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Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction

  • Authors:
    • Lianfeng Wang
    • Tingting Cao
    • Haiting Chen
  • View Affiliations / Copyright

    Affiliations: Section One, Department of Ophthalmology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 300-304
    |
    Published online on: October 27, 2017
       https://doi.org/10.3892/etm.2017.5386
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Abstract

The treatment of glaucomatous optic nervedamage using ginsenoside Rg1 mediated by ultrasound targeted microbubbles destruction was evaluated. Thirty healthy New Zealand white rabbits were subjected to injection of 0.3% carbomer solution to establish glaucomatous optic nerve damage model. Rabbits were divided into 5 groups: control group, model group, model group + intravitreal injection of nerve growth factor (NGF) group, model group + intravitreal injection of ginsenoside Rg1 group (Rg1 group), model group + intravitreal injection of ginsenoside Rg1 + ultrasound microbubble group (ultrasound group), model group + ultrasound targeted microbubble destruction (ultrasound group). Intraocular pressures were compared at 1, 2 and 4 weeks after model establishment. Rabbits were sacrificed 4 weeks after model establishment to collect retinal tissue for H&E staining. Histological changes were observed and the retinal thickness was measured. Contents of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were measured by ELISA. Intraocular pressure was significantly higher in model group than in control group at 1 week (P<0.05). Intraocular pressure was significantly lower in the ultrasound group than in NGF group and Rg1 group at all time-points (P<0.05). The number of ganglion cells in model group was decreased significantly. Number of nuclear layer cells was significantly reduced. Thickest retina was found in control group and model group was the thinnest (P<0.05). Contents of MDA and NO in model group were significantly higher than those in NCF group and Rg1 group. SOD content in control group was higher than that in ultrasound group and model group (P<0.05). In conclusion, treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction can reduce the level of oxidative stress, relieve intraocular pressure and reduce ganglion cell damage.
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View References

1 

Quigley HA: Understanding Glaucomatous Optic Neuropathy: The synergy between clinical observation and investigation. Annu Rev Vis Sci. 2:235–254. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Chen X and Zhao Y: Diagnostic performance of isolated-check visual evoked potential versus retinal ganglion cell-inner plexiform layer analysis in early primary open-angle glaucoma. BMC Ophthalmol. 17:772017. View Article : Google Scholar : PubMed/NCBI

3 

Oddone F, Roberti G, Micera A, Busanello A, Bonini S, Quaranta L, Agnifili L and Manni G: Exploring serum levels of brain derived neurotrophic factor and nerve growth factor across glaucoma stages. PLoS One. 12:e01685652017. View Article : Google Scholar : PubMed/NCBI

4 

Mesentier-Louro LA, De Nicolò S, Rosso P, De Vitis LA, Castoldi V, Leocani L, Mendez-Otero R, Santiago MF, Tirassa P, Rama P, et al: Time-dependent nerve growth factor signaling changes in the rat retina during optic nerve crush-induced degeneration of retinal ganglion cells. Int J Mol Sci. 18:E982017. View Article : Google Scholar : PubMed/NCBI

5 

Hussein F, Antonescu C and Karshafian R: Ultrasound and microbubble induced release from intracellular compartments. BMC Biotechnol. 17:452017. View Article : Google Scholar : PubMed/NCBI

6 

Luo H, Huang WX, Yang C, Zhao JQ, Liu S, Xu YS and Liu CW: Therapeutic efficacy and mechanism of action of ginsenoside Rg1 in treating acute hepatic failure in mice. Zhonghua Gan Zang Bing Za Zhi. 25:217–222. 2017.(In Chinese). PubMed/NCBI

7 

Garcia TB, Hollborn M and Bringmann A: Expression and signaling of NGF in the healthy and injured retina. Cytokine Growth Factor Rev. 34:43–57. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kimura A, Namekata K, Guo X, Harada C and Harada T: Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration. Int J Mol Sci. 17:E15842016. View Article : Google Scholar : PubMed/NCBI

9 

Sun ZG, Chen LP, Wang FW, Xu CY and Geng M: Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells. Neural Regen Res. 11:1159–1164. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Huang L, Liu LF, Liu J, Dou L, Wang GY, Liu XQ and Yuan QL: Ginsenoside Rg1 protects against neurodegeneration by inducing neurite outgrowth in cultured hippocampal neurons. Neural Regen Res. 11:319–325. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Huo DS, Zhang M, Cai ZP, Dong CX, Wang H and Yang ZJ: The role of nerve growth factor in ginsenoside Rg1-induced regeneration of injured rat sciatic nerve. J Toxicol Environ Health A. 78:1328–1337. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Wang B, He L, Cui B and Lv H: Protection of ginsenoside Rg1 on central nerve cell damage and the influence on neuron apoptosis. Pak J Pharm Sci. 27 Suppl 6:2035–2040. 2014.PubMed/NCBI

13 

Li YB, Wang Y, Tang JP, Chen D and Wang SL: Neuroprotective effects of ginsenoside Rg1-induced neural stem cell transplantation on hypoxic-ischemic encephalopathy. Neural Regen Res. 10:753–759. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Guo X, Guo S, Pan L, Ruan L, Gu Y and Lai J: Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. Oncol Lett. 13:3669–3675. 2017.PubMed/NCBI

15 

Luo J, Zhou X, Diao L and Wang Z: Experimental research on wild-type p53 plasmid transfected into retinoblastoma cells and tissues using an ultrasound microbubble intensifier. J Int Med Res. 38:1005–1015. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Rokicki W, Zalejska-Fiolka J, Pojda-Wilczek D, Hampel A, Majewski W, Ogultekin S and Mrukwa-Kominek E: Differences in serum oxidative status between glaucomatous and nonglaucomatous cataract patients. BMC Ophthalmol. 17:132017. View Article : Google Scholar : PubMed/NCBI

17 

Panchal SS, Patidar RK, Jha AB, Allam AA, Ajarem J and Butani SB: Anti-inflammatory and antioxidative stress effects of oryzanol in glaucomatous rabbits. J Ophthalmol. 2017:14687162017. View Article : Google Scholar : PubMed/NCBI

18 

Mumcu UY, Kocer I, Ates O and Alp HH: Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma. Int J Ophthalmol. 9:1518–1520. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Cao T and Chen H: Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction. Exp Ther Med 15: 300-304, 2018.
APA
Wang, L., Cao, T., & Chen, H. (2018). Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction. Experimental and Therapeutic Medicine, 15, 300-304. https://doi.org/10.3892/etm.2017.5386
MLA
Wang, L., Cao, T., Chen, H."Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction". Experimental and Therapeutic Medicine 15.1 (2018): 300-304.
Chicago
Wang, L., Cao, T., Chen, H."Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction". Experimental and Therapeutic Medicine 15, no. 1 (2018): 300-304. https://doi.org/10.3892/etm.2017.5386
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Cao T and Chen H: Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction. Exp Ther Med 15: 300-304, 2018.
APA
Wang, L., Cao, T., & Chen, H. (2018). Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction. Experimental and Therapeutic Medicine, 15, 300-304. https://doi.org/10.3892/etm.2017.5386
MLA
Wang, L., Cao, T., Chen, H."Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction". Experimental and Therapeutic Medicine 15.1 (2018): 300-304.
Chicago
Wang, L., Cao, T., Chen, H."Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction". Experimental and Therapeutic Medicine 15, no. 1 (2018): 300-304. https://doi.org/10.3892/etm.2017.5386
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