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Article

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Retraction in: /10.3892/etm.2022.11432
  • Authors:
    • Ying Ye
    • Juhua Zhuang
    • Guangdong Wang
    • Saifei He
    • Suiliang Zhang
    • Guoyu Wang
    • Jing Ni
    • Jiening Wang
    • Wei Xia
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China, Department of Research and Development, The Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China, Department of Oncology, The Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200137, P.R. China
  • Pages: 1150-1158
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/etm.2017.5467
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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common malignancy and second‑most frequent cause of cancer‑associated deaths worldwide. Previously, increasing studies report that microRNAs (miRNAs/miRs) are abnormally expressed in various types of human cancers and may participate in the tumourigenesis and tumour development of HCC. miRNA‑based targeted therapy is effective against different molecular targets and may increase the sensitisation of cancer cells to therapy by several folds. Therefore, further validation of potentially important miRNAs involved in HCC initiation and progression may provide valuable insights into the treatment of patients with HCC. miR‑495 is abnormally expressed in multiple types of human cancers. However, the expression level and roles of miR‑495 in HCC have yet to be completely elucidated. In the present study, miR‑495 expression was frequently downregulated in HCC tissues and cell lines, and miR‑495 expression levels were significantly correlated with tumour size, tumor‑node‑metastasis (TNM) stage and lymph node metastasis in patients with HCC. Functional assays revealed that miR‑495 overexpression inhibited cell proliferation and invasion in HCC. Insulin‑like growth factor receptor‑1 (IGF1R) was identified as a direct target gene of miR‑495 in HCC. IGF1R was upregulated in HCC tissues and negatively correlated with miR‑495 expression level. The upregulation of IGF1R rescued the miR‑495‑induced tumour‑suppressive roles in HCC cell proliferation and invasion, and the restored miR‑495 expression inactivated the protein kinase B and extracellular regulated protein kinase signalling pathways in HCC. These results provide novel insights into the molecular mechanism underlying HCC progression, and suggest that miR‑495 may be investigated as a novel therapeutic target for patients with this disease.
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View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Forner A, Llovet JM and Bruix J: Hepatocellular carcinoma. Lancet. 379:1245–1255. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Yu MC and Yuan JM: Environmental factors and risk for hepatocellular carcinoma. Gastroenterology. 127 5 Suppl 1:S72–S78. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Zeng Z: Human genes involved in hepatitis B virus infection. World J Gastroenterol. 20:7696–7706. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Dhanasekaran R, Limaye A and Cabrera R: Hepatocellular carcinoma: Current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepat Med. 4:19–37. 2012.PubMed/NCBI

7 

Aravalli RN, Steer CJ and Cressman EN: Molecular mechanisms of hepatocellular carcinoma. Hepatology. 48:2047–2063. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell. 11:441–450. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Gu S, Jin L, Zhang F, Sarnow P and Kay MA: Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs. Nat Struct Mol Biol. 16:144–150. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Yan JJ, Chang Y, Zhang YN, Lin JS, He XX and Huang HJ: miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma. Oncol Lett. 13:3118–3126. 2017.PubMed/NCBI

12 

Pengcheng S, Ziqi W, Luyao Y, Xiangwei Z, Liang L, Yuwei L, Lechen L and Wanhai X: MicroRNA-497 suppresses renal cell carcinoma by targeting VEGFR-2 in ACHN cells. Biosci Rep. 37:pii: BSR201702702017. View Article : Google Scholar

13 

Li F, Guo Y, Liu J and Zhang R: The significance of elevated plasma expression of microRNA 106b~25 clusters in gastric cancer. PLoS One. 12:e01784272017. View Article : Google Scholar : PubMed/NCBI

14 

Fateh A, Feizi MAH, Safaralizadeh R and Azarbarzin S: Importance of miR-299-5p in colorectal cancer. Ann Gastroenterol. 30:322–326. 2017.PubMed/NCBI

15 

Lujambio A and Lowe SW: The microcosmos of cancer. Nature. 482:347–355. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Ebert MS and Sharp PA: Roles for microRNAs in conferring robustness to biological processes. Cell. 149:515–524. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Iorio MV and Croce CM: microRNA involvement in human cancer. Carcinogenesis. 33:1126–1133. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Tan M, Mu X, Liu Z, Tao L, Wang J, Ge J and Qiu J: microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog. Biochem Biophys Res Commun. 483:867–873. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Jiang W, Zheng J, Yu T and Wang J: Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5. Oncol Rep. 38:1099–1107. 2017.PubMed/NCBI

