Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Histological study of postnatal development of mouse tongues

  • Authors:
    • Yifeng Jiang
    • Zhen Du
    • Long Chen
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Shandong Medical College, Linyi, Shangdong 276002, P.R. China, Department of Stomatology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China
  • Pages: 383-386
    |
    Published online on: October 23, 2017
       https://doi.org/10.3892/etm.2017.5350
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Numerous factors, including trauma, tumors and myophagism, may lead to tongue defects, which are mostly repaired via muscular flaps. However, these methods cannot restore the muscular function and gustation function of the tongue. Intensive research on tongue development may offer useful clues for tongue regeneration based on tissue engineering or stem cell therapy. In the present study, staining results revealed that tongue muscle fibers became larger, mature and stronger, and the foliate and fungiform papillae also became mature from newborn to adult C57BL/6J genetic background mice. Immunofluorescence staining and polymerase chain reaction results revealed that C‑kit was dynamically expressed in muscle cells, as well as in foliate and fungiform papilla cells from newborn to adult stages. The expression level decreased from P1 to P15 and increased at P90. The immunofluorescence staining results revealed that Ki‑67 was expressed in muscle cells and papilla cells from newborn to adult stages, and high expression was observed at P6 and P15. In addition, the immunofluorescence staining results also demonstrated that msh homeobox 2 (Msx2) was dynamically expressed in postnatal tongue muscle cells; however, almost no expression was detected in papilla cells. There was relative high expression level of Msx2 at P1 and P6 stages, but this gradually decreased from P15, and it was expressed primarily in the muscle cells located in the marginal zone of the tongue at P90. These findings suggest that the amount of c‑kit‑expressing precursor cells in tongue muscle and papilla cells increases to promote tongue development at the early postnatal stage and to maintain homeostasis and functional adaptation of the tongue in the adult stage. Furthermore, Msx2 may serve an important role in postnatal tongue muscle development. The present study also suggests that C‑kit and Msx2 may be used as cell markers for postnatal tongue regeneration and self‑repair, and may provide an approach for developing treatment methods for tongue diseases with a postnatal onset.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Cong W, Liu B, Liu S, Sun M, Liu H, Yang Y, Wang R and Xiao J: Implications of the Wnt5a/CaMKII pathway in retinoic acid-induced myogenic tongue abnormalities of developing mice. Sci Rep. 4:60822014. View Article : Google Scholar : PubMed/NCBI

2 

Iwata J, Suzuki A, Pelikan RC, Ho TV and Chai Y: Noncanonical transforming growth factor β (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 288:29760–29770. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Shuler CF and Dalrymple KR: Molecular regulation of tongue and craniofacial muscle differentiation. Crit Rev Oral Biol Med. 12:3–17. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Maciejewski A, Szymczyk C and Wierzgoń J: Triple skin island fibula free flap: A good choice for combined mandible and tongue defect reconstruction. J Reconstr Microsurg. 24:461–468. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Wang X, Qi S, Wang J, Xia D, Qin L, Zheng Z, Wang L, Zhang C, Jin L, Ding G, et al: Spatial and temporal expression of c-Kit in the development of the murine submandibular gland. J Mol Histol. 45:381–389. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Miller IJ Jr and Smith DV: Proliferation of taste buds in the foliate and vallate papillae of postnatal hamsters. Growth Dev Aging. 52:123–131. 1988.PubMed/NCBI

8 

Liu HX, Ermilov A, Grachtchouk M, Li L, Gumucio DL, Dlugosz AA and Mistretta CM: Multiple shh signaling centers participate in fungiform papilla and taste bud formation and maintenance. Dev Biol. 382:82–97. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Song XM, Ye JH, Yuan Y, Zhang SY, Jiang HB and Wu YN: Radial forearm free flap for reconstruction of a large defect after radical ablation of carcinoma of the tongue and floor of the mouth: Some new modifications. ORL J Otorhinolaryngol Relat Spec. 72:106–112. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Hindi SM and Kumar A: TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis. J Clin Invest. 126:151–168. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA and Morgan JE: Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. Cell. 122:289–301. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Wagers AJ and Conboy IM: Cellular and molecular signatures of muscle regeneration: Current concepts and controversies in adult myogenesis. Cell. 122:659–667. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Noda S, Horiguchi K, Ichikawa H and Miyoshi H: Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells. 26:646–655. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Sandstedt J, Jonsson M, Dellgren G, Lindahl A, Jeppsson A and Asp J: Human C-kit+CD45- cardiac stem cells are heterogeneous and display both cardiac and endothelial commitment by single-cell qPCR analysis. Biochem Biophys Res Commun. 443:234–238. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zhang YK, Han XY and Che ZY: Effects of buyang huanwu tang combined with bone marrow mesenchymal stem cell transplantation on the expression of VEGF and Ki-67 in the brain tissue of the cerebral ischemia-reperfusion model rat. J Tradit Chin Med. 30:278–282. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Yamane A, Mayo M, Shuler C, Crowe D, Ohnuki Y, Dalrymple K and Saeki Y: Expression of myogenic regulatory factors during the development of mouse tongue striated muscle. Arch Oral Biol. 45:71–78. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Kawabe Y, Wang YX, McKinnell IW, Bedford MT and Rudnicki MA: Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell. 11:333–345. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Kirkpatrick LJ, Allouh MZ, Nightingale CN, Devon HG, Yablonka-Reuveni Z and Rosser BW: Pax7 shows higher satellite cell frequencies and concentrations within intrafusal fibers of muscle spindles. J Histochem Cytochem. 56:831–840. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Lee H, Habas R and Abate-Shen C: MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science. 304:1675–1678. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Kodaka Y, Tanaka K, Kitajima K, Tanegashima K, Matsuda R and Hara T: LIM homeobox transcription factor Lhx2 inhibits skeletal muscle differentiation in part via transcriptional activation of Msx1 and Msx2. Exp Cell Res. 331:309–319. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Du Z and Chen L: Histological study of postnatal development of mouse tongues. Exp Ther Med 15: 383-386, 2018.
APA
Jiang, Y., Du, Z., & Chen, L. (2018). Histological study of postnatal development of mouse tongues. Experimental and Therapeutic Medicine, 15, 383-386. https://doi.org/10.3892/etm.2017.5350
MLA
Jiang, Y., Du, Z., Chen, L."Histological study of postnatal development of mouse tongues". Experimental and Therapeutic Medicine 15.1 (2018): 383-386.
Chicago
Jiang, Y., Du, Z., Chen, L."Histological study of postnatal development of mouse tongues". Experimental and Therapeutic Medicine 15, no. 1 (2018): 383-386. https://doi.org/10.3892/etm.2017.5350
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Du Z and Chen L: Histological study of postnatal development of mouse tongues. Exp Ther Med 15: 383-386, 2018.
APA
Jiang, Y., Du, Z., & Chen, L. (2018). Histological study of postnatal development of mouse tongues. Experimental and Therapeutic Medicine, 15, 383-386. https://doi.org/10.3892/etm.2017.5350
MLA
Jiang, Y., Du, Z., Chen, L."Histological study of postnatal development of mouse tongues". Experimental and Therapeutic Medicine 15.1 (2018): 383-386.
Chicago
Jiang, Y., Du, Z., Chen, L."Histological study of postnatal development of mouse tongues". Experimental and Therapeutic Medicine 15, no. 1 (2018): 383-386. https://doi.org/10.3892/etm.2017.5350
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team