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Article

TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer

  • Authors:
    • Xing‑Guang Wang
    • Na‑Xin Yuan
    • Xin‑Peng Li
    • Fang‑Fang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Respiratory Medicine, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China, Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 365-370
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/etm.2017.5426
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Abstract

Cancer initiating cell (CIC) formation and epithelial‑mesenchymal transition (EMT) are pivotal events in lung cancer cell invasion and metastasis. They have been shown to occur in gefitinib resistance. Studying the molecular mechanisms of CICs, EMT and acquired gefitinib resistance will enhance the understanding of the pathogenesis and progression of the disease and offer novel targets for effective therapies. TWIK‑related acid‑sensitive K(+) (TASK‑1) is expressed in a subset of non‑small‑cell lung cancer (NSCLC) cell lines, where it promotes cell proliferation while inhibiting apoptosis. In the present study, TASK‑1 was demonstrated to induce gefitinib resistance in the A549 NSCLC cell line. Overexpression of TASK‑1 promoted the acquisition of CIC‑like traits by A549 cells. CD133, octamer‑binding transcription factor 4 (OCT‑4) and Nanog have been suggested to be markers of CICs in lung cancer. It was demonstrated that overexpression of TASK‑1 promoted CD133, OCT‑4 and Nanog protein expression in A549 cells. Increased formation of stem cell‑like populations results in EMT of cancer cells. The present study found that overexpression of TASK‑1 promoted EMT of A549 cells. Thus, downregulation of TASK‑1 may represent a novel strategy for EMT reversal, decreasing CIC‑like traits and increasing gefitinib sensitivity of NSCLCs.
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1 

Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, et al: Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 455:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Sanders HR and Albitar M: Somatic mutations of signaling genes in non-small-cell lung cancer. Cancer Genet Cytogenet. 203:7–15. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Costa DB, Kobayashi S, Tenen DG and Huberman MS: Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers. Lung Cancer. 58:95–103. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Miller VA, Riely GJ, Zakowski MF, Li AR, Patel JD, Heelan RT, Kris MG, Sandler AB, Carbone DP, Tsao A, et al: Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J Clin Oncol. 26:1472–1478. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Jackman DM, Miller VA, Cioffredi LA, Yeap BY, Jänne PA, Riely GJ, Ruiz MG, Giaccone G, Sequist LV and Johnson BE: Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials. Clin Cancer Res. 15:5267–5273. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rho JK, Choi YJ, Lee JK, Ryoo BY, Na II, Yang SH, Kim CH and Lee JC: Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line. Lung Cancer. 63:219–226. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Li D, Zhang L, Zhou J and Chen H: Cigarette smoke extract exposure induces EGFR-TKI resistance in EGFR-mutated NSCLC via mediating Src activation and EMT. Lung Cancer. 93:35–42. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Grünert S, Jechlinger M and Beug H: Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol. 4:657–665. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Kalluri R and Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 112:1776–1784. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol. 15:740–746. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Pine SR, Marshall B and Varticovski L: Lung cancer stem cells. Dis Markers. 24:257–266. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A, Conticello C, Ruco L, Peschle C and De Maria R: Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 15:504–514. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT and Jacks T: Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell. 121:823–835. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Jiang F, Qiu Q, Khanna A, Todd NW, Deepak J, Xing L, Wang H, Liu Z, Su Y, Stass SA and Katz RL: Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol Cancer Res. 7:330–338. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer. 5:275–284. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Huang CP, Tsai MF, Chang TH, Tang WC, Chen SY, Lai HH, Lin TY, Yang JC, Yang PC, Shih JY and Lin SB: ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Cancer Lett. 328:144–151. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Leithner K, Hirschmugl B, Li Y, Tang B, Papp R, Nagaraj C, Stacher E, Stiegler P, Lindenmann J, Olschewski A, et al: TASK-1 regulates apoptosis and proliferation in a subset of non-small cell lung cancers. PLoS One. 11:e01574532016. View Article : Google Scholar : PubMed/NCBI

19 

Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Hung SC, Chang YL, Tsai ML, Lee YY, et al: Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One. 3:e26372008. View Article : Google Scholar : PubMed/NCBI

20 

Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, Chang HT, Chen YS, Lin TW, Hsu HS and Wu CW: Coexpression of Oct4 and nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 70:10433–10444. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, Doiphode RY and Bapat SA: Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian Cancer cells. Stem Cells. 27:2059–2068. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S and Puisieux A: Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One. 3:e28882008. View Article : Google Scholar : PubMed/NCBI

