Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit

Liu,Qiu‑Yue; Han,Fen; Pan,Li‑Ping; Jia,Hong‑Yan; Li,Qi; Zhang,Zong‑De

doi:10.3892/etm.2018.5775

Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit

Authors:
- Qiu‑Yue Liu
- Fen Han
- Li‑Ping Pan
- Hong‑Yan Jia
- Qi Li
- Zong‑De Zhang
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Affiliations: Department of Tuberculosis, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing 101149, P.R. China, Intensive Care Unit, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing 101149, P.R. China, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital Medical University, Beijing 101149, P.R. China
Published online on: January 19, 2018 https://doi.org/10.3892/etm.2018.5775
Pages: 2719-2726
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary tuberculosis caused by Mycobacterium tuberculosis remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary tuberculosis in intensive care units (ICU). The aim of the present study was to investigate the clinical importance of inflammatory cells and factors for patients with pulmonary tuberculosis in ICU. A total of 124 patients with pulmonary tuberculosis in ICU were recruited for the present study. The inflammatory responses in patients with pulmonary tuberculosis in ICU were examined by changes in inflammatory cells and factors in the serum. The results indicated that serum levels of lymphocytes, plasma cells, granulocytes and monocytes were increased in patients with pulmonary tuberculosis in ICU compared with healthy controls. The serum levels of inflammatory factors interleukin (IL)‑1, IL‑6, IL‑10, IL‑12, and IL‑4 were upregulated in patients with pulmonary tuberculosis in ICU. Lower plasma concentrations of IL‑2, IL‑15 and interferon‑γ were detected in patients with pulmonary tuberculosis compared with healthy controls. It was demonstrated that high mobility group box‑1 protein expression levels were higher in the serum of patients with pulmonary tuberculosis compared with healthy controls. Notably, an imbalance of T‑helper cell (Th)1/Th2 cytokines was observed in patients with pulmonary tuberculosis. Pulmonary tuberculosis caused by M. tuberculosis also upregulated expression of matrix metalloproteinase (MMP)‑1 and MMP‑9 in hPMCs. In conclusion, these outcomes demonstrated that inflammatory responses and inflammatory factors are associated with the progression of pulmonary tuberculosis, suggesting that inhibition of inflammatory responses and inflammatory factors may be beneficial for the treatment of patients with pulmonary tuberculosis in ICU.

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