Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium

  • Authors:
    • Zhixiong Yan
    • Yong Guo
    • Yang Wang
    • Yanan Li
    • Jiahui Wang
  • View Affiliations / Copyright

    Affiliations: College of Biotechnology, Guilin Medical University, Guilin, Guangxi 541100, P.R. China
  • Pages: 2589-2596
    |
    Published online on: January 8, 2018
       https://doi.org/10.3892/etm.2018.5723
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA (miRNA) plays an important role in cell differentiation and functions as a regulator. Therefore, miRNA is important in the process of bone marrow mesenchymal stem cells (BMSCs) being induced into osteoblasts. In this study, mouse BMSCs were induced with osteoinductive medium, the indices related to osteoblastic differentiation were assayed, including alkaline phosphatase, the deposit of calcium and protein levels of osteocalcin. Using miRNA microarray and reverse transcription-quantitative polymerase chain reaction analyses, differentially expressed miRNAs in the cells, which were induced with osteoinductive medium, were selected and identified. The target genes of the differentially expressed miRNAs were then predicted using bioinformatics analysis. The results revealed that osteoinductive medium promoted osteoblastic differentiation of BMSCs, and let‑7c‑5p, miR‑181c‑3p, miR‑3092‑3p and miR‑5132‑3p were identified as differentially expressed miRNAs in the cells treated with osteoinductive medium for 14 and 21 days. Certain target genes and signal pathways related to osteoblastic differentiation of the four miRNAs were predicted. These findings indicated the four differently expressed miRNAs may be potential regulators of osteoblastic differentiation, providing a basis for further study on the regulation of miRNAs in the osteogenic differentiation of BMSCs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, et al: Bone marrow cells regenerate infarcted myocardium. Nature. 410:701–705. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Janssen W, Patel N, et al: Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 164:247–256. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Friedenstein AJ, Chailakhjan RK and Lalykina KS: The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 3:393–403. 1970.PubMed/NCBI

4 

Liu L, Liu M, Li R, Liu H, Du L, Chen H, Zhang Y, Zhang S and Liu D: MicroRNA-503-5p inhibits stretch-induced osteogenic differentiation and bone formation. Cell Biol Int. 41:112–123. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Dong M, Jiao G, Liu H, Wu W, Li S, Wang Q, Xu D, Li X, Liu H and Chen Y: Biological silicon stimulates collagen type 1 and osteocalcin synthesis in human osteoblast-like cells through the BMP-2/Smad/RUNX2 signaling pathway. Biol Trace Elem Res. 173:306–315. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Gao M, Chen J, Lin G, Li S, Wang L, Qin A, Zhao Z, Ren L, Wang Y and Tang BZ: Long-term tracking of the osteogenic differentiation of mouse BMSCs by aggregation-induced emission nanoparticles. ACS Appl Mater Interfaces. 8:17878–17884. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Heino TJ and Hentunen TA: Differentiation of osteoblasts and osteocytes from mesenchymal stem cells. Curr Stem Cell Res Ther. 3:131–145. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Wang C, Meng H, Wang X, Zhao C, Peng J and Wang Y: Differentiation of bone marrow mesenchymal stem cells in osteoblasts and adipocytes and its role in treatment of osteoporosis. Med Sci Monit. 22:226–233. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Zhao Y and Srivastava D: A developmental view of microRNA function. Trends Biochem Sci. 32:189–197. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Stefani G and Slack FJ: Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol. 9:219–230. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent AY, Bak M, Kauppinen S and Kassem M: MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo. Proc Natl Acad Sci USA. 108:pp. 6139–6144. 2011; View Article : Google Scholar : PubMed/NCBI

13 

Li Y, Fan L, Liu S, Liu W, Zhang H, Zhou T, Wu D, Yang P, Shen L, Chen J and Jin Y: The promotion of bone regeneration through positive regulation of angiogenic-osteogenic coupling using microRNA-26a. Biomaterials. 34:5048–5058. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Kim EJ, Kang IH, Lee JW, Jang WG and Koh JT: MiR-433 mediates ERRγ-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells. Life Sci. 92:562–568. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Fang T, Wu Q, Zhou L, Mu S and Fu Q: miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation. Exp Cell Res. 347:74–82. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Deng Y, Wu S, Zhou H, Bi X, Wang Y, Hu Y, Gu P and Fan X: Effects of a miR-31, Runx2, and Satb2 regulatory loop on the osteogenic differentiation of bone mesenchymal stem cells. Stem Cells Dev. 22:2278–2286. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Kuang W, Tan JL, Zhang HM, Duan JM, Wang WJ and Li X: miR-146a down regulates the osteogenic differentiation of murine bone marrow mesenchymal stem cells. Biomed Eng Clin Med. 15:413–417. 2011.(In Chinese).

18 

Coelho MJ and Fernandes MH: Human bone cell cultures in biocompatibility testing. Part II: Effect of ascorbic acid, beta-glycerophosphate and dexamethasone on osteoblastic differentiation. Biomaterials. 21:1095–1102. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Wang B, Li Y, Wang D, Lingling E, Bai Y and Liu H: High glucose inhibits osteogenic differentiation through the BMP signaling pathway in bone mesenchymal stem cells in mice. EXCLI J. 12:584–597. 2013.PubMed/NCBI

