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Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction

  • Authors:
    • Yingdi Zhang
    • Zheng Ruan
    • Minhua Shen
    • Luanjun Tan
    • Weiqin Huang
    • Lei Wang
    • Yuanliang Huang
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, East Hospital Affiliated to Tongji University, Shanghai 200120, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2277-2286
    |
    Published online on: January 4, 2018
       https://doi.org/10.3892/etm.2018.5696
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Abstract

The aim of the present study was to evaluate the clinical efficacy of platelet‑rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone‑beam computed tomography was performed immediately and at 3 months following tooth extraction. The changes in alveolar ridge height, width, and bone mineral density were compared between the two groups. The alveolar bone was removed using the ring drill during the implant surgery at 3 months following tooth extraction. Histomorphometric evaluation was performed to compare new bone formation between groups. The patients in the experimental group reportedly felt better compared with the patients in the control group. The healing of gingival tissue was better in the experimental group than in the control group. A significantly greater novel bone area was observed in the PRF group compared with the control group (P<0.01). However, no statistically significant differences were observed in the mean value of buccal alveolar ridge height, lingual/palatal alveolar ridge height and alveolar ridge width between the two groups. These results suggested that PRF was advantageous in human alveolar ridge preservation with ease of use and simple handling. Histological analysis of novel bone formation confirmed that PRF increased the quality of the novel bone and enhanced the rate of bone formation, despite the effect of PRF was not significant to reduce alveolar bone resorption in the extraction socket alone.
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1 

Wood DL, Hoag PM, Donnenfeld OW and Rosenfeld LD: Alveolar crest reduction following full and partial thickness flaps. J Periodontol. 43:141–144. 1972. View Article : Google Scholar : PubMed/NCBI

2 

Ten Heggeler JM, Slot DE and Van der Weijden GA: Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: A systematic review. Clin Oral Implan Res. 22:779–788. 2011. View Article : Google Scholar

3 

Araujo MG and Lindhe J: Ridge alterations following tooth extraction with and without flap elevation: An experimental study in the dog. Clin Oral Implan Res. 20:545–549. 2009.

4 

Wang RE and Lang NP: Ridge preservation after tooth extraction. Clin Oral Implants Res. 23 Suppl 6:S147–S156. 2012. View Article : Google Scholar

5 

Darby I, Chen ST and Buser D: Ridge preservation techniques for implant therapy. Int J Oral Maxillofac Implants. 24 Suppl:S260–S271. 2009.

6 

Bartee BK: Extraction site reconstruction for alveolar ridge preservation. Part. 1:Rationale and materials selection. J Oral Implantol 27: 187–193. 2001.

7 

Serino G, Biancu S, Iezzi G and Piattelli A: Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: A clinical and histological study in humans. Clin Oral Implants Res. 14:651–658. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Brugnami F, Then PR, Moroi H, Kabani S and Leone CW: GBR in human extraction sockets and ridge defects prior to implant placement: Clinical results and histologic evidence of osteoblastic and osteoclastic activities in DFDBA. Int J Periodontics Restorative Dent. 19:259–267. 1999.PubMed/NCBI

9 

Serino G, Biancu S, Iezzi G and Piattelli A: Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: A clinical and histological study in humans. Clin Oral Implan Res. 14:651–658. 2003. View Article : Google Scholar

10 

Yilmaz S, Efeoğlu E and Kiliç AR: Alveolar ridge reconstruction and/or preservation using root form bioglass cones. J Clin Periodontol. 25:832–839. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Gauthier O, Boix D, Grimandi G, Aguado E, Bouler JM, Weiss P and Daculsi G: A new injectable calcium phosphate biomaterial for immediate bone filling of extraction sockets: A preliminary study in dogs. J Periodontol. 70:375–383. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Wang L, Zou D, Zhang S, Zhao J, Pan K and Huang Y: Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor-loaded porous calcium phosphate cement: A pilot study in a canine model. Clin Oral Implants Res. 22:173–181. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Howell TH, Fiorellini J, Jones A, Alder M, Nummikoski P, Lazaro M, Lilly L and Cochran D: A feasibility study evaluating rhBMP-2 absorbable collagen sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restorative Dent. 17:124–139. 1997.PubMed/NCBI

14 

Wang L, Huang Y, Pan K, Jiang X and Liu C: Osteogenic responses to different concentrations/ratios of BMP-2 and bFGF in bone formation. Ann Biomed Eng. 38:77–87. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Dohan Ehrenfest DM: How to optimize the preparation of leukocyte- and platelet-rich fibrin (L-PRF, Choukroun's technique) clots and membranes: Introducing the PRF Box. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 110:275–280. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J and Charrier JB: Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol. 81:546–555. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Li Q, Pan S, Dangaria SJ, Gopinathan G, Kolokythas A, Chu S, Geng Y, Zhou Y and Luan X: Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int. 2013:6380432013.PubMed/NCBI

