Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients

Li,Xv; Li,Chuantao

doi:10.3892/etm.2018.5987

Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients

Authors:
- Xv Li
- Chuantao Li
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Affiliations: Department of Internal Medicine, Maternity and Child Health Care of Zaozhuang, Zaozhuang, Shandong 277100, P.R. China
Published online on: March 22, 2018 https://doi.org/10.3892/etm.2018.5987
Pages: 4538-4542
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Changes in intestinal flora in obese patients and intravascular C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and coronary heart disease (CHD) were analyzed. A total of 75 cases of obese patients were divided into obesity (OB) alone (n=40) and OB with CHD group (n=35). There was no statistically significant difference in age, sex, pre-existing basic diabetes, history of hypertension, and body mass index (P>0.05). Results showed that total bacterial load of CHD was obviously higher than that of OB group. The uric acid decomposed by intestinal flora (IFUA) and blood uric acid levels in CHD were higher than those in OB group, but the fecal uric acid level was lower than that of OB group (P<0.05). Levels of inflammatory factors in CHD, were significantly higher than those in OB group (P<0.05). Correlation analyses showed that the intestinal flora total load and CRP were positively correlated (r=0.793, P<0.001). Intestinal flora and Gensini score were also positively related to total load (r=0.893, P=0.893). Furthermore, CRP and Gensini score were positively related (r=0.796, P<0.796). IFUA and Gensini score were positively related to (r=0.647, P<0.001). Over-reaction in the flammation system in obese patients may lead to intestinal flora disorder, disturbance and also increased levels of IFUA and inflammatory factors.

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