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Article

Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model

  • Authors:
    • Lin Lv
    • Yucai Yao
    • Gang Zhao
    • Guiyue Zhu
  • View Affiliations / Copyright

    Affiliations: The First Clinical Institute, Jining Medical University, Jining, Shandong 272067, P.R. China, Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 506-512
    |
    Published online on: October 24, 2017
       https://doi.org/10.3892/etm.2017.5365
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Abstract

Rutin has a variety of pharmacological actions, including radical reactivity, and protective activity against lipid peroxidation, viruses and acute pancreatitis; thus, it may be used as a treatment for many diseases. The present study aimed to investigate whether rutin inhibits coronary heart disease through extracellular signal‑regulated kinase (ERK) 1/2 and Akt signaling in a porcine model. Male Chinese miniature pigs were randomly divided into four groups: A sham group, a coronary heart disease (CHD) model group, a group receiving 15 mg/kg rutin for 8 weeks following CHD modeling and a group receiving 45 mg/kg rutin for 8 weeks following CHD modeling. The results suggested that treatment with rutin suppressed the reduction in left ventricular ejection fraction and increase in systolic internal diameter that occurred in CHD model pigs. Rutin administration reduced the infarct size of the myocardium, attenuated LVEF, increased LVID and inhibited urine protein concentration, BUN and Scr expression levels in CHD model pigs. Results from western blot analysis demonstrated that in CHD pigs treated with 45 mg/kg rutin, the CHD‑associated increases in transforming growth factor β1 and SMAD2 expression and reductions in phosphorylated (p)‑ERK1/2 and p‑Akt expression were attenuated. The present study suggests that rutin inhibits coronary heart disease through ERK1/2 and Akt signaling pathways in a porcine model.
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Copy and paste a formatted citation
Spandidos Publications style
Lv L, Yao Y, Zhao G and Zhu G: Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model. Exp Ther Med 15: 506-512, 2018.
APA
Lv, L., Yao, Y., Zhao, G., & Zhu, G. (2018). Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model. Experimental and Therapeutic Medicine, 15, 506-512. https://doi.org/10.3892/etm.2017.5365
MLA
Lv, L., Yao, Y., Zhao, G., Zhu, G."Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model". Experimental and Therapeutic Medicine 15.1 (2018): 506-512.
Chicago
Lv, L., Yao, Y., Zhao, G., Zhu, G."Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model". Experimental and Therapeutic Medicine 15, no. 1 (2018): 506-512. https://doi.org/10.3892/etm.2017.5365
Copy and paste a formatted citation
x
Spandidos Publications style
Lv L, Yao Y, Zhao G and Zhu G: Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model. Exp Ther Med 15: 506-512, 2018.
APA
Lv, L., Yao, Y., Zhao, G., & Zhu, G. (2018). Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model. Experimental and Therapeutic Medicine, 15, 506-512. https://doi.org/10.3892/etm.2017.5365
MLA
Lv, L., Yao, Y., Zhao, G., Zhu, G."Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model". Experimental and Therapeutic Medicine 15.1 (2018): 506-512.
Chicago
Lv, L., Yao, Y., Zhao, G., Zhu, G."Rutin inhibits coronary heart disease through ERK1/2 and Akt signaling in a porcine model". Experimental and Therapeutic Medicine 15, no. 1 (2018): 506-512. https://doi.org/10.3892/etm.2017.5365
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