18 

Anitua E, Alkhraisat MH and Orive G: Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Release. 157:29–38. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J and Dohan DM: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:299–303. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijayalakshmi R and Pameela E: Platelet-rich-fibrin: A novel root coverage approach. J Indian Soc Periodontol. 13:50–54. 2009. View Article : Google Scholar : PubMed/NCBI

21 

He L, Lin Y, Hu X, Zhang Y and Wu H: A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108:707–713. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J and Gogly B: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part III: Leucocyte activation: A new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:e51–e55. 2006. View Article : Google Scholar

23 

Naik B, Karunakar P, Jayadev M and Marshal VR: Role of Platelet rich fibrin in wound healing: A critical review. J Conserv Dent. 16:284–293. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Pripatnanont P, Nuntanaranont T, Vongvatcharanon S and Phurisat K: The primacy of platelet-rich fibrin on bone regeneration of various grafts in rabbit's calvarial defects. J Craniomaxillofac Surg. 41:e191–e200. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Xuan F, Lee CU, Son JS, Jeong SM and Choi BH: A comparative study of the regenerative effect of sinus bone grafting with platelet-rich fibrin-mixed Bio-Oss® and commercial fibrin-mixed Bio-Oss®An experimental study. J Craniomaxillofac Surg. 42:e47–e50. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hoaglin DR and Lines GK: Prevention of localized osteitis in mandibular third-molar sites using platelet-rich fibrin. Int J Dent. 2013:8753802013. View Article : Google Scholar : PubMed/NCBI

27 

Peck MT, Marnewick J and Stephen L: Alveolar ridge preservation using leukocyte and platelet-rich fibrin: A report of a case. Case Rep Dent. 2011:3450482011.PubMed/NCBI

28 

Barone A, Ricci M, Romanos GE, Tonelli P, Alfonsi F and Covani U: Buccal bone deficiency in fresh extraction sockets: A prospective single cohort study. Clin Oral Implants Res. 26:823–830. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Hauser F, Gaydarov N, Badoud I, Vazquez L, Bernard JP and Ammann P: Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: A prospective randomized controlled study. Implant Dent. 22:295–303. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Singh A, Kohli M and Gupta N: Platelet rich fibrin: A novel approach for osseous regeneration. J Maxillofac Oral Surg. 11:430–434. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J and Gogly B: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:e37–e44. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Fickl S, Zuhr O, Wachtel H, Bolz W and Huerzeler M: Tissue alterations after tooth extraction with and without surgical trauma: A volumetric study in the beagle dog. J Clin Periodontol. 35:356–363. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Beck TM and Mealey BL: Histologic analysis of healing after tooth extraction with ridge preservation using mineralized human bone allograft. J Periodontol. 81:1765–1772. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Cypher TJ and Grossman JP: Biological principles of bone graft healing. J Foot Ankle Surg. 35:413–417. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Eriksson C, Ohlson K, Richter K, Billerdahl N, Johansson M and Nygren H: Callus formation and remodeling at titanium implants. J Biomed Mater Res A. 83:1062–1069. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Suttapreyasri S and Leepong N: Influence of Platelet-rich fibrin on alveolar ridge preservation. J Craniofac Surg. 24:1088–1094. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Schropp L, Wenzel A, Kostopoulos L and Karring T: Bone healing and soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 23:313–323. 2003.PubMed/NCBI

38 

Araujo MG and Lindhe J: Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 32:212–218. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Fickl S, Zuhr O, Wachtel H, Stappert CF, Stein JM and Hürzeler MB: Dimensional changes of the alveolar ridge contour after different socket preservation techniques. J Clin Periodontol. 35:906–913. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J and Dohan DM: Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 101:e56–e60. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Ruan Z, Shen M, Tan L, Huang W, Wang L and Huang Y: Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Exp Ther Med 15: 2277-2286, 2018.
APA
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., & Huang, Y. (2018). Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Experimental and Therapeutic Medicine, 15, 2277-2286. https://doi.org/10.3892/etm.2018.5696
MLA
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., Huang, Y."Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction". Experimental and Therapeutic Medicine 15.3 (2018): 2277-2286.
Chicago
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., Huang, Y."Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2277-2286. https://doi.org/10.3892/etm.2018.5696
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Ruan Z, Shen M, Tan L, Huang W, Wang L and Huang Y: Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Exp Ther Med 15: 2277-2286, 2018.
APA
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., & Huang, Y. (2018). Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction. Experimental and Therapeutic Medicine, 15, 2277-2286. https://doi.org/10.3892/etm.2018.5696
MLA
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., Huang, Y."Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction". Experimental and Therapeutic Medicine 15.3 (2018): 2277-2286.
Chicago
Zhang, Y., Ruan, Z., Shen, M., Tan, L., Huang, W., Wang, L., Huang, Y."Clinical effect of platelet-rich fibrin on the preservation of the alveolar ridge following tooth extraction". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2277-2286. https://doi.org/10.3892/etm.2018.5696
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