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Article

Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus

  • Authors:
    • Qi‑Feng Suo
    • Jun Sheng
    • Fu‑Yong Qiang
    • Zong‑Sheng Tang
    • Ying‑Ying Yang
  • View Affiliations / Copyright

    Affiliations: Department of Central Laboratory, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Rheumatism and Immunology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Physical Examination Center, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R. China
  • Pages: 345-350
    |
    Published online on: November 1, 2017
       https://doi.org/10.3892/etm.2017.5429
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Abstract

The present study aimed to assess the expression of growth arrest‑specific 5 (GAS5) and microRNA (miR)‑21 in systemic lupus erythematosus (SLE), and attempted to explore their association with clinical features. CD4+ T cells were isolated from peripheral blood of healthy donors and SLE patients by magnetic‑activated cell sorting. GAS5 and miR‑21 expression levels in cluster of differentiation (CD)4+ T cells were measured by reverse‑transcription quantitative polymerase chain reaction. The results revealed that GAS5 and miR‑21 levels were significantly elevated in CD4+ T cells of patients with SLE compared with those in control subjects (P<0.05). Regarding clinical features, SLE patients with ulceration had higher GAS5 expression levels in CD4+ T cells than those without ulceration (P<0.05), and the expression of miR‑21 was significantly higher in CD4+ T cells of SLE patients with low levels of complement component 3 (C3) than in those with normal levels of complement C3 (P<0.05). In conclusion, GAS5 and miR‑21 in CD4+ T cells may serve as potential biomarkers for the diagnosis and monitoring of the progression of SLE.
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Copy and paste a formatted citation
Spandidos Publications style
Suo QF, Sheng J, Qiang FY, Tang ZS and Yang YY: Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus. Exp Ther Med 15: 345-350, 2018.
APA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., & Yang, Y. (2018). Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus. Experimental and Therapeutic Medicine, 15, 345-350. https://doi.org/10.3892/etm.2017.5429
MLA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15.1 (2018): 345-350.
Chicago
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15, no. 1 (2018): 345-350. https://doi.org/10.3892/etm.2017.5429
Copy and paste a formatted citation
x
Spandidos Publications style
Suo QF, Sheng J, Qiang FY, Tang ZS and Yang YY: Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus. Exp Ther Med 15: 345-350, 2018.
APA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., & Yang, Y. (2018). Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus. Experimental and Therapeutic Medicine, 15, 345-350. https://doi.org/10.3892/etm.2017.5429
MLA
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15.1 (2018): 345-350.
Chicago
Suo, Q., Sheng, J., Qiang, F., Tang, Z., Yang, Y."Association of long non‑coding RNA GAS5 and miR‑21 levels in CD4+ T cells with clinical features of systemic lupus erythematosus". Experimental and Therapeutic Medicine 15, no. 1 (2018): 345-350. https://doi.org/10.3892/etm.2017.5429
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