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Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma

  • Authors:
    • Yan Wei
    • Zhili Zhang
    • Feng Wang
    • Shuihong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of The Medical School of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 649-656
    |
    Published online on: November 13, 2017
       https://doi.org/10.3892/etm.2017.5501
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Abstract

To identify a novel and effective therapy for allergic rhinitis and asthma (ARA), the present study focused on treatment with tumor growth factor (TGF)‑β1 neutralizing antibody. In the present study, four medications were administered to mice with ovalbumin‑induced allergic inflammation. Allergic symptoms in the lungs and nasal mucosa were evaluated by detecting the secretion of cytokines from helper T cells (Th) in the peripheral blood, nasal lavage fluid and bronchoalveolar lavage fluid using ELISA. Defects in regulatory T (Treg) cells in peripheral blood mononuclear cells were also detected using flow cytometry. Furthermore, the expression of TGF‑β1 and activation of Smad2/3 pathways were assessed using immunohistochemical staining, reverse transcription‑quantitative polymerase chain reaction, and western blotting. It was observed that TGF‑β1 neutralizing antibody inhibited symptoms of inflammation in the upper and lower airways. TGF‑β1 neutralizing antibody also restored the Th1/Th2 balance and ameliorated Treg cell defects induced by ARA. Furthermore, the therapeutic effects of TGF‑β1 neutralizing antibody were related to its inhibitory effects on TGF‑β1 expression and Smad2/3 signaling in nasal and lung tissues. Therefore, TGF‑β1 neutralizing antibody may be an effective medicine for the treatment of ARA.
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1 

Bousquet J: Allergic rhinitis and its impact on asthma (ARIA). Clin Exp Allergy Rev. 3:43–45. 2003. View Article : Google Scholar

2 

Peters-Golden M, Gleason MM and Togias A: Cysteinyl leukotrienes: Multi-functional mediators in allergic rhinitis. Clin Exp Allergy. 36:689–703. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Beasley R, Keil U, von Mutius E, Pearce N, Ait-Khaled N, Anabwani G, Anderson HR, Asher MI, Bjorkstein B, Burr ML, et al: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema: ISAAC. Lancet. 351:1225–1232. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Eder W, Ege MJ and von Mutius E: The asthma epidemic. N Engl J Med. 355:2226–2235. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Gerez IF, Lee BW, van Bever HP and Shek LP: Allergies in Asia: Differences in prevalence and management compared with western populations. Expert Rev Clin Immunol. 6:279–289. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Koh YY and Kim CK: The development of asthma in patients with allergic rhinitis. Curr Opin Allergy Clin Immunol. 3:159–164. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Bousquet J, Schünemann HJ, Samolinski B, Demoly P, Baena-Cagnani CE, Bachert C, Bonini S, Boulet LP, Bousquet PJ, Brozek JL, et al: Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs. J Allergy Clin Immunol. 130:1049–1062. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Massagué J: TGF-β signaling in development and disease. FEBS Lett. 586:18332012. View Article : Google Scholar : PubMed/NCBI

10 

Massagué J: TGF-beta signal transduction. Annu Rev Biochem. 67:753–791. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Camoretti-Mercado B and Solway J: Transforming growth factor-beta1 and disorders of the lung. Cell Biochem Biophys. 43:131–148. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Halwani R, Al-Muhsen S, Al-Jahdali H and Hamid Q: Role of transforming growth factor-β in airway remodeling in asthma. Am J Respir Cell Mol Biol. 44:127–133. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Li MO, Wan YY, Sanjabi S, Robertson AK and Flavell RA: Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 24:99–146. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Bellocq A, Azoulay E, Marullo S, Flahault A, Fouqueray B, Philippe C, Cadranel J and Baud L: Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms. Am J Respir Cell Mol Biol. 21:128–136. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Lebman DA and Edmiston JS: The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes. Microbes Infect. 1:1297–1304. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Letterio JJ and Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137–161. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Lúdvíksson BR, Seegers D, Resnick AS and Strober W: The effect of TGF-beta1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells. Eur J Immunol. 30:2101–2111. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Umetsu DT and DeKruyff RH: TH1 and TH2 CD4+ cells in human allergic diseases. J Allergy Clin Immunol. 100:1–6. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Sun YQ, Deng MX, He J, Zeng QX, Wen W, Wong DS, Tse HF, Xu G, Lian Q, Shi J and Fu QL: Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem Cells. 30:2692–2699. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhou K, Liu L and Shi S: Qu Feng Xuan Bi Formula attenuates anaphylactic rhinitis-asthma symptoms via reducing EOS count and regulating T cell function in rat ARA models. J Ethnopharmacol. 152:568–574. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Zhang XF, Zhu J, Geng WY, Zhao SJ, Jiang CW, Cai SR, Cheng M, Zhou CY and Liu ZB: Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease. J Integr Med. 12:417–424. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Fu QL, Chow YY, Sun SJ, Zeng QX, Li HB, Shi JB, Sun YQ, Wen W, Tse HF, Lian Q and Xu G: Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis. Allergy. 67:1215–1222. 2012. View Article : Google Scholar PubMed/NCBI

