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Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage

  • Authors:
    • Zhifa Wang
    • Hongyan Xing
    • Hanqing Hu
    • Taiqiang Dai
    • Yan Wang
    • Zhijin Li
    • Ran An
    • Haiyan Xu
    • Yanpu Liu
    • Bin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Guangzhou General Hospital of Guangzhou Command, Guangzhou, Guangdong 510010, P.R. China, Department of Stomatology, Xinzhou 2nd People's Hospital, Xinzhou, Shaanxi 034100, P.R. China, Department of Stomatology, The 94th Hospital of PLA, Nanchang, Jiangxi 330002, P.R. China, Department of Oral and Maxillofacial Surgery, State Key Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Laboratory Animal Center, State Key Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 795-805
    |
    Published online on: November 13, 2017
       https://doi.org/10.3892/etm.2017.5497
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Abstract

The aim of the present study was to determine the effect of adipose‑derived mesenchymal stem cells (ADSCs) combined with heterologous platelet‑rich fibrin extract (PRFe) on irradiation‑induced salivary gland (SG) damage. ADSCs were isolated from C3H mice, whereas PRFe was obtained from New Zealand rabbits. Twelve weeks post irradiation, the ADSCs or PRFe or their combination were transplanted into the submandibular glands of C3H mice with irradiation‑induced damage. The salivary flow rate (SFR) was determined and histopathological analysis was performed at 12 weeks post transplantation. Immunofluorescence, microvessel density measurements and transmission electron microscopy were performed to assess α‑amylase (AMY) production, apoptosis and microstructural changes in the cells. The administration of ADSCs combined with PRFe increased the SFR at 12 weeks post transplantation, whereas ADSCs alone or PRFe alone failed to do so. The ADSCs+PRFe‑treated, irradiated SGs had fewer damaged and atrophied acinar cells, higher AMY levels and an increased microvessel density compared with the untreated irradiated SGs. Moreover, SG tissue from the ADSCs+PRFe group also showed decreased apoptotic and increased proliferative activity compared to that from the irradiated group. In conclusion, ADSCs or PRFe alone did not restore permanent, irradiation‑induced damage of SG tissue when used alone, but when used together, they provided effective treatment outcomes.
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1 

Pedersen AM, Bardow A, Jensen SB and Nauntofte B: Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 8:117–129. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Vissink A, Burlage FR, Spijkervet FK, Jansma J and Coppes RP: Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med. 14:213–225. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, et al: A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life. Support Care Cancer. 18:1039–1060. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Chambers MS, Garden AS, Kies MS and Martin JW: Radiation-induced xerostomia in patients with head and neck cancer: Pathogenesis, impact on quality of life, and management. Head Neck. 26:796–807. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Zheng C, Cotrim AP, Rowzee A, Swaim W, Sowers A, Mitchell JB and Baum BJ: Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clin Cancer Res. 17:2842–2851. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Arany S, Benoit DS, Dewhurst S and Ovitt CE: Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Mol Ther. 21:1182–1194. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yang TL and Young TH: The enhancement of submandibular gland branch formation on chitosan membranes. Biomaterials. 29:2501–2508. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Soscia DA, Sequeira SJ, Schramm RA, Jayarathanam K, Cantara SI, Larsen M and Castracane J: Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters. Biomaterials. 34:6773–6784. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Joraku A, Sullivan CA, Yoo J and Atala A: In-vitro reconstitution of three-dimensional human salivary gland tissue structures. Differentiation. 75:318–324. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Jean-Gilles R, Soscia D, Sequeira S, Melfi M, Gadre A, Castracane J and Larsen M: Novel modeling approach to generate a polymeric nanofiber scaffold for salivary gland cells. J Nanotechnol Eng Med. 1:310082010. View Article : Google Scholar : PubMed/NCBI

11 

Nanduri LS, Lombaert IM, van der Zwaag M, Faber H, Brunsting JF, van Os RP and Coppes RP: Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland. Radiother Oncol. 108:458–463. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Lombaert IM, Brunsting JF, Wierenga PK, Faber H, Stokman MA, Kok T, Visser WH, Kampinga HH, de Haan G and Coppes RP: Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One. 3:e20632008. View Article : Google Scholar : PubMed/NCBI

13 

Kojima T, Kanemaru S, Hirano S, Tateya I, Ohno S, Nakamura T and Ito J: Regeneration of radiation damaged salivary glands with adipose-derived stromal cells. Laryngoscope. 121:1864–1869. 2011.PubMed/NCBI

14 

Lim JY, Yi T, Choi JS, Jang YH, Lee S, Kim HJ, Song SU and Kim YM: Intraglandular transplantation of bone marrow-derived clonal mesenchymal stem cells for amelioration of post-irradiation salivary gland damage. Oral Oncol. 49:136–143. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Matsumoto S, Okumura K, Ogata A, Hisatomi Y, Sato A, Hattori K, Matsumoto M, Kaji Y, Takahashi M, Yamamoto T, et al: Isolation of tissue progenitor cells from duct-ligated salivary glands of swine. Cloning Stem Cells. 9:176–190. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Tran SD, Liu Y, Xia D, Maria OM, Khalili S, Wang RW, Quan VH, Hu S and Seuntjens J: Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation. PLoS One. 8:e616322013. View Article : Google Scholar : PubMed/NCBI

17 

Gomillion CT and Burg KJ: Stem cells and adipose tissue engineering. Biomaterials. 27:6052–6063. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Lim JY, Ra JC, Shin IS, Jang YH, An HY, Choi JS, Kim WC and Kim YM: Systemic transplantation of human adipose tissue-derived mesenchymal stem cells for the regeneration of irradiation-induced salivary gland damage. PLoS One. 8:e711672013. View Article : Google Scholar : PubMed/NCBI

