Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance

  • Authors:
    • Fei Teng
    • Jinfang Wu
    • Min Wei
    • Yongxiu Yang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Teng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 914-918
    |
    Published online on: November 9, 2017
       https://doi.org/10.3892/etm.2017.5475
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of this study was to investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in umbilical vascular of pregnant women with gestational diabetes mellitus (GDM) and the clinical significance. A total of 103 pregnant women with GDM were selected in the First Hospital of Lanzhou University and the Second Affiliated Hospital of Xi'an Jiaotong University from January 2016 to December 2016 as GDM group. At the same time, 106 normal pregnant women were selected as control group. i) General information of the two groups of pregnant women including age, gestational age, gravida, parity, BMI, systolic blood pressure and diastolic blood pressure were compared; ii) the laboratory indicators of the two groups of pregnant women including fasting blood glucose, glycosylated hemoglobin (HbA1c), umbilical cord arterial pH, partial pressure of oxygen (pO2) and carbon dioxide (pCO2) in umbilical artery were compared; iii) expression of ICAM-1 in umbilical vascular was detected by immunohistochemistry; iv) expression levels of ICAM-1 in umbilical vascular of the two groups of patients were compared. i) There was no significant difference in the age, smoking, gestational age, gravida, parity, BMI, systolic blood pressure and diastolic blood pressure between the two groups (p>0.05); ii) no significant differences in HbA1c, umbilical cord arterial pH, pO2 and pCO2 were found between the groups (p>0.05); iii) ICAM-1 was expressed in umbilical vessels of both groups of pregant women; iv) no significant differences in expression levels of ICAM-1 in umbilical artery and umbilical vein endothelial cells were found between the groups (p>0.05). Therefore, GDM patients with good blood glucose control have no umbilical cord endothelial cell damage.
View Figures

Figure 1

Figure 2

View References

1 

American Diabetes Association, . Standards of medical care in diabetes − 2010. Diabetes Care. 33 Suppl 1:S11–S61. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Kim C: Gestational diabetes mellitus in korean women: Similarities and differences from other racial/ethnic groups. Diabetes Metab J. 38:1–12. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ko GT, Tam WH, Chan JC and Rogers M: Prevalence of gestational diabetes mellitus in Hong Kong based on the 1998 WHO criteria. Diabet Med. 19:802002. View Article : Google Scholar : PubMed/NCBI

4 

Krauss T, Emons G, Kuhn W and Augustin HG: Predictive value of routine circulating soluble endothelial cell adhesion molecule measurements during pregnancy. Clin Chem. 48:1418–1425. 2002.PubMed/NCBI

5 

Bo S, Valpreda S, Menato G, Bardelli C, Botto C, Gambino R, Rabbia C, Durazzo M, Cassader M, Massobrio M, et al: Should we consider gestational diabetes a vascular risk factor? Atherosclerosis. 194:e72–e79. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Ferrara A, Kahn HS, Quesenberry CP, Riley C and Hedderson MM: An increase in the incidence of gestational diabetes mellitus: Northern California, 1991–2000. Obstet Gynecol. 103:526–533. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Getahun D, Nath C, Ananth CV, Chavez MR and Smulian JC: Gestational diabetes in the United States: Temporal trends 1989 through 2004. Am J Obstet Gynecol. 198:525.e1–525.e5. 2008. View Article : Google Scholar

8 

Kaaja RJ and Greer IA: Manifestations of chronic disease during pregnancy. JAMA. 294:2751–2757. 2005. View Article : Google Scholar : PubMed/NCBI

9 

American Diabetes Association, . Gestational diabetes mellitus. Diabetes Care. 27 Suppl 1:S88–S90. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Feig DS, Zinman B, Wang X and Hux JE: Risk of development of diabetes mellitus after diagnosis of gestational diabetes. CMAJ. 179:229–234. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Feng J, Li HY, Wang XL, Huo Y, Liu SX and Li L: Nicotinamide phosphoribosyltransferase enhances beta cell expansion during pregnancy. Eur Rev Med Pharmacol Sci. 20:4965–4971. 2016.PubMed/NCBI

