|
1
|
Chavali V, Tyagi SC and Mishra PK:
Predictors and prevention of diabetic cardiomyopathy. Diabetes
Metab Syndr Obes. 6:151–160. 2013.PubMed/NCBI
|
|
2
|
Rubler S, Dlugash J, Yuceoglu YZ, Kumral
T, Branwood AW and Grishman A: New type of cardiomyopathy
associated with diabetic glomerulosclerosis. Am J Cardiol.
30:595–602. 1972. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hayat SA, Patel B, Khattar RS and Malik
RA: Diabetic cardiomyopathy: Mechanisms, diagnosis, and treatment.
Clin Sci (Lond). 107:539–557. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zhou X and Lu X: The role of oxidative
stress in high glucose-induced apoptosis in neonatal rat
cardiomyocytes. Exp Biol Med (Maywood). 238:898–902. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Huynh K, Bernardo BC, McMullen JR and
Ritchie RH: Diabetic cardiomyopathy: Mechanisms and new treatment
strategies targeting antioxidant signaling pathways. Pharmacol
Ther. 142:375–415. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Sherwood OD: Relaxin's physiological roles
and other diverse actions. Endocr Rev. 25:205–234. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bitto A, Irrera N, Minutoli L, Calò M, Lo
Cascio P, Caccia P, Pizzino G, Pallio G, Micali A, Vaccaro M, et
al: Relaxin improves multiple markers of wound healing and
ameliorates the disturbed healing pattern of genetically diabetic
mice. Clin Sci. 125:575–585. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Samuel CS, Unemori EN, Mookerjee I,
Bathgate RA, Layfield SL, Mak J, Tregear GW and Du XJ: Relaxin
modulates cardiac fibroblast proliferation, differentiation, and
collagen production and reverses cardiac fibrosis in vivo.
Endocrinology. 145:4125–4133. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Taylor MJ and Clark CL: Evidence for a
novel source of relaxin: Atrial cardiocytes. J Endocrinol.
143:R5–R8. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Formigli L, Francini F, Nistri S, Margheri
M, Luciani G, Naro F, Silvertown JD, Orlandini SZ, Meacci E and
Bani D: Skeletal myoblasts overexpressing relaxin improve
differentiation and communication of primary murine cardiomyocyte
cell cultures. J Mol Cell Cardiol. 47:335–345. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Boccalini G, Sassoli C, Formigli L, Bani D
and Nistri S: Relaxin protects cardiac muscle cells from
hypoxia/reoxygenation injury: Involvement of the Notch-1 pathway.
FASEB J. 29:239–249. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Tan YY, Wade JD, Tregear GW and Summers
RJ: Quantitative autoradiographic studies of relaxin binding in rat
atria, uterus and cerebral cortex: Characterization and effects of
oestrogen treatment. Br J Pharmacol. 127:91–98. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang P, Li HW, Wang YP, Chen H and Zhang
P: Effects of recombinant human relaxin upon proliferation of
cardiac fibroblast and synthesis of collagen under high glucose
condition. J Endocrinol Invest. 32:242–247. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zhang X, Ma X, Zhao M, Zhang B, Chi J, Liu
W, Chen W, Fu Y, Liu Y and Yin X: H2 and H3 relaxin inhibit high
glucose-induced apoptosis in neonatal rat ventricular myocytes.
Biochimie. 108:59–67. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Parikh A, Patel D, McTiernan CF, Xiang W,
Haney J, Yang L, Lin B, Kaplan AD, Bett GC, Rasmusson RL, et al:
Relaxin suppresses atrial fibrillation by reversing fibrosis and
myocyte hypertrophy and increasing conduction velocity and sodium
current in spontaneously hypertensive rat hearts. Circ Res.
113:313–321. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Moore XL, Tan SL, Lo CY, Fang L, Su YD,
Gao XM, Woodcock EA, Summers RJ, Tregear GW, Bathgate RA and Du XJ:
Relaxin antagonizes hypertrophy and apoptosis in neonatal rat
cardiomyocytes. Endocrinology. 148:1582–1589. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
High FA and Epstein JA: The multifaceted
role of Notch in cardiac development and disease. Nat Rev Genet.
9:49–61. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
18
|
Dabral S, Tian X, Kojonazarov B, Savai R,
Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, et
al: Notch1 signalling regulates endothelial proliferation and
apoptosis in pulmonary arterial hypertension. Eur Respir J.
48:1137–1149. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Nemir M, Metrich M, Plaisance I, Lepore M,
Cruchet S, Berthonneche C, Sarre A, Radtke F and Pedrazzini T: The
Notch pathway controls fibrotic and regenerative repair in the
adult heart. Eur Heart J. 35:2174–2185. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Urbanek K, Cabral-da-Silva MC, Ide-Iwata
N, Maestroni S, Delucchi F, Zheng H, Ferreira-Martins J, Ogórek B,
D'Amario D, Bauer M, et al: Inhibition of notch1-dependent
cardiomyogenesis leads to a dilated myopathy in the neonatal heart.
