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Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies

  • Authors:
    • Su Yu Tang
    • Shun Wen Zhang
    • Jiang Dong Wu
    • Fang Wu
    • Jie Zhang
    • Jiang Tao Dong
    • Peng Guo
    • Da Long Zhang
    • Jun Ting Yang
    • Wan Jiang Zhang
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, P.R. China, Department of First Clinical Medicine, The First School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Pathophysiology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2418-2428
    |
    Published online on: January 9, 2018
       https://doi.org/10.3892/etm.2018.5727
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Abstract

It is currently unknown whether antibiotic monotherapy or combination therapy is a more effective treatment for patients with Pseudomonas aeruginosa bacteraemia. The present study consists of a systematic review and meta‑analysis of cohort studies in associated studies. The treatment options of monotherapy and combination therapy have been compared, to determine which is more effective against P. aeruginosa bacteraemia. Several electronic bibliographic databases were systematically searched and clinical studies that compared combination therapy with monotherapy for P. aeruginosa bacteraemia were identified. Dersimonian and Laird's random‑effects models were used to generate summary estimates of the effects and to assess their association according to different patient characteristics and research quality standards. A total of 17 studies were selected, 3 of which were prospective while the remaining 14 were retrospective. The studies involved a total of 2,504 patients. Significant differences between combination therapy and monotherapy treatment were not found when the data were combined (odds ratio (OR)=0.81, 95% confidence interval (CI)=0.61‑1.08; P=0.035). The results demonstrated strength in a number of stratification and sensitivity analyses. The variables used included study type, treatment quality score and survival rate of subgroup analysis. To conduct cumulative meta‑analysis, the number of years and samples were calculated. The OR value and 95% CI were stable and demonstrated good change trend. According to the size of the sample order following accumulation, OR values and 95% CI (0.89, 0.76‑1.04) exhibited a narrow range. Neither combination therapy or monotherapy exhibited significant effects on the mortality of patients with P. aeruginosa bacteraemia. Future research is required and should include large, well‑designed prospective cohorts, and grouped clinical studies.
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View References

1 

Papagheorghe R: Bloodstream infections in immunocompromised hosts. Roum Arch Microbiol Immunol. 71:87–94. 2012.PubMed/NCBI

2 

Samonis G, Vardakas KZ, Maraki S, Tansarli GS, Dimopoulou D, Kofteridis DP, Andrianaki AM and Falagas ME: A prospective study of characteristics and outcomes of bacteremia in patients with solid organ or hematologic malignancies. Support Care Cancer. 21:2521–2526. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Bassetti M, Righi E and Viscoli C: Pseudomonas aeruginosa serious infections: Mono or combination antimicrobial therapy? Curr Med Chem. 15:517–522. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Garnacho-Montero J, Sa-Borges M, Sole-Violan J, Barcenilla F, Escoresca-Ortega A, Ochoa M, Cayuela A and Rello J: Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: An observational, multicenter study comparing monotherapy with combination antibiotic therapy. Crit Care Med. 35:1888–1895. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Micek ST, Lloyd AE, Ritchie DJ, Reichley RM, Fraser VJ and Kollef MH: Pseudomonas aeruginosa bloodstream infection: Importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother. 49:1306–1311. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Paul M, Benuri-Silbiger I, Soares-Weiser K and Leibovici L: Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: Systematic review and meta-analysis of randomised trials. BMJ. 328:6682004. View Article : Google Scholar : PubMed/NCBI

7 

Morata L, Cobos-Trigueros N, Martínez JA, Soriano A, Almela M, Marco F, Sterzik H, Núñez R, Hernández C and Mensa J: Influence of multidrug resistance and appropriate empirical therapy on the 30-day mortality rate of Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother. 56:4833–4837. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Micek ST, Welch EC, Khan J, Pervez M, Doherty JA, Reichley RM and Kollef MH: Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: A retrospective analysis. Antimicrob Agents Chemother. 54:1742–1748. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Anderson ET, Young LS and Hewitt WL: Antimicrobial synergism in the therapy of gram-negative rod bacteremia. Chemotherapy. 24:45–54. 1978. View Article : Google Scholar : PubMed/NCBI

10 

Chamot E, Boffi El Amari E, Rohner P and Van Delden C: Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother. 47:2756–2764. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Bliziotis IA, Petrosillo N, Michalopoulos A, Samonis G and Falagas ME: Impact of definitive therapy with beta-lactam monotherapy or combination with an aminoglycoside or a quinolone for Pseudomonas aeruginosa bacteremia. PLoS One. 6:e264702011. View Article : Google Scholar : PubMed/NCBI