19 

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J and Gogly B: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:e37–e44. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Sunitha Raja V and Munirathnam Naidu E: Platelet-rich fibrin: Evolution of a second-generation platelet concentrate. Indian J Dent Res. 19:42–46. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Liu B, Tan XY, Liu YP, Xu XF, Li L, Xu HY, An R and Chen FM: The adjuvant use of stromal vascular fraction and platelet-rich fibrin for autologous adipose tissue transplantation. Tissue Eng Part C Methods. 19:1–14. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Sumita Y, Liu Y, Khalili S, Maria OM, Xia D, Key S, Cotrim AP, Mezey E and Tran SD: Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation. Int J Biochem Cell Biol. 43:80–87. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Zwezdaryk KJ, Warner JA, Machado HL, Morris CA and Hönerzu Bentrup K: Rotating cell culture systems for human cell culture: Human trophoblast cells as a model. J Vis Exp. pii:33672012.

24 

Li P, Zhang Y, Wang YM, Duan CM, Hao T, Wu BL and Wang CY: RCCS enhances EOE cell proliferation and their differentiation into ameloblasts. Mol Biol Rep. 39:309–317. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Picken MM: Options for amyloid typing in renal pathology: The advantages of frozen section immunofluorescence and a summary of general recommendations regarding immunohistochemistry methodsAmyloid and Related Disorders. Current Clinical Pathology. Picken M, Herrera G and Dogan A: Humana Press; New York, NY: pp. 283–293. 2015, View Article : Google Scholar

26 

Li Z, Wang Y, Xing HY, Wang Z, Hu H, An R, Xu H, Liu Y and Liu B: Protective efficacy of intravenous transplantation of adipose-derived stem cells for the prevention of radiation-induced salivary gland damage. Arch Oral Biol. 60:1488–1496. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med. 324:1–8. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Baek H, Noh YH, Lee JH, Yeon SI, Jeong J and Kwon H: Autonomous isolation, long-term culture and differentiation potential of adult salivary gland-derived stem/progenitor cells. J Tissue Eng Regen Med. 8:717–727. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhou B, Yuan J, Zhou Y, Ghawji M Jr, Deng YP, Lee AJ, Lee AJ, Nair U, Kang AH, Brand DD and Yoo TJ: Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. Clin Immunol. 141:328–337. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Choi EW, Shin IS, Lee HW, Park SY, Park JH, Nam MH, Kim JS, Woo SK, Yoon EJ, Kang SK, et al: Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. J Gene Med. 13:3–16. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Zhang DZ, Gai LY, Liu HW, Jin QH, Huang JH and Zhu XY: Transplantation of autologous adipose-derived stem cells ameliorates cardiac function in rabbits with myocardial infarction. Chin Med J (Engl). 120:300–307. 2007.PubMed/NCBI

32 

Shevchenko EK, Makarevich PI, Tsokolaeva ZI, Boldyreva MA, Sysoeva VY, Tkachuk VA and Parfyonova YV: Transplantation of modified human adipose derived stromal cells expressing VEGF165 results in more efficient angiogenic response in ischemic skeletal muscle. J Transl Med. 11:1382013. View Article : Google Scholar : PubMed/NCBI

33 

Maria OM and Tran SD: Human mesenchymal stem cells cultured with salivary gland biopsies adopt an epithelial phenotype. Stem Cells Dev. 20:959–967. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Kang SK, Shin IS, Ko MS, Jo JY and Ra JC: Journey of mesenchymal stem cells for homing: Strategies to enhance efficacy and safety of stem cell therapy. Stem Cells Int. 2012:3429682012. View Article : Google Scholar : PubMed/NCBI

35 

Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, et al: Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/β-catenin pathway. Stem Cell Rev. 10:526–538. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Ryan JM, Barry FP, Murphy JM and Mahon BP: Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond). 2:82005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Xing H, Hu H, Dai T, Wang Y, Li Z, An R, Xu H, Liu Y, Liu B, Liu B, et al: Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage. Exp Ther Med 15: 795-805, 2018.
APA
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z. ... Liu, B. (2018). Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage. Experimental and Therapeutic Medicine, 15, 795-805. https://doi.org/10.3892/etm.2017.5497
MLA
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z., An, R., Xu, H., Liu, Y., Liu, B."Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage". Experimental and Therapeutic Medicine 15.1 (2018): 795-805.
Chicago
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z., An, R., Xu, H., Liu, Y., Liu, B."Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage". Experimental and Therapeutic Medicine 15, no. 1 (2018): 795-805. https://doi.org/10.3892/etm.2017.5497
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Xing H, Hu H, Dai T, Wang Y, Li Z, An R, Xu H, Liu Y, Liu B, Liu B, et al: Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage. Exp Ther Med 15: 795-805, 2018.
APA
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z. ... Liu, B. (2018). Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage. Experimental and Therapeutic Medicine, 15, 795-805. https://doi.org/10.3892/etm.2017.5497
MLA
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z., An, R., Xu, H., Liu, Y., Liu, B."Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage". Experimental and Therapeutic Medicine 15.1 (2018): 795-805.
Chicago
Wang, Z., Xing, H., Hu, H., Dai, T., Wang, Y., Li, Z., An, R., Xu, H., Liu, Y., Liu, B."Intraglandular transplantation of adipose‑derived stem cells combined with platelet‑rich fibrin extract for the treatment of irradiation‑induced salivary gland damage". Experimental and Therapeutic Medicine 15, no. 1 (2018): 795-805. https://doi.org/10.3892/etm.2017.5497
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