Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow

  • Authors:
    • Hongmei Niu
    • Zhenzhen Wei
    • Yanling Zhang
    • Jian He
    • Danyan Jia
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Shandong Provincial Third Hospital, Jinan, Shandong 250000, P.R. China, Department of Cardiovascular Medicine, The First People's Hospital of Jinan, Jinan, Shandong 250000, P.R. China, Digestive Disease Department of Internal Medicine, The First People's Hospital of Jinan, Jinan, Shandong 250000, P.R. China, Jinan First Aid Center, Jinan, Shandong 250000, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 904-908
    |
    Published online on: November 10, 2017
       https://doi.org/10.3892/etm.2017.5484
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The underlying mechanisms behind the effect of atorvastatin on patients with coronary slow flow (CSF) remain largely unknown. To investigate the possible underlying molecular mechanisms 108 patients were divided into atorvastatin group and control group. Coronary flow was quantified according to corrected TIMI frame count (CTFC). Serum high sensitivity C-reactive protein (hs-CRP), lipids, ET-1, interleukin (IL)-6, NO, circulating endothelial progenitor cell (cEPC) count, adhesion, migration and proliferation were measured in pretreatment and post-treatment. After respective treatment, the atorvastatin group had significantly decreased levels of TC, TG, LDL-C, hs-CRP, ET-1 and IL-6 and increased NO compared to the control group. The atorvastatin group had a more significant improvement of CTFC, effective rate, cEPC number, EPC adhesion, migration and proliferation compared to the control group. In conclusion, atorvastatin can be used in treatment of CSF by suppressing inflammation and improving endothelial function.
View Figures
View References

1 

Hawkins BM, Stavrakis S, Rousan TA, Abu-Fadel M and Schechter E: Coronary slow flow - prevalence and clinical correlations. Circ J. 76:936–942. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Beltrame JF: Defining the coronary slow flow phenomenon. Circ J. 76:818–820. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Tambe AA, Demany MA, Zimmerman HA and Mascarenhas E: Angina pectoris and slow flow velocity of dye in coronary arteries - a new angiographic finding. Am Heart J. 84:66–71. 1972. View Article : Google Scholar : PubMed/NCBI

4 

Cutri N, Zeitz C, Kucia AM and Beltrame JF: ST/T wave changes during acute coronary syndrome presentation in patients with the coronary slow flow phenomenon. Int J Cardiol. 146:457–458. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Horjeti B and Goda A: Acute ischemia manifestation in a patient with coronary slow flow phenomenon. J Electrocardiol. 45:277–279. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Saya S, Hennebry TA, Lozano P, Lazzara R and Schechter E: Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: A case report and review of literature. Clin Cardiol. 31:352–355. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Wang X and Nie SP: The coronary slow flow phenomenon: Characteristics, mechanisms and implications. Cardiovasc Diagn Ther. 1:37–43. 2011.PubMed/NCBI

8 

Yoshida H, Shoda T, Yanai H, Ikewaki K, Kurata H, Ito K, Furutani N, Tada N, Witztum JL and Tsimikas S: Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis. 226:161–164. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, Thomason MJ, Mackness MI, Charlton-Menys V and Fuller JH; CARDS investigators, : Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial. Lancet. 364:685–696. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Caliskan M, Erdogan D, Gullu H, Topcu S, Ciftci O, Yildirir A and Muderrisoglu H: Effects of atorvastatin on coronary flow reserve in patients with slow coronary flow. Clin Cardiol. 30:475–479. 2017. View Article : Google Scholar

11 

Baykan AO, Kalkan GY, Sahin DY, Elbasan Z, Gur M, Seker T, Turkoglu C and Caylı M: Coronary flow velocity reserve in donor artery and myocardial performance index after successful recanalization of chronic total coronary occlusions. J Invasive Cardiol. 27:E75–E81. 2015.PubMed/NCBI

12 

Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, McCabe CH, Raymond L, Fortin T, Poole WK, et al: TIMI frame count: A quantitative method of assessing coronary artery flow. Circulation. 93:879–888. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Nie SP, Wang X, Geng LL, Liu BQ, Li J, Qiao Y, Liu XM, Luo TY, Dong JZ, Liu XH, et al: Anatomic properties of coronary arteries are correlated to the corrected thrombolysis in myocardial infarction frame count in the coronary slow flow phenomenon. Coron Artery Dis. 23:174–180. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Sugiyama M, Ohashi M, Takase H, Sato K, Ueda R and Dohi Y: Effects of atorvastatin on inflammation and oxidative stress. Heart Vessels. 20:133–136. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Bielecka-Dabrowa A, Mikhailidis DP, Rizzo M, von Haehling S, Rysz J and Banach M: The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy − 5-year follow-up. Lipids Health Dis. 12:472013. View Article : Google Scholar : PubMed/NCBI

