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Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery

  • Authors:
    • Yunbin Xu
    • Yong Li
    • Weiguo Bao
    • Shi Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2869-2873
    |
    Published online on: January 12, 2018
       https://doi.org/10.3892/etm.2018.5750
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Abstract

The aim of the present study was to evaluate the protective effects and safety aspects of recombinant human brain natriuretic peptide (rhBNP) on cardiac functions of patients undergoing open-heart surgery during perioperative period. In total, 150 patients undergoing open heart surgery in the Second Hospital of Shandong Universty from August 2015 to July 2016 were randomly divided into control group and observation group each with 75 cases. Patients in control group were treated by routine rehabilitation while patients in the observation group were treated by both the routine rehabilitation and rhBNP. All the observations were made before operation, after operation and 7 days after operation. The changes of N-terminal pro-brain natriuretic peptide (NT-proBNP) of patients, the left ventricular ejection fraction (LVEF), cardiac function [Cardiac output (CO), pulmonary capillary wedge pressure (PAWP) and central venous pressure (CVP)] of patients were measured. Further, respirator support time, ICU stay time, incidence of complications and vital signs (BP, HR, SaO2) of patients in the two groups were also compared. NT-proBNP levels of all patients improved after operation but it decreased in both groups after 7 days of operation. The decrease of NT-proBNP levels in observation group was significantly higher than that of control group. Whereas, LVEF, CO, PAWP and CVP of patients in both the groups increased after operation but effects were significantly higher in the observation group after 7 days of medication. Respirator support time and ICU stay time of patients in observation group were significantly shorter than those in control group, and the incidence of postoperative complications of patients in the observation group were significantly lower than the control group. Moreover, BP, HR and SaO2 of patients in observation group were significantly elevated in comparison to control group (P<0.05). Recombinant human brain natriuretic peptide (rhBNP) could significantly improve the cardiac functions of patients after open heart surgery, and is safe as well as reliable.
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1 

Pontoni G, Ferrari S, Gabbieri D, Pedulli M, Gambetti D, Ghidoni I and Rigatelli M: FC28-04 - Quality of life assessment after cardiac surgery in octogenarians: Is it really feasible? Eur Psychiatry. 26:19742011.http://www.em-consulte.com/article/289736/fc28-04-quality-of-life-assessment-after-cardiac-s View Article : Google Scholar

2 

Massé L and Antonacci M: Low cardiac output syndrome: Identification and management. Crit Care Nurs Clin North Am. 17:375–383. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Algarni KD, Maganti M and Yau TM: Predictors of low cardiac output syndrome after isolated coronary artery bypass surgery: Trends over 20 years. Ann Thorac Surg. 92:1678–1684. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Mangano DT, Hollenberg M, Fegert G, Meyer ML, London MJ, Tubau JF and Krupski WC: The Study of Perioperative Ischemia (SPI) Research Group: Perioperative myocardial ischemia in patients undergoing noncardiac surgery - I: Incidence and severity during the 4 day perioperative period. J Am Coll Cardiol. 17:843–850. 1991. View Article : Google Scholar : PubMed/NCBI

5 

He XM, Chen L, Luo JB, Feng XX, Zhang YB, Chen QJ, Ji XL and Wang TS: Effects of rhBNP after PCI on non-invasivehemodynamic in acute myocardial infarction patients with left heart failure. Asian Pac J Trop Med. 9:791–795. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Targońska S, Kozioł MM, Czajkowski M, Stążka J and Kozioł-Montewka M: Sternal wound complications after cardiac surgery - a case report. Wiad Lek. 68:95–98. 2015.(In Polish). PubMed/NCBI

7 

Kerneis CK, Lafarge AL, Larnier LL, Scalbert F, Brusset AB, Estagnasie PE and Squara PS: Bowel and related complications after cardiac surgery. Crit Care. 19 Suppl 1:P3752015. View Article : Google Scholar

8 

Howell NJ, Ashrafian H, Drury NE, Ranasinghe AM, Contractor H, Isackson H, Calvert M, Williams LK, Freemantle N, Quinn DW, et al: Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: Results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation. 123:170–177. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Howard BT, Iles TL, Coles JA, Sigg DC and Iaizzo PA: Reversible and irreversible damage of the myocardium: Ischemia/reperfusion injury and cardioprotectionHandbook of Cardiac Anatomy, Physiology, and Devices. 3rd edition. Springer International Publishing; New York: 2015, View Article : Google Scholar

