Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway

  • Authors:
    • Xiaohong Wang
    • Dan Li
    • Yong Zhang
    • Shuang Wu
    • Fang Tang
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/etm.2018.5946
  • Pages: 4477-4484
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Abstract

Ulcerative colitis is a chronic nonspecific inflammatory disease that occurs in the colon and rectum. Costus root is a type of traditional Chinese medicine that exhibits antibacterial properties and serves an inhibitory role in the regeneration of gut bacteria. However, the molecular mechanisms underlying Costus root‑mediated improvements in ulcerative colitis remain unclear. A complex formula of Costus root granules was created and investigated in the present study for its therapeutic effects in a rat model of ulcerative colitis. Ingredient dissolution into a traditional water decoction was used as a control. The potential mechanism mediated by Costus root granules was also analyzed in colonic epithelial cells isolated from the experimental rats. The results of the present study demonstrated that Costus root granule treatment inhibited inflammation in colonic tissue. Costus root granule treatment also suppressed the apoptosis of colonic epithelial cells isolated from the rat model of ulcerative colitis. Analyses of the underlying mechanisms of these effects indicated that the administration of Costus root granules increased transforming growth factor β expression, which activated the phosphoinositide 3‑kinase/RAC‑α serine/threonine‑protein kinase signaling pathway in colonic epithelial cells. Notably, the administration of Costus root granules improved stomachache, diarrhea and hematochezia in and increased the body weight of, the ulcerative colitis rats. In conclusion, these results indicate that Costus root granules markedly ameliorate inflammation of the colonic epithelium, decrease the apoptosis of colonic epithelial cells and improve colonic function, which suggests that Costus root granules are an efficient agent for the treatment of ulcerative colitis.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang X, Li D, Zhang Y, Wu S and Tang F: Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway. Exp Ther Med 15: 4477-4484, 2018
APA
Wang, X., Li, D., Zhang, Y., Wu, S., & Tang, F. (2018). Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 15, 4477-4484. https://doi.org/10.3892/etm.2018.5946
MLA
Wang, X., Li, D., Zhang, Y., Wu, S., Tang, F."Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 15.5 (2018): 4477-4484.
Chicago
Wang, X., Li, D., Zhang, Y., Wu, S., Tang, F."Costus root granules improve ulcerative colitis through regulation of TGF-β mediation of the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4477-4484. https://doi.org/10.3892/etm.2018.5946