20 

Liu P, Hu Y, Ma L, Du M, Xia L and Hu Z: miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1. Biomed Pharmacother. 75:51–57. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Xu YY, Tian J, Hao Q and Yin LR: MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer. Tumour Biol. 37:239–251. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, et al: MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci USA. 109:pp. 19397–19402. 2012; View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Lin SB, Zhou L, Liang ZY, Zhou WX and Jin Y: Expression of GRK2 and IGF1R in hepatocellular carcinoma: Clinicopathological and prognostic significance. J Clin Pathol. 70:754–759. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Yao WF, Liu JW, Sheng GL and Huang DS: Blockade of IGF-IR exerts anticancer effects in hepatocellular carcinoma. Mol Med Rep. 4:719–722. 2011.PubMed/NCBI

26 

Zhang W, Liu K, Liu S, Ji B, Wang Y and Liu Y: MicroRNA-133a functions as a tumor suppressor by targeting IGF-1R in hepatocellular carcinoma. Tumour Biol. 36:9779–9788. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Guo T, Feng Y, Liu Q, Yang X, Jiang T, Chen Y and Zhang Q: MicroRNA-320a suppresses in GBM patients and modulates glioma cell functions by targeting IGF-1R. Tumour Biol. 35:11269–11275. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Chen G, Fang T, Huang Z, Qi Y, Du S, Di T, Lei Z, Zhang X and Yan W: MicroRNA-133a inhibits osteosarcoma cells proliferation and invasion via targeting IGF-1R. Cell Physiol Biochem. 38:598–608. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Yuan J, Ji H, Xiao F, Lin Z, Zhao X, Wang Z, Zhao J and Lu J: MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1. Biochem Biophys Res Commun. 483:578–584. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Duan X, Bai J, Wei J, Li Z, Liu X and Xu G: MicroRNA-508-5p suppresses metastasis in human gastric cancer by targeting S-phase kinase-associated protein 2. Mol Med Rep. 16:2163–2171. 2017.PubMed/NCBI

31 

Ma F, Li W, Liu C, Li W, Yu H, Lei B, Ren Y, Li Z, Pang D and Qian C: MiR-23a promotes TGF-beta1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/beta-catenin signaling. Oncotarget. 8:69538–69550. 2017.PubMed/NCBI

32 

Han K, Li J, Zhao H, Liang P, Huang X, Zheng L, Li Y, Yang T and Wang L: Identification of the typical miRNAs and target genes in hepatocellular carcinoma. Mol Med Rep. 10:229–235. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Afonso MB, Rodrigues PM, Simão AL and Castro RE: Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma. J Clin Med. 5:pii: E302016. View Article : Google Scholar

34 

Gandhi NS, Tekade RK and Chougule MB: Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: Current progress and advances. J Control Release. 194:238–256. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Wang C, Yun Z, Zhao T, Liu X and Ma X: MiR-495 is a predictive biomarker that downregulates GFI1 expression in medulloblastoma. Cell Physiol Biochem. 36:1430–1439. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Formosa A, Markert EK, Lena AM, Italiano D, Finazzi-Agro' E, Levine AJ, Bernardini S, Garabadgiu AV, Melino G and Candi E: MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. Oncogene. 33:5173–5182. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Lv C, Bai Z, Liu Z, Luo P and Zhang J: MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1. Am J Transl Res. 7:1992–1999. 2015.PubMed/NCBI

38 

Chen Y, Luo D, Tian W, Li Z and Zhang X: Demethylation of miR-495 inhibits cell proliferation, migration and promotes apoptosis by targeting STAT-3 in breast cancer. Oncol Rep. 37:3581–3589. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Wang L, Liu JL, Yu L, Liu XX, Wu HM, Lei FY, Wu S and Wang X: Downregulated miR-495 [Corrected] inhibits the G1-S phase transition by targeting Bmi-1 in breast cancer. Medicine. 94:e7182015. View Article : Google Scholar : PubMed/NCBI