20 

Kim K, Dean D, Wallace J, Breithaupt R, Mikos AG and Fisher JP: The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells. Biomaterials. 32:3750–3763. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Liu H, Peng H, Wu Y, Zhang C, Cai Y, Xu G, Li Q, Chen X, Ji J, Zhang Y and OuYang HW: The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrin-BMP/Smad signaling pathway in BMSCs. Biomaterials. 34:4404–4417. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Id Boufker H, Lagneaux L, Fayyad-Kazan H, Badran B, Najar M, Wiedig M, Ghanem G, Laurent G, Body JJ and Journé F: Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts. Bone. 49:1219–1231. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Gronthos S, Akintoye SO, Wang CY and Shi S: Bone marrow stromal stem cells for tissue engineering. Periodontol 2000. 41:188–195. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Chang SC, Chuang HL, Chen YR, Chen JK, Chung HY, Lu YL, Lin HY, Tai CL and Lou J: Ex vivo gene therapy in autologous bone marrow stromal stem cells for tissue-engineered maxillofacial bone regeneration. Gene Ther. 10:2013–2019. 2003. View Article : Google Scholar : PubMed/NCBI

25 

He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, et al: The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA. 102:pp. 19075–19080. 2005; View Article : Google Scholar : PubMed/NCBI

26 

Xu JF, Yang GH, Pan XH, Zhang SJ, Zhao C, Qiu BS, Gu HF, Hong JF, Cao L, Chen Y, et al: Altered MicroRNA expression profile in exosomes during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. PLoS One. 9:e1146272014. View Article : Google Scholar : PubMed/NCBI

27 

Li T, Li H, Wang Y, Li T, Fan J, Xiao K, Zhao RC and Weng X: microRNA-23a inhibits osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting LRP5. Int J Biochem Cell Biol. 72:55–62. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Liu DD, Zhang JC, Zhang Q, Wang SX and Yang MS: TGF-β/BMP signaling pathway is involved in cerium-promoted osteogenic differentiation of mesenchymal stem cells. J Cell Biochem. 114:1105–1114. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Yi C, Liu D, Fong CC, Zhang J and Yang M: Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway. ACS Nano. 4:6439–6448. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Deng ZL, Sharff KA, Tang N, Song WX, Luo J, Luo X, Chen J, Bennett E, Reid R, Manning D, et al: Regulation of osteogenic differentiation during skeletal development. Front Biosci. 13:2001–2021. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Liu Z, Jiang H, Dong K, Liu S, Zhou W, Zhang J, Meng L, Rausch-Fan X and Xu X: Different concentrations of glucose regulate proliferation and osteogenic differentiation of osteoblasts via the PI3 kinase/Akt pathway. Implant Dent. 24:83–91. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Hess K, Ushmorov A, Fiedler J, Brenner RE and Wirth T: TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway. Bone. 45:367–376. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Nakamura A, Dohi Y, Akahane M, Ohgushi H, Nakajima H, Funaoka H and Takakura Y: Osteocalcin secretion as an early marker of in vitro osteogenic differentiation of rat mesenchymal stem cells. Tissue Eng Part C Methods. 15:169–180. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Song I, Kim BS, Kim CS and Im GI: Effects of BMP-2 and vitamin D3 on the osteogenic differentiation of adipose stem cells. Biochem Biophys Res Commun. 408:126–131. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Rodríguez JP, González M, Ríos S and Cambiazo V: Cytoskeletal organization of human mesenchymal stem cells (MSC) changes during their osteogenic differentiation. J Cell Biochem. 93:721–731. 2004. View Article : Google Scholar : PubMed/NCBI

36 

You L, Gu W, Chen L, Pan L, Chen J and Peng Y: MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K/Akt signaling pathway. Int J Clin Exp Pathol. 7:7249–7261. 2014.PubMed/NCBI

37 

Nifuji A, Ideno H, Ohyama Y, Takanabe R, Araki R, Abe M, Noda M and Shibuya H: Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp Cell Res. 316:1127–1136. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Suddason T and Gallagher E: A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1. Cell Death Differ. 22:540–548. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Tanaka K, Matsumoto E, Higashimaki Y, Katagiri T, Sugimoto T, Seino S and Kaji H: Role of osteoglycin in the linkage between muscle and bone. J Biol Chem. 287:11616–11628. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Yeh LC, Tsai AD and Lee JC: Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12. J Cell Biochem. 87:292–304. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Choi HD, Noh WC, Park JW, Lee JM and Suh JY: Analysis of gene expression during mineralization of cultured human periodontal ligament cells. J Periodontal Implant Sci. 41:30–43. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Saeed H, Qiu W, Li C, Flyvbjerg A, Abdallah BM and Kassem M: Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. Biogerontology. 16:733–745. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yan Z, Guo Y, Wang Y, Li Y and Wang J: MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium. Exp Ther Med 15: 2589-2596, 2018.
APA
Yan, Z., Guo, Y., Wang, Y., Li, Y., & Wang, J. (2018). MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium. Experimental and Therapeutic Medicine, 15, 2589-2596. https://doi.org/10.3892/etm.2018.5723
MLA
Yan, Z., Guo, Y., Wang, Y., Li, Y., Wang, J."MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium". Experimental and Therapeutic Medicine 15.3 (2018): 2589-2596.
Chicago
Yan, Z., Guo, Y., Wang, Y., Li, Y., Wang, J."MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2589-2596. https://doi.org/10.3892/etm.2018.5723
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Z, Guo Y, Wang Y, Li Y and Wang J: MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium. Exp Ther Med 15: 2589-2596, 2018.
APA
Yan, Z., Guo, Y., Wang, Y., Li, Y., & Wang, J. (2018). MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium. Experimental and Therapeutic Medicine, 15, 2589-2596. https://doi.org/10.3892/etm.2018.5723
MLA
Yan, Z., Guo, Y., Wang, Y., Li, Y., Wang, J."MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium". Experimental and Therapeutic Medicine 15.3 (2018): 2589-2596.
Chicago
Yan, Z., Guo, Y., Wang, Y., Li, Y., Wang, J."MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2589-2596. https://doi.org/10.3892/etm.2018.5723
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team