Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients

  • Authors:
    • Mauricio Salinas‑Santander
    • Víctor Trevino
    • Eduardo de la Rosa‑Moreno
    • Bárbara Verduzco‑Garza
    • Celia N. Sánchez‑Domínguez
    • Cristina Cantú‑Salinas
    • Jorge Ocampo‑Garza
    • Armando Lagos‑Rodríguez
    • Jorge Ocampo‑Candiani
    • Rocio Ortiz‑López
  • View Affiliations / Copyright

    Affiliations: Departamento de Bioquímica y Medicina Molecular, Universidad Autónoma de Nuevo León, Facultad de Medicina, Monterrey, Nuevo León 64460, México, Grupo de Investigación en Bioinformática, Escuela de Medicina, Tecnológico de Monterrey, Monterrey, Nuevo León 64849, Mexico, Centro de Investigación y Desarrollo en Ciencias de la Salud, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, Mexico, Servicio de Dermatología, Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Facultad de Medicina, Monterrey, Nuevo León 64460, Mexico
    Copyright: © Salinas‑Santander et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2804-2811
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/etm.2018.5764
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high‑throughput RNA sequencing in a broader set of patients. For microarrays, mRNA was taken from 20 skin biopsies of 10 patients with VV (pigmented and depigmented skin biopsy of each), and 5 biopsies of healthy subjects matched for age and sex were used as a control. A signature was identified that contains the expression pattern of 722 genes between depigmented vitiligo skin vs. healthy control, 1,108 between the pigmented skin of vitiligo vs. healthy controls and 1,927 between pigmented skin, depigmented vitiligo and healthy controls (P<0.05; false discovery rate, <0.1). When comparing the pigmented and depigmented skin of patients with vitiligo, which reflects the real difference between both skin types, 5 differentially expressed genes were identified and further validated in 45 additional VV patients by RNA sequencing. This analysis showed significantly higher RNA levels of calpain‑3, dopachrome tautomerase, melan‑A and tyrosinase‑related protein‑1 genes. The data revealed that the pigmented skin of vitiligo is already affected at the level of gene expression and that the main differences between pigmented and non‑pigmented skin are explained by the expression of genes associated with pigment metabolism.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Steiner D, Bedin V, Moraes MB, Tadeu R and Steiner VT: Vitiligo. An Bras Dermatol. 79:335–351. 2004. View Article : Google Scholar

2 

Parsad D, Dogra S and Kanwar AJ: Quality of life in patients with vitiligo. Health Qual Life Outcomes. 1:582003. View Article : Google Scholar : PubMed/NCBI

3 

Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, et al: Revised classification/nomenclature of vitiligo and related issues: The vitiligo global issues consensus conference. Pigment Cell Melanoma Res. 25:E1–E13. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sehgal VN and Srivastava G: Vitiligo: Compendium of clinico-epidemiological features. Indian J Dermatol Venereol Leprol. 73:149–156. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Spritz RA: The genetics of generalized vitiligo and associated autoimmune diseases. J Dermatol Sci. 41:3–10. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Spritz RA: The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Res. 20:271–278. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Tazi-Ahnini R, McDonagh AJ, Wengraf DA, Lovewell TR, Vasilopoulos Y, Messenger AG, Cork MJ and Gawkrodger DJ: The autoimmune regulator gene (AIRE) is strongly associated with vitiligo. Br J Dermatol. 159:591–596. 2008.PubMed/NCBI

8 

Mohammed GF, Gomaa AH and Al-Dhubaibi MS: Highlights in pathogenesis of vitiligo. World J Clin Cases. 3:221–230. 2015. View Article : Google Scholar : PubMed/NCBI

9 

McCurdy HM: Enzyme localization during melanogenesis. J Cell Biol. 43:220–228. 1969. View Article : Google Scholar : PubMed/NCBI

10 

Lee AY: Role of keratinocytes in the development of vitiligo. Ann Dermatol. 24:115–125. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Slominski A, Ermak G and Wortsman J: Modification of melanogenesis in cultured human melanoma cells. In Vitro Cell Dev Biol Anim. 35:564–565. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Gillbro JM, Marles LK, Hibberts NA and Schallreuter KU: Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol. 123:346–353. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin DJ and White A: Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J. 21:1844–1856. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Kingo K, Aunin E, Karelson M, Philips MA, Rätsep R, Silm H, Vasar E, Soomets U and Kõks S: Gene expression analysis of melanocortin system in vitiligo. J Dermatol Sci. 48:113–122. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Kingo K, Aunin E, Karelson M, Rätsep R, Silm H, Vasar E and Kõks S: Expressional changes in the intracellular melanogenesis pathways and their possible role in the pathogenesis of vitiligo. J Dermatol Sci. 52:39–46. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Nagui NA, Mahmoud SB, Abdel Hay RM, Hassieb MM and Rashed LA: Assessment of gene expression levels of proopiomelanocortin (POMC) and melanocortin-1 receptor (MC1R) in vitiligo. Australas J Dermatol. 58:e36–e39. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Stromberg S, Bjorklund MG, Asplund A, Rimini R, Lundeberg J, Nilsson P, Pontén F and Olsson MJ: Transcriptional profiling of melanocytes from patients with vitiligo vulgaris. Pigment Cell Melanoma Res. 21:162–171. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Royal Stat Soc. 57:289–300. 1995.

