Open Access

L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer

  • Authors:
    • Jinlong Chen
    • Fufeng Gao
    • Naifu Liu
  • View Affiliations

  • Published online on: January 12, 2018     https://doi.org/10.3892/etm.2018.5747
  • Pages: 2792-2797
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT with increased formation of CICs in HEC‑1A endometrial cancer cells. CICs and mesenchymal status resist chemotherapeutic drugs and may regenerate the various cell types in tumors, thereby resulting in relapse of the disease. The present study demonstrated that overexpressing L1CAM promoted paclitaxel resistance and regulated paclitaxel resistance‑associated microRNA expression in HEC‑1A cells. Furthermore, it was demonstrated that overexpressing L1CAM promoted anoikis resistance in HEC‑1A cells. This link between L1CAM and EMT/CICs may provide a novel target for advancing anticancer therapy.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen J, Gao F and Liu N: L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer. Exp Ther Med 15: 2792-2797, 2018
APA
Chen, J., Gao, F., & Liu, N. (2018). L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer. Experimental and Therapeutic Medicine, 15, 2792-2797. https://doi.org/10.3892/etm.2018.5747
MLA
Chen, J., Gao, F., Liu, N."L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer". Experimental and Therapeutic Medicine 15.3 (2018): 2792-2797.
Chicago
Chen, J., Gao, F., Liu, N."L1CAM promotes epithelial to mesenchymal transition and formation of cancer initiating cells in human endometrial cancer". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2792-2797. https://doi.org/10.3892/etm.2018.5747