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Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome

  • Authors:
    • Li Guo
    • Lidong Ren
    • Caixia Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Department of Breast, Thyroid, Hernia and Vascular Surgery, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010050, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4436-4440
    |
    Published online on: March 22, 2018
       https://doi.org/10.3892/etm.2018.5985
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Abstract

The relationship of depression with levels of serum inflammatory factors and brain-derived neurotrophic factor (BDNF) in patients with perimenopausal syndrome was analyzed to investigate the predictive values of risk factors for depression in patients with perimenopausal syndrome. A total of 73 patients with perimenopausal syndrome were selected, and divided into the depression (n=30) and non-depression (n=43) groups. Results showed that the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in the depression group were significantly higher than those in the non-depression group (P<0.05). The serum BDNF level in the depression group was significantly lower than that in the non-depression group (P<0.05). The levels of serum inflammatory factors, including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), in depression group were obviously higher than those in non‑depression group (P<0.05). The correlation analyses of serum inflammatory factor and BDNF levels with depression showed that CRP and TNF-α were positively correlated with SDS score, while BDNF level was negatively correlated with SDS score. Logistic regression analyses revealed that menstrual status, chronic diseases, serum inflammatory factors (CRP, IL-6 and TNF-α) and BDNF levels had independent predictive values for depression in patients with perimenopausal syndrome (P<0.05). In conclusion, levels of serum CRP, IL-6, TNF-α and BDNF can be used as judgment indicators for the severity of depression.
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Copy and paste a formatted citation
Spandidos Publications style
Guo L, Ren L and Zhang C: Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Exp Ther Med 15: 4436-4440, 2018.
APA
Guo, L., Ren, L., & Zhang, C. (2018). Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Experimental and Therapeutic Medicine, 15, 4436-4440. https://doi.org/10.3892/etm.2018.5985
MLA
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15.5 (2018): 4436-4440.
Chicago
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4436-4440. https://doi.org/10.3892/etm.2018.5985
Copy and paste a formatted citation
x
Spandidos Publications style
Guo L, Ren L and Zhang C: Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Exp Ther Med 15: 4436-4440, 2018.
APA
Guo, L., Ren, L., & Zhang, C. (2018). Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome. Experimental and Therapeutic Medicine, 15, 4436-4440. https://doi.org/10.3892/etm.2018.5985
MLA
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15.5 (2018): 4436-4440.
Chicago
Guo, L., Ren, L., Zhang, C."Relationship between depression and inflammatory factors and brain-derived neurotrophic factor in patients with perimenopause syndrome". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4436-4440. https://doi.org/10.3892/etm.2018.5985
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