10 

Madamanchi C, Alhosaini H, Sumida A and Runge MS: Obesity and natriuretic peptides, BNP and NT-proBNP: Mechanisms and diagnostic implications for heart failure. Int J Cardiol. 176:611–617. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Oremus M, Don-Wauchope A, McKelvie R, Santaguida PL, Hill S, Balion C, Booth R, Brown JA, Ali U, Bustamam A, et al: BNP and NT-proBNP as prognostic markers in persons with chronic stable heart failure. Heart Fail Rev. 19:471–505. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Boer BP, Vieira ML, Sampaio RO, Abensur H, Oliveira AG, Fernandes JR and Grinberg M: Correlation to NT-ProBNP and remodeling after cardiac surgery. Arq Bras Cardiol. 100:469–475. 2013.PubMed/NCBI

13 

Recombinant Human Brain Natriuretic Peptide Multicenter Clinical Study Group, . Hu DY: Efficacy and safety of intravenous recombinant human brain natriuretic peptide in patients with decompensated acute heart failure: A multicenter, randomized, open label, controlled study. Zhonghua Xin Xue Guan Bing Za Zhi. 39:305–308. 2011.(In Chinese). PubMed/NCBI

14 

Xing K, Fu X, Wang Y, Li W, Gu X, Hao G, Miao Q, Li S, Jiang Y, Fan W, et al: Effect of rhBNP on renal function in STEMI-HF patients with mild renal insufficiency undergoing primary PCI. Heart Vessels. 31:490–498. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Zhang S and Wang Z: Effect of recombinant human brain natriuretic peptide (rhBNP) versus nitroglycerin in patients with heart failure: A systematic review and meta-analysis. Medicine (Baltimore). 95:e47572016. View Article : Google Scholar : PubMed/NCBI

16 

Zhu XQ, Hong HS, Lin XH, Chen LL and Li YH: Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide. Braz J Med Biol Res. 47:646–654. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Zhang J, Zhang L, Wu Q, Liu H and Huang L: Recombinant human brain natriuretic peptide therapy combined with bone mesenchymal stem cell transplantation for treating heart failure in rats. Mol Med Rep. 7:628–632. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Bakkehaug JP, Kildal AB, Engstad ET, Boardman N, Næsheim T, Rønning L, Aasum E, Larsen TS, Myrmel T and How OJ: Response to letter regarding article, ‘Myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity’. Circ Heart Fail. 8:11422015. View Article : Google Scholar : PubMed/NCBI

19 

Lyu T, Zhao Y, Zhang T, Zhou W, Yang F, Ge H, Ding S, Pu J and He B: Natriuretic peptides as an adjunctive treatment for acute myocardial infarction: Insights from the meta-analysis of 1,389 patients from 20 trials. Int Heart J. 55:8–16. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Li Y, Bao W and Qiu S: Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery. Exp Ther Med 15: 2869-2873, 2018.
APA
Xu, Y., Li, Y., Bao, W., & Qiu, S. (2018). Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery. Experimental and Therapeutic Medicine, 15, 2869-2873. https://doi.org/10.3892/etm.2018.5750
MLA
Xu, Y., Li, Y., Bao, W., Qiu, S."Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery". Experimental and Therapeutic Medicine 15.3 (2018): 2869-2873.
Chicago
Xu, Y., Li, Y., Bao, W., Qiu, S."Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2869-2873. https://doi.org/10.3892/etm.2018.5750
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Li Y, Bao W and Qiu S: Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery. Exp Ther Med 15: 2869-2873, 2018.
APA
Xu, Y., Li, Y., Bao, W., & Qiu, S. (2018). Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery. Experimental and Therapeutic Medicine, 15, 2869-2873. https://doi.org/10.3892/etm.2018.5750
MLA
Xu, Y., Li, Y., Bao, W., Qiu, S."Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery". Experimental and Therapeutic Medicine 15.3 (2018): 2869-2873.
Chicago
Xu, Y., Li, Y., Bao, W., Qiu, S."Protective effects of recombinant human brain natriuretic peptide in perioperative period during open heart surgery". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2869-2873. https://doi.org/10.3892/etm.2018.5750
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