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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2018 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Development and identification of Set transgenic mice

  • Authors:
    • Siliang Xu
    • Xiaoqiang Liu
    • Lingling Gao
    • Boqun Xu
    • Jianmin Li
    • Chao Gao
    • Yugui Cui
    • Jiayin Liu

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Reproductive Medicine, Center for Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Obstetrics and Gynecology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1982-1988
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/etm.2017.5612
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Abstract

As a multifunctional protein involved in numerous biological processes, Set is expressed in several embryonic and adult organs. Furthermore, Set is overexpressed in numerous types of human cancers, including acute myeloid leukemia, breast cancer and pancreatic cancer. The expression of Set in germ cells is involved in gonad development, and the overexpression of Set has been observed in polycystic ovaries. In order to elucidate the physiological and pathological roles of Set, a Set transgenic mouse model was developed, in which the global overexpression of Set in adult tissues could be induced via the Cre/loxP system with the precise deletion of the Stop fragment in double‑transgenic hybrids. This result was then confirmed by genotypical and protein analysis using polymerase chain reaction and bioluminescence imaging. In conclusion, the conditional Set transgenic mice carrying a reporter system were successfully generated. The transgenic mice open a new window for the further investigation of the function of Set using tissue‑specific Cre mice and inducible Cre systems.

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Copy and paste a formatted citation
Spandidos Publications style
Xu S, Liu X, Gao L, Xu B, Li J, Gao C, Cui Y and Liu J: Development and identification of Set transgenic mice. Exp Ther Med 15: 1982-1988, 2018.
APA
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C. ... Liu, J. (2018). Development and identification of Set transgenic mice. Experimental and Therapeutic Medicine, 15, 1982-1988. https://doi.org/10.3892/etm.2017.5612
MLA
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C., Cui, Y., Liu, J."Development and identification of Set transgenic mice". Experimental and Therapeutic Medicine 15.2 (2018): 1982-1988.
Chicago
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C., Cui, Y., Liu, J."Development and identification of Set transgenic mice". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1982-1988. https://doi.org/10.3892/etm.2017.5612
Copy and paste a formatted citation
x
Spandidos Publications style
Xu S, Liu X, Gao L, Xu B, Li J, Gao C, Cui Y and Liu J: Development and identification of Set transgenic mice. Exp Ther Med 15: 1982-1988, 2018.
APA
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C. ... Liu, J. (2018). Development and identification of Set transgenic mice. Experimental and Therapeutic Medicine, 15, 1982-1988. https://doi.org/10.3892/etm.2017.5612
MLA
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C., Cui, Y., Liu, J."Development and identification of Set transgenic mice". Experimental and Therapeutic Medicine 15.2 (2018): 1982-1988.
Chicago
Xu, S., Liu, X., Gao, L., Xu, B., Li, J., Gao, C., Cui, Y., Liu, J."Development and identification of Set transgenic mice". Experimental and Therapeutic Medicine 15, no. 2 (2018): 1982-1988. https://doi.org/10.3892/etm.2017.5612
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