20 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Huang da W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Shi F, Kong BW, Song JJ, Lee JY, Dienglewicz RL and Erf GF: Understanding mechanisms of vitiligo development in Smyth line of chickens by transcriptomic microarray analysis of evolving autoimmune lesions. BMC Immunol. 13:182012. View Article : Google Scholar : PubMed/NCBI

23 

Jimbow K, Quevedo WC Jr, Fitzpatrick TB and Szabo G: Some aspects of melanin biology: 1950–1975. J Invest Dermatol. 67:72–89. 1976. View Article : Google Scholar : PubMed/NCBI

24 

Feinmesser M, Tsabari C, Fichman S, Hodak E, Sulkes J and Okon E: Differential expression of proliferation- and apoptosis-related markers in lentigo maligna and solar keratosis keratinocytes. Am J Dermatopathol. 25:300–307. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Baroni A, Buommino E, De Gregorio V, Ruocco E, Ruocco V and Wolf R: Structure and function of the epidermis related to barrier properties. Clin Dermatol. 30:257–262. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Yoshida Y, Hachiya A, Sriwiriyanont P, Ohuchi A, Kitahara T, Takema Y, Visscher MO and Boissy RE: Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types. FASEB J. 21:2829–2839. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Moretti S, Fabbri P, Baroni G, Berti S, Bani D, Berti E, Nassini R, Lotti T and Massi D: Keratinocyte dysfunction in vitiligo epidermis: Cytokine microenvironment and correlation to keratinocyte apoptosis. Histol Histopathol. 24:849–857. 2009.PubMed/NCBI

28 

Regazzetti C, Joly F, Marty C, Rivier M, Mehul B, Reiniche P, Mounier C, Rival Y, Piwnica D, Cavalié M, et al: Transcriptional analysis of vitiligo skin reveals the alteration of wnt pathway: A promising target for repigmenting vitiligo patients. J Invest Dermatol. 135:3105–3114. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Moretti D, Del Bello B, Cosci E, Biagioli M, Miracco C and Maellaro E: Novel variants of muscle calpain 3 identified in human melanoma cells: Cisplatin-induced changes in vitro and differential expression in melanocytic lesions. Carcinogenesis. 30:960–967. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R and Steingrimsson E: Novel MITF targets identified using a two-step DNA microarray strategy. Pigment Cell Melanoma Res. 21:665–676. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Guindalini C, Lee KS, Andersen ML, Santos-Silva R, Bittencourt LR and Tufik S: The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene. Exp Biol Med (Maywood). 235:52–56. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Hubmann G, Guillouet S and Nevoigt E: Gpd1 and Gpd2 fine-tuning for sustainable reduction of glycerol formation in Saccharomyces cerevisiae. Appl Environ Microbiol. 77:5857–5867. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Finotello F and Di Camillo B: Measuring differential gene expression with RNA-seq: Challenges and strategies for data analysis. Brief Funct Genomics. 14:130–142. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Hurd PJ and Nelson CJ: Advantages of next-generation sequencing versus the microarray in epigenetic research. Brief Funct Genomic Proteomic. 8:174–183. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Git A, Dvinge H, Salmon-Divon M, Osborne M, Kutter C, Hadfield J, Bertone P and Caldas C: Systematic comparison of microarray profiling, real-time PCR and next-generation sequencing technologies for measuring differential microRNA expression. RNA. 16:991–1006. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Kloster MB, Bilgrau AE, Rodrigo-Domingo M, Bergkvist KS, Schmitz A, Sønderkær M, Bødker JS, Falgreen S, Nyegaard M, Johnsen HE, et al: A model system for assessing and comparing the ability of exon microarray and tag sequencing to detect genes specific for malignant B-cells. BMC Genomics. 13:5962012. View Article : Google Scholar : PubMed/NCBI

37 

Mastrokolias A, den Dunnen JT, van Ommen GB, 't Hoen PA and van Roon-Mom WM: Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA. BMC Genomics. 13:282012. View Article : Google Scholar : PubMed/NCBI