24 

Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, Kalli KR, Haluska P, Ingle JN, Hartmann LC, Manjili MH, et al: Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 69:2887–2895. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Tiran V, Stanzer S, Heitzer E, Meilinger M, Rossmann C, Lax S, Tsybrovskyy O, Dandachi N and Balic M: Genetic profiling of putative breast cancer stem cells from malignant pleural effusions. PLoS One. 12:e01752232017. View Article : Google Scholar : PubMed/NCBI

26 

Demicheli R, Fornili M, Ambrogi F, Higgins K, Boyd JA, Biganzoli E and Kelsey CR: Recurrence dynamics for non-small-cell lung cancer: Effect of surgery on the development of metastases. J Thorac Oncol. 7:723–730. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Senthi S, Lagerwaard FJ, Haasbeek CJ, Slotman BJ and Senan S: Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: A retrospective analysis. Lancet Oncol. 13:802–809. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Sève P and Dumontet C: Chemoresistance in non-small cell lung cancer. Curr Med Chem Anticancer Agents. 5:73–88. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Lara PN Jr, Lau DH and Gandara DR: Non-small-cell lung cancer progression after first-line chemotherapy. Curr Treat Options Oncol. 3:53–58. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Sun S, Schiller JH and Gazdar AF: Lung cancer in never smokers-a different disease. Nat Rev Cancer. 7:778–790. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Brugger W and Thomas M: EGFR-TKI resistant non-small cell lung cancer (NSCLC): New developments and implications for future treatment. Lung Cancer. 77:2–8. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Nurwidya F, Takahashi F, Murakami A, Kobayashi I, Kato M, Shukuya T, Tajima K, Shimada N and Takahashi K: Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors. Respir Investig. 52:82–91. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wangari-Talbot J and Hopper-Borge E: Drug resistance mechanisms in non-small cell lung carcinoma. J Can Res Updates. 2:265–282. 2013.PubMed/NCBI

34 

Chong CR and Jänne PA: The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med. 19:1389–1400. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zhou BB, Zhang H, Damelin M, Geles KG, Grindley JC and Dirks PB: Tumour-initiating cells: Challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov. 8:806–823. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Frank NY, Schatton T and Frank MH: The therapeutic promise of the cancer stem cell concept. J Clin Invest. 120:41–50. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, Rich JN and Sullenger BA: Notch promotes radioresistance of glioma stem cells. Stem Cells. 28:17–28. 2010.PubMed/NCBI

38 

Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Xie M, Zhang L, He CS, Xu F, Liu JL, Hu ZH, Zhao LP and Tian Y: Activation of notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J Cell Biochem. 113:1501–1513. 2012.PubMed/NCBI

40 

Hirvonen R, Talvensaari-Mattila A, Pääkkö P and Turpeenniemi-Hujanen T: Matrix metalloproteinase-2 (MMP-2) in T(1–2)N0 breast carcinoma. Breast Cancer Res Treat. 77:85–91. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Kalhori V and Törnquist K: MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. Mol Cell Endocrinol. 404:113–122. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Liu B, Cui J, Sun J, Li J, Han X, Guo J, Yi M, Amizuka N, Xu X and Li M: Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells. Mol Med Rep. 14:1099–1106. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang XG, Yuan NX, Li XP and Chen FF: TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer. Exp Ther Med 15: 365-370, 2018.
APA
Wang, X., Yuan, N., Li, X., & Chen, F. (2018). TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer. Experimental and Therapeutic Medicine, 15, 365-370. https://doi.org/10.3892/etm.2017.5426
MLA
Wang, X., Yuan, N., Li, X., Chen, F."TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer". Experimental and Therapeutic Medicine 15.1 (2018): 365-370.
Chicago
Wang, X., Yuan, N., Li, X., Chen, F."TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer". Experimental and Therapeutic Medicine 15, no. 1 (2018): 365-370. https://doi.org/10.3892/etm.2017.5426
Copy and paste a formatted citation
x
Spandidos Publications style
Wang XG, Yuan NX, Li XP and Chen FF: TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer. Exp Ther Med 15: 365-370, 2018.
APA
Wang, X., Yuan, N., Li, X., & Chen, F. (2018). TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer. Experimental and Therapeutic Medicine, 15, 365-370. https://doi.org/10.3892/etm.2017.5426
MLA
Wang, X., Yuan, N., Li, X., Chen, F."TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer". Experimental and Therapeutic Medicine 15.1 (2018): 365-370.
Chicago
Wang, X., Yuan, N., Li, X., Chen, F."TASK‑1 induces gefitinib resistance by promoting cancer initiating cell formation and epithelial‑mesenchymal transition in lung cancer". Experimental and Therapeutic Medicine 15, no. 1 (2018): 365-370. https://doi.org/10.3892/etm.2017.5426
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