16 

Kopetz V, Kennedy J, Heresztyn T, Stafford I, Willoughby SR and Beltrame JF: Endothelial function, oxidative stress and inflammatory studies in chronic coronary slow flow phenomenon patients. Cardiology. 121:197–203. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yoon HJ, Jeong MH, Cho SH, Kim KH, Lee MG, Park KH, Sim DS, Yoon NS, Hong YJ, Kim JH, et al: Endothelial dysfunction and increased carotid intima-media thickness in the patients with slow coronary flow. J Korean Med Sci. 27:614–618. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Beltrame JF, Limaye SB, Wuttke RD and Horowitz JD: Coronary hemodynamic and metabolic studies of the coronary slow flow phenomenon. Am Heart J. 146:84–90. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Desjardins F and Balligand JL: Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Clin Belg. 61:326–334. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Toda N, Tanabe S and Nakanishi S: Nitric oxide-mediated coronary flow regulation in patients with coronary artery disease: Recent advances. Int J Angiol. 20:121–134. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Atar S, Ye Y, Lin Y, Freeberg SY, Nishi SP, Rosanio S, Huang MH, Uretsky BF, Perez-Polo JR and Birnbaum Y: Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2. Am J Physiol Heart Circ Physiol. 290:H1960–H1968. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Rajamannan NM, Subramaniam M, Stock SR, Stone NJ, Springett M, Ignatiev KI, McConnell JP, Singh RJ, Bonow RO and Spelsberg TC: Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart. 91:806–810. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Mason RP, Corbalan JJ, Jacob RF, Dawoud H and Malinski T: Atorvastatin enhanced nitric oxide release and reduced blood pressure, nitroxidative stress and rantes levels in hypertensive rats with diabetes. J Physiol Pharmacol. 66:65–72. 2015.PubMed/NCBI

24 

Wu YW, Kao HL, Huang CL, Chen MF, Lin LY, Wang YC, Lin YH, Lin HJ, Tzen KY, Yen RF, et al: The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers. Eur J Nucl Med Mol Imaging. 39:399–407. 2012. View Article : Google Scholar : PubMed/NCBI

25 

van de Ree MA, Huisman MV, Princen HMG, Meinders AE and Kluft C; DALI-Study Group, : Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus. Atherosclerosis. 166:129–135. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Zhang YY, Fan YC, Wang M, Wang D and Li XH: Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer's disease. Clin Interv Aging. 8:103–110. 2013.PubMed/NCBI

27 

Wang H, Cui XX, Goodin S, Ding N, Van Doren J, Du Z, Huang MT, Liu Y, Cheng X, Dipaola RS, et al: Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Oncol Rep. 31:835–841. 2014.PubMed/NCBI

28 

Chang CZ, Wu SC, Lin CL, Hwang SL, Howng SL and Kwan AL: Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats. Acta Neurochir (Wien). 152:1399–1406. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Minami Y, Satoh M, Maesawa C, Takahashi Y, Tabuchi T, Itoh T and Nakamura M: Effect of atorvastatin on microRNA 221/222 expression in endothelial progenitor cells obtained from patients with coronary artery disease. Eur J Clin Invest. 39:359–367. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Oikonomou E, Tousoulis D, Siasos G, Zaromitidou M, Chrysohoou C, Kokkou E, Tourikis P, Mazaris S, Konsola T and Stefanadis C: The impact of high dose atorvastatin treatment on endothelial progenitor cells, vascular function and inflammatory status in ischemic heart failure. Eur Heart J. 34 Suppl 1:P5724. 2013. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Niu H, Wei Z, Zhang Y, He J and Jia D: Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow. Exp Ther Med 15: 904-908, 2018.
APA
Niu, H., Wei, Z., Zhang, Y., He, J., & Jia, D. (2018). Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow. Experimental and Therapeutic Medicine, 15, 904-908. https://doi.org/10.3892/etm.2017.5484
MLA
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15.1 (2018): 904-908.
Chicago
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15, no. 1 (2018): 904-908. https://doi.org/10.3892/etm.2017.5484
Copy and paste a formatted citation
x
Spandidos Publications style
Niu H, Wei Z, Zhang Y, He J and Jia D: Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow. Exp Ther Med 15: 904-908, 2018.
APA
Niu, H., Wei, Z., Zhang, Y., He, J., & Jia, D. (2018). Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow. Experimental and Therapeutic Medicine, 15, 904-908. https://doi.org/10.3892/etm.2017.5484
MLA
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15.1 (2018): 904-908.
Chicago
Niu, H., Wei, Z., Zhang, Y., He, J., Jia, D."Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow". Experimental and Therapeutic Medicine 15, no. 1 (2018): 904-908. https://doi.org/10.3892/etm.2017.5484
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team