40 

Wei T, Zhu W, Fang S, Zeng X, Huang J, Yang J, Zhang J and Guo L: miR-495 promotes the chemoresistance of SCLC through the epithelial-mesenchymal transition via Etk/BMX. Am J Cancer Res. 7:628–646. 2017.PubMed/NCBI

41 

Chu H, Chen X, Wang H, Du Y, Wang Y, Zang W, Li P, Li J, Chang J, Zhao G and Zhang G: MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3. Tumour Biol. 35:3487–3494. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Nie S, Li K, Huang Y, Hu Q, Gao X and Jie S: miR-495 mediates metabolic shift in glioma cells via targeting Glut1. J Craniofac Surg. 26:e155–e158. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Zhang B, Yuan F, Liu J, Li Y, Zhou F, Liu X, Hao Z, Li Q, Zheng Y and Wang W: Hsa-miR-495 acts as a tumor suppressor gene in glioma via the negative regulation of MYB. Mol Med Rep. 14:977–982. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, Feng LY, Tsai HC, Lui TN, Hsueh C and Wei KC: MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6. World J Surg Oncol. 11:872013. View Article : Google Scholar : PubMed/NCBI

45 

Li JZ, Wang ZL, Xu WH, Li Q, Gao L and Wang ZM: MicroRNA-495 regulates migration and invasion in prostate cancer cells via targeting Akt and mTOR signaling. Cancer Invest. 34:181–188. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Song L, Li Y, Li W, Wu S and Li Z: miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A). J Cell Biochem. 115:1234–1242. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Wang YH, Han XD, Qiu Y, Xiong J, Yu Y, Wang B, Zhu ZZ, Qian BP, Chen YX, Wang SF, et al: Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J Surg Oncol. 105:235–243. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Shiratsuchi I, Akagi Y, Kawahara A, Kinugasa T, Romeo K, Yoshida T, Ryu Y, Gotanda Y, Kage M and Shirouzu K: Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer. Anticancer Res. 31:2541–2545. 2011.PubMed/NCBI

49 

Ma Y, Cheng Q, Ren Z, Xu L, Zhao Y, Sun J, Hu S and Xiao W: Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 317:150–156. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Gryko M, Kiśluk J, Cepowicz D, Zińczuk J, Kamocki Z, Guzińska-Ustymowicz K, Pryczynicz A, Czyżewska J, Kemona A and Kędra B: Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer. Pol J Pathol. 65:135–140. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Pengchong H and Tao H: Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma. Eur J Gynaecol Oncol. 32:660–664. 2011.PubMed/NCBI

52 

Xie QX, Lin XC, Zhang MF, Han CX and Guo YH: Expression of IGF-I and IGF-IR in bladder cancer. Ai Zheng. 23:707–709. 2004.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye Y, Zhuang J, Wang G, He S, Zhang S, Wang G, Ni J, Wang J and Xia W: MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432. Exp Ther Med 15: 1150-1158, 2018.
APA
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G. ... Xia, W. (2018). MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432. Experimental and Therapeutic Medicine, 15, 1150-1158. https://doi.org/10.3892/etm.2017.5467
MLA
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G., Ni, J., Wang, J., Xia, W."MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432". Experimental and Therapeutic Medicine 15.1 (2018): 1150-1158.
Chicago
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G., Ni, J., Wang, J., Xia, W."MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1150-1158. https://doi.org/10.3892/etm.2017.5467
Copy and paste a formatted citation
x
Spandidos Publications style
Ye Y, Zhuang J, Wang G, He S, Zhang S, Wang G, Ni J, Wang J and Xia W: MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432. Exp Ther Med 15: 1150-1158, 2018.
APA
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G. ... Xia, W. (2018). MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432. Experimental and Therapeutic Medicine, 15, 1150-1158. https://doi.org/10.3892/etm.2017.5467
MLA
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G., Ni, J., Wang, J., Xia, W."MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432". Experimental and Therapeutic Medicine 15.1 (2018): 1150-1158.
Chicago
Ye, Y., Zhuang, J., Wang, G., He, S., Zhang, S., Wang, G., Ni, J., Wang, J., Xia, W."MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1 Retraction in /10.3892/etm.2022.11432". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1150-1158. https://doi.org/10.3892/etm.2017.5467
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