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Article Open Access

The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats

  • Authors:
    • Jin‑Zhuo Ning
    • Wei Li
    • Fan Cheng
    • Ting Rao
    • Wei‑Min Yu
    • Yuan Ruan
    • Run Yuan
    • Xiao‑Bin Zhang
    • Yang Du
    • Cheng‑Cheng Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Anesthesia, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 433-439
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/etm.2017.5417
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Abstract

The aim of the present study was to evaluate whether morpholin‑4‑ium 4 methoxyphenyl (morpholino) phosphonodithioate (GYY4137) exhibits a protective effect on ipsilateral testicular injury in experimentally varicocele (VC)‑induced rats. A total of 48 rats were randomly divided into the following 6 groups (n=8 each): Group A (control group); group B (sham group); group C (VC group); group D (VC group administered 5 mg/kg/day GYY4137); group E (VC group administered 10 mg/kg/day GYY4137) and group F (VC group administered 20 mg/kg/day GYY4137). Indicators of oxidative stress, apoptosis and inflammation were measured to evaluate the effect of GYY4137 on ipsilateral testicular injury. Compared with groups A and B, rats in group C exhibited severe histological changes and an increase in oxidative stress, apoptosis and inflammation. By contrast, amelioration of testicular damage was evident in the group D, E and F that were treated with GYY4137. These results demonstrate that GYY4137 may be a promising therapy to treat VC as it alleviates oxidative stress, apoptosis and inflammation in experimentally VC‑induced rats.
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Copy and paste a formatted citation
Spandidos Publications style
Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhang XB, Du Y, Xiao CC, Xiao CC, et al: The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats. Exp Ther Med 15: 433-439, 2018.
APA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y. ... Xiao, C. (2018). The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats. Experimental and Therapeutic Medicine, 15, 433-439. https://doi.org/10.3892/etm.2017.5417
MLA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15.1 (2018): 433-439.
Chicago
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15, no. 1 (2018): 433-439. https://doi.org/10.3892/etm.2017.5417
Copy and paste a formatted citation
x
Spandidos Publications style
Ning JZ, Li W, Cheng F, Rao T, Yu WM, Ruan Y, Yuan R, Zhang XB, Du Y, Xiao CC, Xiao CC, et al: The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats. Exp Ther Med 15: 433-439, 2018.
APA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y. ... Xiao, C. (2018). The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats. Experimental and Therapeutic Medicine, 15, 433-439. https://doi.org/10.3892/etm.2017.5417
MLA
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15.1 (2018): 433-439.
Chicago
Ning, J., Li, W., Cheng, F., Rao, T., Yu, W., Ruan, Y., Yuan, R., Zhang, X., Du, Y., Xiao, C."The protective effects of GYY4137 on ipsilateral testicular injury in experimentally varicocele‑induced rats". Experimental and Therapeutic Medicine 15, no. 1 (2018): 433-439. https://doi.org/10.3892/etm.2017.5417
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