23 

Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A and Sinigaglia F: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med. 187:129–134. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Strojnik T, Kavalar R, Barone TA and Plunkett RJ: Experimental model and immunohistochemical comparison of U87 human glioblastoma cell xenografts on the chicken chorioallantoic membrane and in rat brains. Anticancer Res. 30:4851–4860. 2010.PubMed/NCBI

25 

Buckner JH: Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol. 10:849–859. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Geissmann F, Revy P, Regnault A, Lepelletier Y, Dy M, Brousse N, Amigorena S, Hermine O and Durandy A: TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol. 162:4567–4575. 1999.PubMed/NCBI

27 

Batra V, Musani AI, Hastie AT, Khurana S, Carpenter KA, Zangrilli JG and Peters SP: Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin Exp Allergy. 34:437–444. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la Rocca AM, Bellia V, Bonsignore G and Bousquet J: Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med. 156:591–599. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Baraniuk JN: Mechanisms of allergic rhinitis. Curr Allergy Asthma Rep. 1:207–217. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Sallusto F, Lanzavecchia A and Mackay CR: Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today. 19:568–574. 1998. View Article : Google Scholar : PubMed/NCBI

31 

Kapsenberg ML, Jansen HM, Bos JD and Wierenga EA: Role of type 1 and type 2 T helper cells in allergic diseases. Curr Opin Immunol. 4:788–793. 1992. View Article : Google Scholar : PubMed/NCBI

32 

Simon HU and Blaser K: Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia? Immunol Today. 16:53–55. 1995. View Article : Google Scholar : PubMed/NCBI

33 

Carballido JM, Carballido-Perrig N, Oberli-Schrämmli A, Heusser CH and Blaser K: Regulation of IgE and IgG4 responses by allergen specific T-cell clones to bee venom phospholipase A2 in vitro. J Allergy Clin Immunol. 93:758–767. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Chatila TA: Role of regulatory T cells in human diseases. J Allergy Clin Immunol. 116:949–959; quiz 960. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Saito S, Nakashima A, Shima T and Ito M: Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol. 63:601–610. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Sakaguchi S, Yamaguchi T, Nomura T and Ono M: Regulatory T cells and immune tolerance. Cell. 133:775–787. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Makinde T, Murphy RF and Agrawal DK: The regulatory role of TGF-beta in airway remodeling in asthma. Immunol Cell Biol. 85:348–356. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Ouyang Y, Miyata M, Hatsushika K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Masuyama K and Nakao A: TGF-beta signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis. Allergol Int. 59:313–319. 2010. View Article : Google Scholar : PubMed/NCBI

39 

He D, Wu L, Kim HK, Li H, Elmets CA and Xu H: CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses. J Immunol. 177:6852–6858. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Rosendahl A, Checchin D, Fehniger TE, ten Dijke P, Heldin CH and Sideras P: Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation. Am J Respir Cell Mol Biol. 25:60–68. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Ge Q, Moir LM, Black JL, Oliver BG and Burgess JK: TGFβ1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells: The role of Smad2/3. J Cell Physiol. 225:846–854. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Cho JY, Doshi A, Rosenthal P, Beppu A, Miller M, Aceves S and Broide D: Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 59:10–16. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Antoni M, Fyhrquist-Vanni N, Wolff H, Alenius H and Lauerma A: Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity. Br J Dermatol. 159:546–554. 2008.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei Y, Zhang Z, Wang F and Zhou S: Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma. Exp Ther Med 15: 649-656, 2018.
APA
Wei, Y., Zhang, Z., Wang, F., & Zhou, S. (2018). Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma. Experimental and Therapeutic Medicine, 15, 649-656. https://doi.org/10.3892/etm.2017.5501
MLA
Wei, Y., Zhang, Z., Wang, F., Zhou, S."Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma". Experimental and Therapeutic Medicine 15.1 (2018): 649-656.
Chicago
Wei, Y., Zhang, Z., Wang, F., Zhou, S."Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma". Experimental and Therapeutic Medicine 15, no. 1 (2018): 649-656. https://doi.org/10.3892/etm.2017.5501
Copy and paste a formatted citation
x
Spandidos Publications style
Wei Y, Zhang Z, Wang F and Zhou S: Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma. Exp Ther Med 15: 649-656, 2018.
APA
Wei, Y., Zhang, Z., Wang, F., & Zhou, S. (2018). Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma. Experimental and Therapeutic Medicine, 15, 649-656. https://doi.org/10.3892/etm.2017.5501
MLA
Wei, Y., Zhang, Z., Wang, F., Zhou, S."Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma". Experimental and Therapeutic Medicine 15.1 (2018): 649-656.
Chicago
Wei, Y., Zhang, Z., Wang, F., Zhou, S."Assessment of tumor growth factor‑β1 neutralizing antibody in the treatment of allergic rhinitis and asthma". Experimental and Therapeutic Medicine 15, no. 1 (2018): 649-656. https://doi.org/10.3892/etm.2017.5501
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