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Infectious mononucleosis and hepatic function

  • Authors:
    • Li Zhang
    • Pingping Zhou
    • Zhaowei Meng
    • Chongjie Pang
    • Lu Gong
    • Qing Zhang
    • Qiyu Jia
    • Kun Song
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Health Management, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2901-2909
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    Published online on: January 10, 2018
       https://doi.org/10.3892/etm.2018.5736
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Abstract

Abnormal hepatic function is common in infectious mononucleosis (IM). However, it remains unknown why increased transferase levels are more common than bilirubin abnormalities in IM. The current study aimed to investigate these associations in the Chinese population. A total of 95 patients with IM (47 males and 48 females) were enrolled in the current study, as well as 95 healthy controls. Patients were sorted by sex. A receiver operating characteristic (ROC) curve was used to determine cut‑off values for IM diagnosis and prediction. Crude and adjusted odds ratios (OR) for IM were analyzed using binary logistic regression. It was determined that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ‑glutamyl transferase (GGT) levels were significantly higher in patients with IM compared with controls; however, total bilirubin (TB) levels were significantly lower in patients with IM. ROCs demonstrated that, if ALT, AST and GGT concentrations were higher than, or if TB was lower than, cut‑off values, they were predictive of IM. Binary logistic regression identified that the risk of IM in patients exhibiting high levels of transferases was significantly increased, particularly in males. Crude ORs in ALT quartile 4 were 21.667 and 10.111 for males and females, respectively and adjusted ORs were 38.054 and 9.882, respectively. A significant IM risk of IM was evident in patients with low bilirubin levels and females appeared to be particularly susceptible. For example, crude ORs in quartile 1 were 8.229 and 8.257 for males and females, respectively and adjusted ORs were 8.883 and 10.048, respectively. Therefore, the current study identified a positive association between transferase levels and IM and a negative association between TB and IM. Therefore, the results of the current study indicate that high transferases are suggestive of IM, particularly in males, whereas low TB is suggestive for IM, particularly in females.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Zhou P, Meng Z, Pang C, Gong L, Zhang Q, Jia Q and Song K: Infectious mononucleosis and hepatic function. Exp Ther Med 15: 2901-2909, 2018.
APA
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q. ... Song, K. (2018). Infectious mononucleosis and hepatic function. Experimental and Therapeutic Medicine, 15, 2901-2909. https://doi.org/10.3892/etm.2018.5736
MLA
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q., Jia, Q., Song, K."Infectious mononucleosis and hepatic function". Experimental and Therapeutic Medicine 15.3 (2018): 2901-2909.
Chicago
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q., Jia, Q., Song, K."Infectious mononucleosis and hepatic function". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2901-2909. https://doi.org/10.3892/etm.2018.5736
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Zhou P, Meng Z, Pang C, Gong L, Zhang Q, Jia Q and Song K: Infectious mononucleosis and hepatic function. Exp Ther Med 15: 2901-2909, 2018.
APA
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q. ... Song, K. (2018). Infectious mononucleosis and hepatic function. Experimental and Therapeutic Medicine, 15, 2901-2909. https://doi.org/10.3892/etm.2018.5736
MLA
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q., Jia, Q., Song, K."Infectious mononucleosis and hepatic function". Experimental and Therapeutic Medicine 15.3 (2018): 2901-2909.
Chicago
Zhang, L., Zhou, P., Meng, Z., Pang, C., Gong, L., Zhang, Q., Jia, Q., Song, K."Infectious mononucleosis and hepatic function". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2901-2909. https://doi.org/10.3892/etm.2018.5736
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