12 

Bowers DR, Liew YX, Lye DC, Kwa AL, Hsu LY and Tam VH: Outcomes of appropriate empiric combination versus monotherapy for Pseudomonas aeruginosa bacteremia. Antimicrob Agents Chemother. 57:1270–1274. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Deconinck L, Meybeck A, Patoz P, Van Grunderbeeck N, Boussekey N, Chiche A, Delannoy PY, Georges H and Leroy O: Impact of combination therapy and early de-escalation on outcome of ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Infect Dis (Lond). 49:396–404. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Paulsson M, Granrot A, Ahl J, Tham J, Resman F, Riesbeck K and Månsson F: Antimicrobial combination treatment including ciprofloxacin decreased the mortality rate of Pseudomonas aeruginosa bacteraemia: A retrospective cohort study. Eur J Clin Microbiol Infect Dis. 36:1187–1196. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Siegman-Igra Y, Ravona R, Primerman H and Giladi M: Pseudomonas aeruginosa bacteremia: An analysis of 123 episodes, with particular emphasis on the effect of antibiotic therapy. Int J Infect Dis. 2:211–215. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Kim YJ, Jun YH, Yang RK, Park KG, Park YJ, Kang JY and Kim SI: Risk factors for mortality in patients with Pseudomonas aeruginosa bacteremia; retrospective study of impact of combination antimicrobial therapy. BMC Infect Dis. 14:1612014. View Article : Google Scholar : PubMed/NCBI

17 

Samonis G, Vardakas KZ, Kofteridis DP, Dimopoulou D, Andrianaki AM, Chatzinikolaou I, Katsanevaki E, Maraki S and Falagas ME: Characteristics, risk factors and outcomes of adult cancer patients with extensively drug-resistant Pseudomonas aeruginosa infections. Infection. 42:721–728. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Peña C, Suarez C, Ocampo-Sosa A, Murillas J, Almirante B, Pomar V, Aguilar M, Granados A, Calbo E, Rodríguez-Baño J, et al: Effect of adequate single-drug vs combination antimicrobial therapy on mortality in Pseudomonas aeruginosa bloodstream infections: A post Hoc analysis of a prospective cohort. Clin Infect Dis. 57:208–216. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Hilf M, Yu VL, Sharp J, Zuravleff JJ, Korvick JA and Muder RR: Antibiotic therapy for Pseudomonas aeruginosa bacteremia: Outcome correlations in a prospective study of 200 patients. Am J Med. 87:540–546. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Leibovici L, Paul M, Poznanski O, Drucker M, Samra Z, Konigsberger H and Pitlik SD: Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: A prospective, observational study. Antimicrob Agents Chemother. 41:1127–1133. 1997.PubMed/NCBI

21 

Kuikka A and Valtonen VV: Factors associated with improved outcome of Pseudomonas aeruginosa bacteremia in a Finnish university hospital. Eur J Clin Microbiol Infect Dis. 17:701–708. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Mendelson MH, Gurtman A, Szabo S, Neibart E, Meyers BR, Policar M, Cheung TW, Lillienfeld D, Hammer G, Reddy S, et al: Pseudomonas aeruginosa bacteremia in patients with AIDS. Clin Infect Dis. 18:886–895. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Park SY, Park HJ, Song MM, Park KH, Chong YP, Kim MN, Kim SH, Lee SO, Kim YS, Woo JH and Choi SH: Impact of adequate empirical combination therapy on mortality from bacteremic Pseudomonas aeruginosa pneumonia. BMC Infect Dis. 12:3082012. View Article : Google Scholar : PubMed/NCBI

24 

Yoon YK, Kim HA, Ryu SY, Lee EJ, Lee MS, Kim J, Park SY, Yang KS and Kim SW; Antibiotic Stewardship StudyGroup, : Tree-structured survival analysis of patients with Pseudomonas aeruginosa bacteremia: A multicenter observational cohort study. Diagn Microbiol Infect Dis. 87:180–187. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Tan SH, Teng CB, Ng TM and Lye DC: Antibiotic therapy and clinical outcomes of Pseudomonas aeruginosa (PA) bacteraemia. Ann Acad Med Singapore. 43:526–534. 2014.PubMed/NCBI

26 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Yang WS, Va P, Wong MY, Zhang HL and Xiang YB: Soy intake is associated with lower lung cancer risk: Results from a meta-analysis of epidemiologic studies. Am J Clin Nutr. 94:1575–1583. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Yang Y, Zhang D, Feng N, Chen G, Liu J, Chen G and Zhu Y: Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: A meta-analysis. Gastroenterology. 147:1031–1042. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Y, Zheng QJ, Wang S, Zeng SX, Zhang YP, Bai XJ and Hou TY: Diabetes mellitus is associated with increased risk of surgical site infections: A meta-analysis of prospective cohort studies. Am J Infect Control. 43:810–815. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Gu WJ, Wang F, Tang L and Liu JC: Single-dose etomidate does not increase mortality in patients with sepsis: A systematic review and meta-analysis of randomized controlled trials and observational studies. Chest. 147:335–346. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ownby RL, Crocco E, Acevedo A, John V and Loewenstein D: Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry. 63:530–538. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Lo CK, Mertz D and Loeb M: Newcastle-Ottawa Scale: Comparing reviewers' to authors' assessments. BMC Med Res Methodol. 14:452014. View Article : Google Scholar : PubMed/NCBI

