelling needles in intravenous therapy by external application of mirabilite". Experimental and Therapeutic Medicine 15, no. 1 (2018): 276-282. https://doi.org/10.3892/etm.2017.5347
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