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Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure

  • Authors:
    • Haiyang Liu
    • Suyan Li
    • Zhengpei Zhang
    • Jie Shen
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Xuzhou First People's Hospital of Xuzhou Medical University, Xuzhou Eye Research Institute, Xuzhou, Jiangsu 221002, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 890-896
    |
    Published online on: November 3, 2017
       https://doi.org/10.3892/etm.2017.5437
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Abstract

The study investigated predictive factors for best‑corrected visual acuity (BCVA) after ranibizumab treatment in patients with macular edema (ME) associated with retinal vein occlusion (RVO) with an original ranking for the impairment of macular microstructure. In this retrospective study, 31 eyes of 31 patients with RVO received 3 monthly consecutive ranibizumab injections and another 3 months of follow‑up. An original method was applied to rank the impairment of the external limiting membrane (ELM) and the ellipsoid zone (previously called the photoreceptor inner and outer segment junction, IS/OS) integrity on the baseline optical coherence tomography (OCT) images. Univariate and multivariate linear regression analyses were performed to assess the association between the baseline factors and post-treatment BCVA. ELM integrity and baseline BCVA were shown to be independent factors in the prediction of post-treatment BCVA. Comparison of post-treatment BCVA between original ELM ranks after adjusting for the baseline BCVA revealed the ELM integrity beneath the center of the fovea was important to post-treatment BCVA. ELM integrity in particular beneath the center of the fovea and baseline BCVA may be more useful than other factors in the prediction of visual function in patients with ME secondary to RVO after ranibizumab injections.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Li S, Zhang Z and Shen J: Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. Exp Ther Med 15: 890-896, 2018.
APA
Liu, H., Li, S., Zhang, Z., & Shen, J. (2018). Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. Experimental and Therapeutic Medicine, 15, 890-896. https://doi.org/10.3892/etm.2017.5437
MLA
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15.1 (2018): 890-896.
Chicago
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15, no. 1 (2018): 890-896. https://doi.org/10.3892/etm.2017.5437
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Li S, Zhang Z and Shen J: Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. Exp Ther Med 15: 890-896, 2018.
APA
Liu, H., Li, S., Zhang, Z., & Shen, J. (2018). Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. Experimental and Therapeutic Medicine, 15, 890-896. https://doi.org/10.3892/etm.2017.5437
MLA
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15.1 (2018): 890-896.
Chicago
Liu, H., Li, S., Zhang, Z., Shen, J."Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure". Experimental and Therapeutic Medicine 15, no. 1 (2018): 890-896. https://doi.org/10.3892/etm.2017.5437
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