33 

Larsson SC, Orsini N and Wolk A: Vitamin B6 and risk of colorectal cancer: A meta-analysis of prospective studies. JAMA. 303:1077–1083. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Higgins JP and Green S: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration; 2011, http://handbook.cochrane.orgMarch. 2011

36 

DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI

37 

Sterne JA and Egger M: Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis. J Clin Epidemiol. 54:1046–1055. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Traugott KA, Echevarria K, Maxwell P, Green K and Lewis JS II: Monotherapy or combination therapy? The Pseudomonas aeruginosa conundrum. Pharmacotherapy. 31:598–608. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Chatzinikolaou I, Abi-Said D, Bodey GP, Rolston KV, Tarrand JJ and Samonis G: Recent experience with Pseudomonas aeruginosa bacteremia in patients with cancer: Retrospective analysis of 245 episodes. Arch Intern Med. 160:501–509. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Safdar N, Handelsman J and Maki DG: Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis. Lancet Infect Dis. 4:519–527. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Y, Chen XL, Huang AW, Liu SL, Liu WJ, Zhang N and Lu XZ: Mortality attributable to carbapenem-resistant Pseudomonas aeruginosa bacteremia: A meta-analysis of cohort studies. Emerg Microbes Infect. 5:e272016. View Article : Google Scholar : PubMed/NCBI

42 

Vardakas KZ, Tansarli GS, Bliziotis IA and Falagas ME: β-Lactam plus aminoglycoside or fluoroquinolone combination versus β-lactam monotherapy for Pseudomonas aeruginosa infections: A meta-analysis. Int J Antimicrob Agents. 41:301–310. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Hu Y, Li L, Li W, Xu H, He P, Yan X and Dai H: Combination antibiotic therapy versus monotherapy for Pseudomonas aeruginosa bacteraemia: A meta-analysis of retrospective and prospective studies. Int J Antimicrob Agents. 42:492–496. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang SY, Zhang SW, Wu JD, Wu F, Zhang J, Dong JT, Guo P, Zhang DL, Yang JT, Zhang WJ, Zhang WJ, et al: Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies. Exp Ther Med 15: 2418-2428, 2018.
APA
Tang, S.Y., Zhang, S.W., Wu, J.D., Wu, F., Zhang, J., Dong, J.T. ... Zhang, W.J. (2018). Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies. Experimental and Therapeutic Medicine, 15, 2418-2428. https://doi.org/10.3892/etm.2018.5727
MLA
Tang, S. Y., Zhang, S. W., Wu, J. D., Wu, F., Zhang, J., Dong, J. T., Guo, P., Zhang, D. L., Yang, J. T., Zhang, W. J."Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies". Experimental and Therapeutic Medicine 15.3 (2018): 2418-2428.
Chicago
Tang, S. Y., Zhang, S. W., Wu, J. D., Wu, F., Zhang, J., Dong, J. T., Guo, P., Zhang, D. L., Yang, J. T., Zhang, W. J."Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2418-2428. https://doi.org/10.3892/etm.2018.5727
Copy and paste a formatted citation
x
Spandidos Publications style
Tang SY, Zhang SW, Wu JD, Wu F, Zhang J, Dong JT, Guo P, Zhang DL, Yang JT, Zhang WJ, Zhang WJ, et al: Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies. Exp Ther Med 15: 2418-2428, 2018.
APA
Tang, S.Y., Zhang, S.W., Wu, J.D., Wu, F., Zhang, J., Dong, J.T. ... Zhang, W.J. (2018). Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies. Experimental and Therapeutic Medicine, 15, 2418-2428. https://doi.org/10.3892/etm.2018.5727
MLA
Tang, S. Y., Zhang, S. W., Wu, J. D., Wu, F., Zhang, J., Dong, J. T., Guo, P., Zhang, D. L., Yang, J. T., Zhang, W. J."Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies". Experimental and Therapeutic Medicine 15.3 (2018): 2418-2428.
Chicago
Tang, S. Y., Zhang, S. W., Wu, J. D., Wu, F., Zhang, J., Dong, J. T., Guo, P., Zhang, D. L., Yang, J. T., Zhang, W. J."Comparison of mono- and combination antibiotic therapy for the treatment of Pseudomonas aeruginosa bacteraemia: A cumulative meta-analysis of cohort studies". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2418-2428. https://doi.org/10.3892/etm.2018.5727
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