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Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease

  • Authors:
    • Jianhai Zhang
    • Jian Hu
    • Chunxia Zhang
    • Yanni Jiao
    • Xiang Kong
    • Wei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4259-4264
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/etm.2018.5932
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Abstract

The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group. The differences of clinical, biochemical and metabolic indexes were compared. The levels of luteinizing hormone (LH), LH/follicle stimulating hormone (FSH), testosterone (T), free androgen index (FAI), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA‑IR) index in PCOS group were higher than those in normal control group, but the sex hormone binding globulin (SHBG) level was lower than that in normal control group (p<0.05); there were no statistically significant differences in comparisons of age, body mass index (BMI), waist-hip ratio (WHR), FSH, dehydroepiandrosterone sulfate (DHEAs) and fasting blood glucose (FBG) between the two groups (p>0.05).The prevalence rate of NAFLD in PCOS group (44.68%) was significantly higher than that in control group (24.62%) (p<0.05). The proportion of NAFLD in PCOS patients in obesity group (63.51%) was significantly higher than that in non-obesity group (15.79%) (p<0.05). In PCOS group, NAFLD patients had more obvious metabolic abnormalities [high BMI, WHR, FBG, FINS, HOMA-IR index, total cholesterol (TC) and triglyceride (TG), and low high-density lipoprotein HDL and SHBG] and androgen excess compared with those in N-NAFLD patients (p<0.05). The levels of LH, LH/FSH, FINS and HOMA-IR index in PCOS group complicated with NAFLD were higher than those in control group complicated with NAFLD (p<0.05), but the differences in age, BMI, WHR, FSH and FBG levels were not statistically significant between the two groups (p>0.05). HOMA-IR index, BMI, WHR and TG were independent risk factors for PCOS complicated with NAFLD (p<0.05).
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Hu J, Zhang C, Jiao Y, Kong X and Wang W: Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease. Exp Ther Med 15: 4259-4264, 2018.
APA
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., & Wang, W. (2018). Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease. Experimental and Therapeutic Medicine, 15, 4259-4264. https://doi.org/10.3892/etm.2018.5932
MLA
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., Wang, W."Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease". Experimental and Therapeutic Medicine 15.5 (2018): 4259-4264.
Chicago
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., Wang, W."Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4259-4264. https://doi.org/10.3892/etm.2018.5932
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Hu J, Zhang C, Jiao Y, Kong X and Wang W: Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease. Exp Ther Med 15: 4259-4264, 2018.
APA
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., & Wang, W. (2018). Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease. Experimental and Therapeutic Medicine, 15, 4259-4264. https://doi.org/10.3892/etm.2018.5932
MLA
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., Wang, W."Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease". Experimental and Therapeutic Medicine 15.5 (2018): 4259-4264.
Chicago
Zhang, J., Hu, J., Zhang, C., Jiao, Y., Kong, X., Wang, W."Analyses of risk factors for polycystic ovary syndrome complicated with non-alcoholic fatty liver disease". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4259-4264. https://doi.org/10.3892/etm.2018.5932
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