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Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats

  • Authors:
    • Tongyun He
    • Jianmei Tao
    • Xinqiang Wang
    • Xuena Wang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China, Department of Pharmacy, The First People's Hospital of Huzhou, Huzhou, Zhejiang 313000, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4414-4418
    |
    Published online on: March 20, 2018
       https://doi.org/10.3892/etm.2018.5978
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Abstract

The effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats were investigated. A total of 54 male Sprague‑Dawley rats were selected and divided randomly into three groups: Sham group (n=6), model group (n=24) and experiment group (n=24). Rats in the model and experiment groups underwent cecal ligation and puncture (CLP) for establishment of sepsis model. Rats in experiment group additionally received cisatracurium medication in combination with ventilation for treatment. At 6, 12 and 24 h after CLP, the levels of tumor necrosis factor (TNF)-α, interleukin (IL)‑1β, IL-6 and procalcitonin (PCT) in serum and the ratio of leukocyte to neutrophil in peripheral blood was also detected. Twenty-four hours later, the expression of high mobility group box 1 (HMGB1) in lung tissues and cluster of differentiation (CD) 4+ and CD8+ in T-lymphocyte subsets were also detected, and the wet/dry (W/D) ratio of lung was measured. Compared with that in model group, the levels of inflammatory factors in the experiment group were significantly decreased, while the indicators in assays of cellular immunity were obviously elevated. Ratio of leukocyte to neutrophil in peripheral blood was significantly decreased after treatment. Cisatracurium in combination with ventilation can alleviate the inflammatory injury to organs in sepsis rats through inhibiting the inflammatory responses and regulating the immune functions, which manifests a new significance in guiding the clinical diagnosis and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
He T, Tao J, Wang X and Wang X: Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats. Exp Ther Med 15: 4414-4418, 2018.
APA
He, T., Tao, J., Wang, X., & Wang, X. (2018). Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats. Experimental and Therapeutic Medicine, 15, 4414-4418. https://doi.org/10.3892/etm.2018.5978
MLA
He, T., Tao, J., Wang, X., Wang, X."Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats". Experimental and Therapeutic Medicine 15.5 (2018): 4414-4418.
Chicago
He, T., Tao, J., Wang, X., Wang, X."Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4414-4418. https://doi.org/10.3892/etm.2018.5978
Copy and paste a formatted citation
x
Spandidos Publications style
He T, Tao J, Wang X and Wang X: Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats. Exp Ther Med 15: 4414-4418, 2018.
APA
He, T., Tao, J., Wang, X., & Wang, X. (2018). Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats. Experimental and Therapeutic Medicine, 15, 4414-4418. https://doi.org/10.3892/etm.2018.5978
MLA
He, T., Tao, J., Wang, X., Wang, X."Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats". Experimental and Therapeutic Medicine 15.5 (2018): 4414-4418.
Chicago
He, T., Tao, J., Wang, X., Wang, X."Effects of cisatracurium in combination with ventilation on inflammatory factors and immune variations in sepsis rats". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4414-4418. https://doi.org/10.3892/etm.2018.5978
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