Circ Res. 107:429–441. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Sassoli C, Chellini F, Pini A, Tani A,
Nistri S, Nosi D, Zecchi-Orlandini S, Bani D and Formigli L:
Relaxin prevents cardiac fibroblast-myofibroblast transition via
notch-1-mediated inhibition of TGF-β/Smad3 signaling. PLoS One.
8:e638962013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zhou X, Chen X, Cai JJ, Chen LZ, Gong YS,
Wang LX, Gao Z, Zhang HQ, Huang WJ and Zhou H: Relaxin inhibits
cardiac fibrosis and endothelial-mesenchymal transition via the
Notch pathway. Drug Des Devel Ther. 9:4599–4611. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Bani D, Pini A and Yue SK: Relaxin,
insulin and diabetes: An intriguing connection. Curr Diabetes Rev.
8:329–335. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhang X, Zhu M, Zhao M, Chen W, Fu Y, Liu
Y, Liu W, Zhang B, Yin X and Bai B: The plasma levels of relaxin-2
and relaxin-3 in patients with diabetes. Clin Biochem.
46:1713–1716. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Whittaker PG, Edwards JR, Randolph C,
Büllesbach EE, Schwabe C and Steinetz BG: Abnormal relaxin
secretion during pregnancy in women with type 1 diabetes. Exp Biol
Med (Maywood). 228:33–40. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Gupta MK, Neelakantan TV, Sanghamitra M,
Tyagi RK, Dinda A, Maulik S, Mukhopadhyay CK and Goswami SK: An
assessment of the role of reactive oxygen species and redox
signaling in norepinephrine-induced apoptosis and hypertrophy of
H9c2 cardiac myoblasts. Antioxid Redox Signal. 8:1081–1093. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ng HH, Jelinic M, Parry LJ and Leo CH:
Increased superoxide production and altered nitric oxide-mediated
relaxation in the aorta of young but not old male relaxin-deficient
mice. Am J Physiol Heart Circ Physiol. 309:H285–H296. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Willcox JM and Summerlee AJ: Relaxin
protects astrocytes from hypoxia in vitro. PLoS One. 9:e908642014.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lakhani SA, Masud A, Kuida K, Porter GA
Jr, Booth CJ, Mehal WZ, Inayat I and Flavell RA: Caspases 3 and 7:
Key mediators of mitochondrial events of apoptosis. Science.
311:847–851. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Xu Q, Lekgabe ED, Gao XM, Ming Z, Tregear
GW, Dart AM, Bathgate RA, Samuel CS and Du XJ: Endogenous relaxin
does not affect chronic pressure overload-induced cardiac
hypertrophy and fibrosis. Endocrinology. 149:476–482. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Cai L, Li W, Wang G, Guo L, Jiang Y and
Kang YJ: Hyperglycemia-induced apoptosis in mouse myocardium:
mitochondrial cytochrome C-mediated caspase-3 activation pathway.
Diabetes. 51:1938–1948. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yang RH, Qi SH, Shu B, Ruan SB, Lin ZP,
Lin Y, Shen R, Zhang FG, Chen XD and Xie JL: Epidermal stem cells
(ESCs) accelerate diabetic wound healing via the Notch signalling
pathway. Biosci Rep. 36:pii: e003642016. View Article : Google Scholar
|
|
34
|
Yoon CH, Choi YE, Cha YR, Koh SJ, Choi JI,
Kim TW, Woo SJ, Park YB, Chae IH and Kim HS: Diabetes-induced
jagged1 overexpression in endothelial cells causes retinal
capillary regression in a murine model of diabetes mellitus:
Insights into diabetic retinopathy. Circulation. 134:233–247. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhang J, Li B, Zheng Z, Kang T, Zeng M,
Liu Y and Xia B: Protective effects of Notch1 signaling activation
against high glucose-induced myocardial cell injury: Analysis of
its mechanisms of action. Int J Mol Med. 36:897–903. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Basu M, Bosse K and Garg V: Notch1
Haploinsufficiency Increases Risk of Congenital Heart Defects in
the Setting of Maternal Diabetes by an Epigenetic Mechanism.
Circulation. 130:192852014.
|
|
37
|
Pei H, Yu Q, Xue Q, Guo Y, Sun L, Hong Z,
Han H, Gao E, Qu Y and Tao L: Notch1 cardioprotection in myocardial
ischemia/reperfusion involves reduction of oxidative/nitrative
stress. Basic Res Cardiol. 108:3732013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Zhou XL, Wan L, Xu QR, Zhao Y and Liu JC:
Notch signaling activation contributes to cardioprotection provided
by ischemic preconditioning and postconditioning. J Transl Med.
11:2512013. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Nemir M, Jordan N, Croquelois A,
Domenighetti A and Pedrazzini T: Notch signaling: A potential
regulator of cardiac response to hypertrophic stimuli. J Mol Cell
Cardiol. 42 Suppl:S134–S135. 2007. View Article : Google Scholar
|