12 

Bellamy L, Casas JP, Hingorani AD and Williams D: Type 2 diabetes mellitus after gestational diabetes: A systematic review and meta-analysis. Lancet. 373:1773–1779. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Coustan DR, Carpenter MW, O'Sullivan PS and Carr SR: Gestational diabetes: Predictors of subsequent disordered glucose metabolism. Am J Obstet Gynecol. 168:1139–1144. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Kjos SL, Peters RK, Xiang A, Henry OA, Montoro M and Buchanan TA: Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing. Diabetes. 44:586–591. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Bloomgarden ZT: Inflammation and insulin resistance. Diabetes Care. 26:1922–1926. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Carr DB, Utzschneider KM, Hull RL, Tong J, Wallace TM, Kodama K, Shofer JB, Heckbert SR, Boyko EJ, Fujimoto WY, et al: Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care. 29:2078–2083. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Seshiah V, Balaji V, Balaji MS, Paneerselvam A, Arthi T, Thamizharasi M and Datta M: Gestational diabetes mellitus manifests in all trimesters of pregnancy. Diabetes Res Clin Pract. 77:482–484. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Yue DK, Molyneaux LM, Ross GP, Constantino MI, Child AG and Turtle JR: Why does ethnicity affect prevalence of gestational diabetes? The underwater volcano theory. Diabet Med. 13:748–752. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Quiñones MJ, Nicholas SB and Lyon CJ: Insulin resistance and the endothelium. Curr Diab Rep. 5:246–253. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Iudakova TN, Girsh AO, Maksimishin SV and Mal'Kov OA: Association of cardiovascular system and endothelial dysfunction indicators in patients with hemorrhagic shock. Anesteziol Reanimatol. 6:11–14. 2013.(In Russian).

21 

Hartge MM, Kintscher U and Unger T: Endothelial dysfunction and its role in diabetic vascular disease. Endocrinol Metab Clin North Am. 35:551–560. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Caballero AE: Endothelial dysfunction, inflammation, and insulin resistance: A focus on subjects at risk for type 2 diabetes. Curr Diab Rep. 4:237–246. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Matsumoto T, Kobayashi T and Kamata K: Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats. Am J Physiol Heart Circ Physiol. 285:H283–H291. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Jiang Y, Jiang LL, Maimaitirexiati XM, Zhang Y and Wu L: Irbesartan attenuates TNF-α-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-κB pathway in HUVECs. Eur Rev Med Pharmacol Sci. 19:3295–3302. 2015.PubMed/NCBI

25 

Imhof BA and Dunon D: Leukocyte migration and adhesion. Adv Immunol. 58:345–416. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Akturk M, Altinova A, Mert I, Dincel A, Sargin A, Buyukkagnici U, Arslan M and Danisman N: Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes. Endocrine. 38:134–141. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kurt M, Zulfikaroglu E, Ucankus NL, Omeroglu S and Ozcan U: Expression of intercellular adhesion molecule-1 in umbilical and placental vascular tissue of gestational diabetic and normal pregnancies. Arch Gynecol Obstet. 281:71–76. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Vastagh I, Horváth T, Garamvölgyi Z, Rosta K, Folyovich A, Rigó J, Kollai M, Bereczki D and Somogyi A: Preserved structural and functional characteristics of common carotid artery in properly treated normoglycemic women with gestational diabetes mellitus. Acta Physiol Hung. 98:294–304. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Bulzico DA, Zajdenverg L, Cabizuca CA, de Oliveira JE and Salles GF: Assessment of arterial stiffness in women with gestational diabetes. Diabet Med. 29:227–231. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Salmi AA, Zaki NM, Zakaria R, Nor Aliza AG and Rasool AH: Arterial stiffness, inflammatory and pro-atherogenic markers in gestational diabetes mellitus. Vasa. 41:96–104. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Teng F, Wu J, Wei M and Yang Y: Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance. Exp Ther Med 15: 914-918, 2018.
APA
Teng, F., Wu, J., Wei, M., & Yang, Y. (2018). Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance. Experimental and Therapeutic Medicine, 15, 914-918. https://doi.org/10.3892/etm.2017.5475
MLA
Teng, F., Wu, J., Wei, M., Yang, Y."Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance". Experimental and Therapeutic Medicine 15.1 (2018): 914-918.
Chicago
Teng, F., Wu, J., Wei, M., Yang, Y."Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance". Experimental and Therapeutic Medicine 15, no. 1 (2018): 914-918. https://doi.org/10.3892/etm.2017.5475
Copy and paste a formatted citation
x
Spandidos Publications style
Teng F, Wu J, Wei M and Yang Y: Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance. Exp Ther Med 15: 914-918, 2018.
APA
Teng, F., Wu, J., Wei, M., & Yang, Y. (2018). Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance. Experimental and Therapeutic Medicine, 15, 914-918. https://doi.org/10.3892/etm.2017.5475
MLA
Teng, F., Wu, J., Wei, M., Yang, Y."Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance". Experimental and Therapeutic Medicine 15.1 (2018): 914-918.
Chicago
Teng, F., Wu, J., Wei, M., Yang, Y."Expression of intercellular adhesion molecule-1 in umbilical vascular of pregnant women with gestational diabetes mellitus and the clinical significance". Experimental and Therapeutic Medicine 15, no. 1 (2018): 914-918. https://doi.org/10.3892/etm.2017.5475
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team