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Article

Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway

  • Authors:
    • Junfeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology and Metabolism, The First Center Hospital of Tianjin, Tianjin 300000, P.R. China
  • Pages: 1087-1092
    |
    Published online on: November 14, 2017
       https://doi.org/10.3892/etm.2017.5511
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Abstract

(‑)‑Epigallocatechin‑3‑gallate (EGCG) is a polyphenol monomer compound extracted and separated from green tea, and is a key catechin in green tea. Recent research has identified that EGCG is equipped with important biological activities, including antitumor, antioxidant, anti‑inflammation, blood fat reduction and radiation protection abilities. In the current study, it was investigated whether EGCG exerts a neuroprotective effect on AIT and examined the possible underlying mechanism. The present study sought to establish an experimental autoimmune thyroiditis (AIT) rat model and to investigate the neuroprotective effect of EGCG in this model. EGCG was demonstrated to inhibit urinary iodine values and thyroid pathological features in AIT model rats. Treatment with EGCG significantly reduced interleukin‑1β, interferon‑γ (INF‑γ) and tumor necrosis factor‑α (TNF‑α) levels in the AIT rats through suppression of nuclear factor‑κB (NF‑κB) pathway. In addition, pretreatment with EGCG significantly increased B‑cell lymphoma‑2 protein expression, and suppressed caspase‑3 activity and TNF‑α‑related apoptosis‑inducing ligand (TRAIL) protein expression levels in the AIT model rats. In conclusion, these results suggested that the neuroprotective effect of EGCG protects against AIT through its anti‑inflammatory ability, anti‑apoptosis and TRAIL signaling pathway in model rats, and it may be used as a therapeutic agent against AIT caused by inflammation.
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1 

Nordio M and Basciani S: Efficacy of a food supplement in patients with hashimoto thyroiditis. J Biol Regul Homeost Agents. 29:93–102. 2015.PubMed/NCBI

2 

Krysiak R and Okopien B: The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto's thyroiditis. J Clin Endocrinol Metab. 96:2206–2215. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Hofling DB, Chavantes MC, Juliano AG, Cerri GG, Romão R, Yoshimura EM and Chammas MC: Low-level laser therapy in chronic autoimmune thyroiditis: A pilot study. Lasers Surg Med. 42:589–596. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Sugiyama A, Zhu BM, Takahara A, Satoh Y and Hashimoto K: Cardiac effects of salvia miltiorrhiza/dalbergia odorifera mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China. Circ J. 66:182–184. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Iwasaki K, Kosaka K, Mori H, Okitsu R, Furukawa K, Manabe Y, Yoshita M, Kanamori A, Ito N, Wada K, et al: Open label trial to evaluate the efficacy and safety of Yokukansan, a traditional Asian medicine, in dementia with Lewy bodies. J Am Geriatr Soc. 59:936–938. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Kristensen B, Hegedüs L, Madsen HO, Smith TJ and Nielsen CH: Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis. Clin Exp Immunol. 180:58–69. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Scarpa V, Kousta E, Tertipi A, Vakaki M, Fotinou A, Petrou V, Hadjiathanasiou C and Papathanasiou A: Treatment with thyroxine reduces thyroid volume in euthyroid children and adolescents with chronic autoimmune thyroiditis. Horm Res Paediatr. 73:61–67. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Vecchiatti SM, Lin CJ, Capelozzi VL, Longatto-Filho A and Bisi H: Prevalence of thyroiditis and immunohistochemistry study searching for a morphologic consensus in morphology of autoimmune thyroiditis in a 4613 autopsies series. Appl Immunohistochem Mol Morphol. 23:402–408. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wang SH, Cao Z, Wolf JM, Van Antwerp M and Baker JR Jr: Death ligand tumor necrosis factor-related apoptosis-inducing ligand inhibits experimental autoimmune thyroiditis. Endocrinology. 146:4721–4726. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Liu H, Zheng T, Mao Y, Xu C, Wu F, Bu L, Mou X, Zhou Y, Yuan G, Wang S, et al: γδ T cells enhance B cells for antibody production in Hashimoto's thyroiditis, and retinoic acid induces apoptosis of the γδ T cell. Endocrine. 51:113–122. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Lee JY, Paik JS, Yun M, Lee SB and Yang SW: The effect of (−)-epigallocatechin-3-gallate on IL-1β induced IL-8 expression in orbital fibroblast from patients with thyroid-associated ophthalmopathy. PLoS One. 11:e01486452016. View Article : Google Scholar : PubMed/NCBI

