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Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis

  • Authors:
    • Yongmei Li
    • Lu Lin
    • Qingxi Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, People's Hospital of Yucheng City, Yucheng, Shandong 251200, P.R. China, Department of Neonatology, People's Hospital of Yucheng City, Yucheng, Shandong 251200, P.R. China, Clinical Laboratory, Jinan Central Hospital, Jinan, Shandong 250013, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2891-2895
    |
    Published online on: January 16, 2018
       https://doi.org/10.3892/etm.2018.5755
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Abstract

This study was designed to investigate the correlation between expression levels of cysteine aspartic protease-3 (caspase-3) and B-cell lymphoma gene-2 (Bcl-2) proteins in alveolar lavage fluid and the prognosis of infants with neonatal respiratory distress syndrome (RDS). A total of 150 infants with neonatal RDS undergoing alveolar lavages were divided into four groups: RDS1 (group A, n=42), RDS2 (group B, n=38), RDS3 (group C, n=38) and RDS4 (group D, n=32) according to their thoracic X-ray film grading. The oxygen uptake score, oxygenation saturation, mean airway pressure and expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid of the infants in the four groups were measured and compared. Our results showed higher grading by thoracic X-rays in patients with increased oxygen uptake score, oxygenation index, mean airway pressure, caspase-3 expression level, hospital stay, complications and death rates in all groups; however, the expression levels of Bcl-2 were decreased in those cases, and the differences had statistical significance among the four groups (P<0.05). Analyses for correlation showed a caspase-3 positive area that was positively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P<0.05); and a Bcl-2 expression level that was negatively correlated with oxygen uptake score, oxygenation index and mean airway pressure (P<0.05). Based on our findings, the severity of neonatal RDS is positively correlated with the concentration of caspase-3 in alveolar lavage fluid, and negatively correlated with the expression level of Bcl-2.
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1 

Frutos-Vivar F, Nin N and Esteban A: Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin Crit Care. 10:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Arakaki R, Yamada A, Kudo Y, Hayashi Y and Ishimaru N: Mechanism of activation-induced cell death of T cells and regulation of FasL expression. Crit Rev Immunol. 34:301–314. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, et al: Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol. 227:81–93. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Liu Q, Si T, Xu X, Liang F, Wang L and Pan S: Electromagnetic radiation at 900 MHz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats. Reprod Health. 12:652015. View Article : Google Scholar : PubMed/NCBI

5 

Crowther CA, Aghajafari F, Askie LM, Asztalos EV, Brocklehurst P, Bubner TK, Doyle LW, Dutta S, Garite TJ, Guinn DA, et al PRECISE Study Group, : Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: Assessing the effects using the best level of evidence) - study protocol. Syst Rev. 1:122012. View Article : Google Scholar : PubMed/NCBI

6 

Sun H, Zhou Y, Xiong H, Kang W, Xu B, Liu D, Zhang X, Li H, Zhou C, Zhang Y, et al: Prognosis of very preterm infants with severe respiratory distress syndrome receiving mechanical ventilation. Lung. 193:249–254. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh S, Andrews J, McClellan S, Wang B and Singh AP: MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. Br J Cancer. 113:660–668. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Takei Y, Okamoto S, Kawamura K, Jiang Y, Morinaga T, Shingyoji M, Sekine I, Kubo S, Tada Y, Tatsumi K, et al: Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells. Cancer Gene Ther. 22:445–453. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Pradeep AR: Expression of key executioner of apoptosis caspase-3 in periodontal health and disease. J Investig Clin Dent. 11:356–358. 2011.

10 

Swamy M, Suhaili D, Sirajudeen KN, Mustapha Z and Govindasamy C: Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain. Afr J Tradit Complement Altern Med. 11:48–53. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Tian F, Fu X, Gao J, Zhang C, Ning Q and Luo X: Caspase-3 mediates apoptosis of striatal cells in GA I rat model. J Huazhong Univ Sci Technolog Med Sci. 32:107–112. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, Nakao A and Toyoda Y: Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun. 408:253–258. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Merido D: Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer. Oncogene. 8:321–323. 2015.

14 

Abdel Shakor AB, Atia M, Alshehri AS, Sobota A and Kwiatkowska K: Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione. Cell Signal. 27:2220–2230. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Adefolaju GA, Theron KE and Hosie MJ: BAX/BCL-2 mRNA and protein expression in human breast MCF-7 cells exposed to drug vehicles-methanol and dimethyl sulfoxide (DMSO) for 24 hours. Niger Med J. 56:169–174. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Aliparasti MR, Alipour MR, Almasi S and Feizi H: Ghrelin administration increases the Bax/Bcl-2 gene expression ratio in the heart of chronic hypoxic rats. Adv Pharm Bull. 5:195–199. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Dagistan Y, Cukur S, Dagistan E and Gezici AR: Importance of IL-6, MMP-1, IGF-1 and BAX levels in lumbar herniated discs and posterior longitudinal ligament in patients with sciatic pain. World Neurosurg. 84:1739–1746. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wright C: S-Nitrosylation of Bcl-2 negatively affects autophagy in lung epithelial cells. J Cell Biochem. 8:102–104. 2015.

19 

Harazono Y, Kho DH, Balan V, Nakajima K, Zhang T, Hogan V and Raz A: Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells. Oncotarget. 5:9992–10001. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Aboutaleb N, Shamsaei N, Khaksari M, Erfani S, Rajabi H and Nikbakht F: Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation. J Physiol Sci. 65:435–443. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Lin L and Wang Q: Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis. Exp Ther Med 15: 2891-2895, 2018.
APA
Li, Y., Lin, L., & Wang, Q. (2018). Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis. Experimental and Therapeutic Medicine, 15, 2891-2895. https://doi.org/10.3892/etm.2018.5755
MLA
Li, Y., Lin, L., Wang, Q."Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis". Experimental and Therapeutic Medicine 15.3 (2018): 2891-2895.
Chicago
Li, Y., Lin, L., Wang, Q."Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2891-2895. https://doi.org/10.3892/etm.2018.5755
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Lin L and Wang Q: Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis. Exp Ther Med 15: 2891-2895, 2018.
APA
Li, Y., Lin, L., & Wang, Q. (2018). Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis. Experimental and Therapeutic Medicine, 15, 2891-2895. https://doi.org/10.3892/etm.2018.5755
MLA
Li, Y., Lin, L., Wang, Q."Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis". Experimental and Therapeutic Medicine 15.3 (2018): 2891-2895.
Chicago
Li, Y., Lin, L., Wang, Q."Correlation of expression levels of caspase-3 and Bcl-2 in alveolar lavage fluid in neonatal respiratory distress syndrome and prognosis". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2891-2895. https://doi.org/10.3892/etm.2018.5755
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