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Article

Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice

  • Authors:
    • Zhonglin Wu
    • Yuanyuan Zhang
    • Tao Song
    • Qiongtao Song
    • Ying Zhang
    • Xuan Zhang
    • Xue Han
    • Jianping Zhang
    • Li Chu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Pathology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China
  • Pages: 1005-1012
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    Published online on: November 8, 2017
       https://doi.org/10.3892/etm.2017.5470
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Abstract

The present study investigated the effects and potential mechanisms of action of magnesium isoglycyrrhizinate (MgIG) in doxorubicin (DOX)‑treated mice. Histopathological analysis and western blot analysis were conducted in the liver and heart tissues and biochemical analysis of the serum was performed. The results revealed that MgIG (10, 20 and 40 mg/kg/day) could protect the structure and functions of the liver and heart by inhibiting the activities of the myocardial enzymes creatine kinase (CK), CK‑MB and lactate dehydrogenase and the hepatic‑specific enzymes aspirate aminotransferase and alanine aminotransferase, increasing the activities of the antioxidants superoxide dismutase and glutathione peroxidase, and inhibiting cellular apoptosis induced by DOX (30 mg/kg). These results demonstrate that inhibiting lipid peroxidation and reducing myocardial and hepatocyte apoptosis may be one of the mechanisms by which MgIG exhibits hepatoprotective and cardioprotective effects in DOX‑treated mice.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Z, Zhang Y, Song T, Song Q, Zhang Y, Zhang X, Han X, Zhang J and Chu L: Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice. Exp Ther Med 15: 1005-1012, 2018.
APA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X. ... Chu, L. (2018). Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice. Experimental and Therapeutic Medicine, 15, 1005-1012. https://doi.org/10.3892/etm.2017.5470
MLA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15.1 (2018): 1005-1012.
Chicago
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1005-1012. https://doi.org/10.3892/etm.2017.5470
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Z, Zhang Y, Song T, Song Q, Zhang Y, Zhang X, Han X, Zhang J and Chu L: Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice. Exp Ther Med 15: 1005-1012, 2018.
APA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X. ... Chu, L. (2018). Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice. Experimental and Therapeutic Medicine, 15, 1005-1012. https://doi.org/10.3892/etm.2017.5470
MLA
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15.1 (2018): 1005-1012.
Chicago
Wu, Z., Zhang, Y., Song, T., Song, Q., Zhang, Y., Zhang, X., Han, X., Zhang, J., Chu, L."Magnesium isoglycyrrhizinate ameliorates doxorubicin‑induced acute cardiac and hepatic toxicity via anti‑oxidant and anti‑apoptotic mechanisms in mice". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1005-1012. https://doi.org/10.3892/etm.2017.5470
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