Open Access

Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage

  • Authors:
    • Jia‑Chen Cai
    • Wei Liu
    • Fei Lu
    • Wen‑Bing Kong
    • Xin‑Xuan Zhou
    • Peng Miao
    • Cheng‑Xiang Lei
    • Yan Wang
  • View Affiliations

  • Published online on: March 8, 2018     https://doi.org/10.3892/etm.2018.5938
  • Pages: 4131-4138
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Resveratrol (RESV) improves histopathological and behavioral outcomes in diseases of the central nervous system. However, to the best of our knowledge, there have been no studies investigating its neuroprotective effects on secondary brain injury following intracerebral hemorrhage (ICH). The aim of the present study was to evaluate the neuroprotective function of resveratrol following ICH. Male Sprague‑Dawley rats were randomly divided into 3 groups: Sham, ICH and ICH+RESV groups. Rats underwent ICH and received an intraperitoneal injection of RESV daily. Rotarod and open field tests were performed to evaluate improvements in motor disturbance pre‑ and post‑surgery. Rats were sacrificed following the final behavioral test; subsequently, neuron injury and cell death in the hippocampus and microglia activation in the cortex were determined using Nissl staining and ionized calcium binding adaptor molecule 1 immunofluorescence staining, respectively. Compared with the ICH group, rats treated with resveratrol for 2 weeks performed significantly better in behavioral tests. Furthermore, less neural damage in the hippocampus and decreased activation of microglia was observed in the ICH+RESV group. The results of the present study therefore indicate that resveratrol may alleviate secondary brain injury following ICH.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cai JC, Liu W, Lu F, Kong WB, Zhou XX, Miao P, Lei CX and Wang Y: Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage. Exp Ther Med 15: 4131-4138, 2018
APA
Cai, J., Liu, W., Lu, F., Kong, W., Zhou, X., Miao, P. ... Wang, Y. (2018). Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage. Experimental and Therapeutic Medicine, 15, 4131-4138. https://doi.org/10.3892/etm.2018.5938
MLA
Cai, J., Liu, W., Lu, F., Kong, W., Zhou, X., Miao, P., Lei, C., Wang, Y."Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage". Experimental and Therapeutic Medicine 15.5 (2018): 4131-4138.
Chicago
Cai, J., Liu, W., Lu, F., Kong, W., Zhou, X., Miao, P., Lei, C., Wang, Y."Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4131-4138. https://doi.org/10.3892/etm.2018.5938