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Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease

  • Authors:
    • Lei Yang
    • Xingai Jiao
    • Jinxiang Wu
    • Jiping Zhao
    • Tian Liu
    • Jianfeng Xu
    • Xiaohui Ma
    • Liuzao Cao
    • Lin Liu
    • Yahui Liu
    • Jingyu Chi
    • Minfang Zou
    • Shuo Li
    • Jiawei Xu
    • Liang Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Tuberculosis, Shandong Provincial Chest Hospital, Jinan, Shandong 250013, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2731-2738
    |
    Published online on: January 19, 2018
       https://doi.org/10.3892/etm.2018.5777
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Abstract

Cordyceps sinensis is a traditional Chinese herbal medicine that has been used for centuries in Asia as a tonic to soothe the lung for the treatment of respiratory diseases. The aim of the present study was to determine the effects of C. sinensis on airway remodeling in chronic obstructive pulmonary disease (COPD) and investigate the underlying molecular mechanisms. Rats with COPD were orally administered C. sinensis at low, moderate or high doses (2.5, 5 or 7.5 g/kg/day, respectively) for 12 weeks. Airway tissue histopathology, lung inflammation and airway remodeling were evaluated. C. sinensis treatment significantly ameliorated airway wall thickening, involving collagen deposition, airway wall fibrosis, smooth muscle hypertrophy and epithelial hyperplasia in model rats with COPD. Additionally, C. sinensis administration in rats with COPD reduced inflammatory cell accumulation and decreased inflammatory cytokine production, including tumor necrosis factor‑α, interleukin‑8 and transforming growth factor (TGF)‑β1 in bronchoalveolar lavage fluid. Meanwhile, the increased levels of α‑smooth muscle actin and collagen I in the COPD group were also markedly decreased by C. sinensis treatment. Furthermore, compared with untreated rats with COPD, C. sinensis reduced the expression level of phosphorylated (p)‑Smad2, p‑Smad3, TGF‑β1 and its receptors, with the concomitant increased expression of Smad7 in the lungs of rats with COPD. These results indicated that treatment with C. sinensis may be a useful approach for COPD therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Jiao X, Wu J, Zhao J, Liu T, Xu J, Ma X, Cao L, Liu L, Liu Y, Liu Y, et al: Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Exp Ther Med 15: 2731-2738, 2018.
APA
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J. ... Dong, L. (2018). Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 15, 2731-2738. https://doi.org/10.3892/etm.2018.5777
MLA
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J., Ma, X., Cao, L., Liu, L., Liu, Y., Chi, J., Zou, M., Li, S., Xu, J., Dong, L."Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15.3 (2018): 2731-2738.
Chicago
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J., Ma, X., Cao, L., Liu, L., Liu, Y., Chi, J., Zou, M., Li, S., Xu, J., Dong, L."Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2731-2738. https://doi.org/10.3892/etm.2018.5777
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Jiao X, Wu J, Zhao J, Liu T, Xu J, Ma X, Cao L, Liu L, Liu Y, Liu Y, et al: Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Exp Ther Med 15: 2731-2738, 2018.
APA
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J. ... Dong, L. (2018). Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease. Experimental and Therapeutic Medicine, 15, 2731-2738. https://doi.org/10.3892/etm.2018.5777
MLA
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J., Ma, X., Cao, L., Liu, L., Liu, Y., Chi, J., Zou, M., Li, S., Xu, J., Dong, L."Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15.3 (2018): 2731-2738.
Chicago
Yang, L., Jiao, X., Wu, J., Zhao, J., Liu, T., Xu, J., Ma, X., Cao, L., Liu, L., Liu, Y., Chi, J., Zou, M., Li, S., Xu, J., Dong, L."Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2731-2738. https://doi.org/10.3892/etm.2018.5777
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