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Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit

  • Authors:
    • Qinhao Li
    • Xiaona Gong
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, Qilu Hospital of Shandong University in Dongying, Dongying, Shandong 257000, P.R. China, Department of Emergency, Qilu Hospital of Shandong University in Dongying, Dongying, Shandong 257000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4265-4270
    |
    Published online on: March 15, 2018
       https://doi.org/10.3892/etm.2018.5960
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Abstract

The identification significance of C-reactive protein (CRP) and procalcitonin (PCT) levels in the intensive care unit patients with combined infection and their prognostic effects of patients with sepsis was investigated. A total of 203 patients were divided into the sepsis (n=60) and the non-sepsis group (n=143). The predictive effects of CRP and PCT levels in patients in the intensive care unit on sepsis and their effects on the prognosis of patients with sepsis were analyzed. The results showed that CRP and PCT levels in patients in the sepsis were higher than those in the non-sepsis group (p<0.05); CRP and PCT levels in patients who died of sepsis at 1 week and 2 weeks after admission were not statistically different to those before admission (p>0.05); CRP and PCT levels in patients surviving sepsis at 1 week after admission were significantly decreased compared with those at admission (p<0.05). CRP and PCT levels in patients at 2 weeks after admission were significantly decreased compared with those at admission (p<0.05). CRP and PCT levels in patients who died of sepsis were higher than those surviving sepsis (p<0.05). Logistic regression analysis showed that the higher the CRP and PCT levels were, the worse the patients' conditions would be, and the higher the risk of death would be (r=0.732, p=0.012; r=0.826, p=0.007); besides, PCT had a higher value in predicting the poor prognosis of patients [PCT: Area under the curve (AUC)=0.734, CRP: AUC=0.699]; the univariate Cox regression analysis revealed that CRP, PCT and age may be the risk factors for poor prognosis in patients. CRP and PCT can be used to identify whether the patients in the intensive care unit are infected or not. The dynamic monitoring of CRP and PCT has important clinical significance in predicting the prognosis of patients with sepsis.
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1 

Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW and Biswal S: Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 116:984–995. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Agyeman PKA, Schlapbach LJ, Giannoni E, Stocker M, Posfay-Barbe KM, Heininger U, Schindler M, Korten I, Konetzny G, Niederer-Loher A, et al: Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. Lancet Child Adolesc Health. 1:123–133. 2017. View Article : Google Scholar

3 

Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW and Biswal S: Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest. 116:984–995. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Kaukonen KM, Bailey M, Suzuki S, Pilcher D and Bellomo R: Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 311:1308–1316. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP, Artigas A, Schorr C and Levy MM: Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program. Crit Care Med. 42:1749–1755. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Vincent JL, Opal SM, Marshall JC and Tracey KJ: Sepsis definitions: Time for change. Lancet. 381:774–775. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Liu V, Escobar GJ, Greene JD, Soule J, Whippy A, Angus DC and Iwashyna TJ: Hospital deaths in patients with sepsis from 2 independent cohorts. JAMA. 312:90–92. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, et al: ALBIOS Study Investigators: Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 370:1412–1421. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Yang AP, Liu J, Yue LH, Wang HQ, Yang WJ and Yang GH: Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis. Clin Chem Lab Med. 54:345–351. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Henriquez-Camacho C and Losa J: Biomarkers for sepsis. BioMed Res Int. 2014:5478182014. View Article : Google Scholar : PubMed/NCBI

11 

Gao L, Liu X, Zhang D, Xu F, Chen Q, Hong Y, Feng G, Shi Q, Yang B and Xu L: Early diagnosis of bacterial infection in patients with septicopyemia by laboratory analysis of PCT, CRP and IL-6. Exp Ther Med. 13:3479–3483. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y and Zhou L: Diagnostic value of C-reactive protein and procalcitonin for bacterial infection in acute exacerbations of chronic obstructive pulmonary disease. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 39:939–943. 2014.(In Chinese). PubMed/NCBI

13 

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, et al: Assessment of clinical criteria for sepsis: For the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 315:762–774. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Kaukonen KM, Bailey M, Pilcher D, Cooper DJ and Bellomo R: Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 372:1629–1638. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Mayr FB, Yende S and Angus DC: Epidemiology of severe sepsis. Virulence. 5:4–11. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Hotchkiss RS, Monneret G and Payen D: Immunosuppression in sepsis: A novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis. 13:260–268. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Su L, Feng L, Song Q, Kang H, Zhang X, Liang Z, Jia Y, Feng D, Liu C and Xie L: Diagnostic value of dynamics serum sCD163, sTREM-1, PCT, and CRP in differentiating sepsis, severity assessment, and prognostic prediction. Mediators Inflamm. 2013:9698752013. View Article : Google Scholar : PubMed/NCBI

18 

Li Z, Wang H, Liu J, Chen B and Li G: Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: A prospective cohort study. Mediators Inflamm. 2014:6410392014. View Article : Google Scholar : PubMed/NCBI

19 

Savva A, Plantinga TS, Kotanidou A, Farcas M, Baziaka F, Raftogiannis M, Orfanos SE, Dimopoulos G, Netea MG and Giamarellos-Bourboulis EJ: Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumonia. Eur J Clin Microbiol Infect Dis. 33:1609–1614. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Ashour FH, Maghraby HM and Hassan AS: Procalcitonin as a diagnostic and prognostic marker of sepsis in critically Ill patients in intensive care unit. Egypt J Hosp Med. 68:2017.

21 

Huo JM, Huo R, Hu L, Lu SW and Zu J: Value of procalcitonin, high sensitivity C-reactive protein and pancreatic stone protein in predicting prognosis of children with sepsis. Sichuan Da Xue Xue Bao Yi Xue Ban. 48:422–426. 2017.(In Chinese). PubMed/NCBI

22 

John J, Chisthi MM and Kuttanchettiyar KG: C-reactive protein: An early predictor of sepsis in patients with thermal burns. Int Surg J. 4:628–632. 2017. View Article : Google Scholar

23 

Franekova J, Kieslichova E, Brezina A, Brodska H, Secnik P and Jabor A: Presepsin can replace procalcitonin in the prediction of sepsis in transplant patients after antithymocyte globulin administration. Clin Chem Lab Med. 53:S5332015.

24 

Sonawane VB, Gaikwad SU, Kadam NN and Gavhane J: Comparative study of diagnostic markers in neonatal sepsis. J Nepal Paediatr Soc. 34:111–114. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Q and Gong X: Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit. Exp Ther Med 15: 4265-4270, 2018.
APA
Li, Q., & Gong, X. (2018). Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit. Experimental and Therapeutic Medicine, 15, 4265-4270. https://doi.org/10.3892/etm.2018.5960
MLA
Li, Q., Gong, X."Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit". Experimental and Therapeutic Medicine 15.5 (2018): 4265-4270.
Chicago
Li, Q., Gong, X."Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4265-4270. https://doi.org/10.3892/etm.2018.5960
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q and Gong X: Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit. Exp Ther Med 15: 4265-4270, 2018.
APA
Li, Q., & Gong, X. (2018). Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit. Experimental and Therapeutic Medicine, 15, 4265-4270. https://doi.org/10.3892/etm.2018.5960
MLA
Li, Q., Gong, X."Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit". Experimental and Therapeutic Medicine 15.5 (2018): 4265-4270.
Chicago
Li, Q., Gong, X."Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4265-4270. https://doi.org/10.3892/etm.2018.5960
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