12 

Liu D, Perkins JT and Hennig B: EGCG prevents PCB-126- induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem. 28:164–170. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Liu Q, Qian Y, Chen F, Chen X, Chen Z and Zheng M: EGCG attenuates pro-inflammatory cytokines and chemokines production in LPS-stimulated L02 hepatocyte. Acta Biochim Biophys Sin (Shanghai). 46:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Cui SL, Yu J and Shoujun L: Iodine intake increases IP-10 expression in the serum and thyroids of rats with experimental autoimmune thyroiditis. Int J Endocrinol. 2014:5810692014. View Article : Google Scholar : PubMed/NCBI

15 

Eguchi K: Apoptosis in autoimmune diseases. Intern Med. 40:275–284. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Arslan S, Korkmaz Ö, Özbilüm N and Berkan Ö: Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease. Biomed Rep. 3:736–740. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Kaczmarek E, Lacka K, Jarmolowska-Jurczyszyn D, Sidor A and Majewski P: Changes of B and T lymphocytes and selected apopotosis markers in Hashimoto's thyroiditis. J Clin Pathol. 64:626–630. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Myśliwiec J, Okota M, Nikołajuk A and Górska M: Soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases: Relation to humoral immune response markers. Adv Med Sci. 51:119–122. 2006.

19 

Mysliwiec J, Okłota M, Nikołajuk A and Górska M: Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases. Endokrynol Pol. 58:492–495. 2007.(In Polish). PubMed/NCBI

20 

Adikesavan G, Vinayagam MM, Abdulrahman LA and Chinnasamy T: (−)-Epigallocatechin-gallate (EGCG) stabilize the mitochondrial enzymes and inhibits the apoptosis in cigarette smoke-induced myocardial dysfunction in rats. Mol Biol Rep. 40:6533–6545. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Bossowski A, Czarnocka B, Bardadin K, Stasiak-Barmuta A, Urban M, Dadan J, Ratomski K and Bossowska A: Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis. Autoimmunity. 41:163–173. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Minatoguchi S, Kariya T, Uno Y, Arai M, Nishida Y, Hashimoto K, Wang N, Aoyama T, Takemura G, Fujiwara T and Fujiwara H: Caspase-dependent and serine protease-dependent DNA fragmentation of myocytes in the ischemia-reperfused rabbit heart: These inhibitors do not reduce infarct size. Jpn Circ J. 65:907–911. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Zhitao J, Long L, Jia L, Yunchao B and Anhua W: Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein. Tumour Biol. 36:9621–9630. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zauli G, Tisato V, Melloni E, Volpato S, Cervellati C, Bonaccorsi G, Radillo O, Marci R and Secchiero P: Inverse correlation between circulating levels of TNF-related apoptosis-inducing ligand and 17β-estradiol. J Clin Endocrinol Metab. 99:E659–E664. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ge Y, Yan D, Deng H, Chen W and An G: Novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in NSCLC cells. Clin Lab. 61:1855–1863. 2015. View Article : Google Scholar : PubMed/NCBI

26 

El-Karaksy SM, Kholoussi NM, Shahin RM, El-Ghar MM and Gheith Rel-S: TRAIL mRNA expression in peripheral blood mononuclear cells of Egyptian SLE patients. Gene. 527:211–214. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhang N, Wang X, Huo Q, Li X, Wang H, Schneider P, Hu G and Yang Q: The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in breast cancer. J Biol Chem. 288:9396–9407. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Ramamurthy V, Yamniuk AP, Lawrence EJ, Yong W, Schneeweis LA, Cheng L, Murdock M, Corbett MJ, Doyle ML and Sheriff S: The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. Acta Crystallogr F Struct Biol Commun. 71:1273–1281. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, Infante-Duarte C, Brocke S and Zipp F: Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol. 173:5794–5800. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J: Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway. Exp Ther Med 15: 1087-1092, 2018.
APA
Li, J. (2018). Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway. Experimental and Therapeutic Medicine, 15, 1087-1092. https://doi.org/10.3892/etm.2017.5511
MLA
Li, J."Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway". Experimental and Therapeutic Medicine 15.1 (2018): 1087-1092.
Chicago
Li, J."Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1087-1092. https://doi.org/10.3892/etm.2017.5511
Copy and paste a formatted citation
x
Spandidos Publications style
Li J: Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway. Exp Ther Med 15: 1087-1092, 2018.
APA
Li, J. (2018). Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway. Experimental and Therapeutic Medicine, 15, 1087-1092. https://doi.org/10.3892/etm.2017.5511
MLA
Li, J."Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway". Experimental and Therapeutic Medicine 15.1 (2018): 1087-1092.
Chicago
Li, J."Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway". Experimental and Therapeutic Medicine 15, no. 1 (2018): 1087-1092. https://doi.org/10.3892/etm.2017.5511
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