38 

Gonorazky H, Liang M, Cummings B, Lek M, Micallef J, Hawkins C, Basran R, Cohn R, Wilson MD, MacArthur D, Marshall CR, et al: RNAseq analysis for the diagnosis of muscular dystrophy. Ann Clin Transl Neurol. 3:55–60. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Lesluyes T, Pérot G, Largeau MR, Brulard C, Lagarde P, Dapremont V, Lucchesi C, Neuville A, Terrier P, Vince-Ranchère D, et al: RNA sequencing validation of the Complexity INdex in SARComas prognostic signature. Eur J Cancer. 57:104–111. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Chandrasekharappa SC, Lach FP, Kimble DC, Kamat A, Teer JK, Donovan FX, Flynn E, Sen SK, Thongthip S, Sanborn E, et al: Massively parallel sequencing, aCGH and RNA-Seq technologies provide a comprehensive molecular diagnosis of Fanconi anemia. Blood. 121:e138–e148. 2013. View Article : Google Scholar : PubMed/NCBI

41 

O'Hurley G, Busch C, Fagerberg L, Hallström BM, Stadler C, Tolf A, Lundberg E, Schwenk JM, Jirström K, Bjartell A, et al: Analysis of the human prostate-specific proteome defined by transcriptomics and antibody-based profiling identifies TMEM79 and ACOXL as two putative, diagnostic markers in prostate cancer. PLoS One. 10:e01334492015. View Article : Google Scholar : PubMed/NCBI

42 

Endsley MP, Moyle-Heyrman G, Karthikeyan S, Lantvit DD, Davis DA, Wei JJ and Burdette JE: Spontaneous transformation of murine oviductal epithelial cells: A model system to investigate the onset of fallopian-derived tumors. Front Oncol. 5:1542015. View Article : Google Scholar : PubMed/NCBI

43 

Katayama S, Skoog T, Jouhilahti EM, Siitonen HA, Nuutila K, Tervaniemi MH, Vuola J, Johnsson A, Lönnerberg P, Linnarsson S, et al: Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control. BMC Genomics. 16:4762015. View Article : Google Scholar : PubMed/NCBI

44 

Wang Z, Gerstein M and Snyder M: RNA-Seq: A revolutionary tool for transcriptomics. Nat Rev Genet. 10:57–63. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Swindell WR, Remmer HA, Sarkar MK, Xing X, Barnes DH, Wolterink L, Voorhees JJ, Nair RP, Johnston A, Elder JT and Gudjonsson JE: Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance. Genome Med. 7:862015. View Article : Google Scholar : PubMed/NCBI

46 

Stone RC, Du P, Feng D, Dhawan K, Rönnblom L, Eloranta ML, Donnelly R and Barnes BJ: RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE. PLoS One. 8:e544872013. View Article : Google Scholar : PubMed/NCBI

47 

Shi L, Zhang Z, Yu AM, Wang W, Wei Z, Akhter E, Maurer K, Costa Reis P, Song L, Petri M and Sullivan KE: The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs. PLoS One. 9:e938462014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Salinas‑Santander M, Trevino V, de la Rosa‑Moreno E, Verduzco‑Garza B, Sánchez‑Domínguez CN, Cantú‑Salinas C, Ocampo‑Garza J, Lagos‑Rodríguez A, Ocampo‑Candiani J, Ortiz‑López R, Ortiz‑López R, et al: CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Exp Ther Med 15: 2804-2811, 2018.
APA
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C.N., Cantú‑Salinas, C. ... Ortiz‑López, R. (2018). CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Experimental and Therapeutic Medicine, 15, 2804-2811. https://doi.org/10.3892/etm.2018.5764
MLA
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., Ocampo‑Garza, J., Lagos‑Rodríguez, A., Ocampo‑Candiani, J., Ortiz‑López, R."CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients". Experimental and Therapeutic Medicine 15.3 (2018): 2804-2811.
Chicago
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., Ocampo‑Garza, J., Lagos‑Rodríguez, A., Ocampo‑Candiani, J., Ortiz‑López, R."CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2804-2811. https://doi.org/10.3892/etm.2018.5764
Copy and paste a formatted citation
x
Spandidos Publications style
Salinas‑Santander M, Trevino V, de la Rosa‑Moreno E, Verduzco‑Garza B, Sánchez‑Domínguez CN, Cantú‑Salinas C, Ocampo‑Garza J, Lagos‑Rodríguez A, Ocampo‑Candiani J, Ortiz‑López R, Ortiz‑López R, et al: CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Exp Ther Med 15: 2804-2811, 2018.
APA
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C.N., Cantú‑Salinas, C. ... Ortiz‑López, R. (2018). CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Experimental and Therapeutic Medicine, 15, 2804-2811. https://doi.org/10.3892/etm.2018.5764
MLA
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., Ocampo‑Garza, J., Lagos‑Rodríguez, A., Ocampo‑Candiani, J., Ortiz‑López, R."CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients". Experimental and Therapeutic Medicine 15.3 (2018): 2804-2811.
Chicago
Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., Ocampo‑Garza, J., Lagos‑Rodríguez, A., Ocampo‑Candiani, J., Ortiz‑López, R."CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2804-2811. https://doi.org/10.3892/etm.2018.5764
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team