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Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients

  • Authors:
    • Xv Li
    • Chuantao Li
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Maternity and Child Health Care of Zaozhuang, Zaozhuang, Shandong 277100, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4538-4542
    |
    Published online on: March 22, 2018
       https://doi.org/10.3892/etm.2018.5987
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Abstract

Changes in intestinal flora in obese patients and intravascular C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and coronary heart disease (CHD) were analyzed. A total of 75 cases of obese patients were divided into obesity (OB) alone (n=40) and OB with CHD group (n=35). There was no statistically significant difference in age, sex, pre-existing basic diabetes, history of hypertension, and body mass index (P>0.05). Results showed that total bacterial load of CHD was obviously higher than that of OB group. The uric acid decomposed by intestinal flora (IFUA) and blood uric acid levels in CHD were higher than those in OB group, but the fecal uric acid level was lower than that of OB group (P<0.05). Levels of inflammatory factors in CHD, were significantly higher than those in OB group (P<0.05). Correlation analyses showed that the intestinal flora total load and CRP were positively correlated (r=0.793, P<0.001). Intestinal flora and Gensini score were also positively related to total load (r=0.893, P=0.893). Furthermore, CRP and Gensini score were positively related (r=0.796, P<0.796). IFUA and Gensini score were positively related to (r=0.647, P<0.001). Over-reaction in the flammation system in obese patients may lead to intestinal flora disorder, disturbance and also increased levels of IFUA and inflammatory factors.
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Copy and paste a formatted citation
Spandidos Publications style
Li X and Li C: Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients. Exp Ther Med 15: 4538-4542, 2018.
APA
Li, X., & Li, C. (2018). Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients. Experimental and Therapeutic Medicine, 15, 4538-4542. https://doi.org/10.3892/etm.2018.5987
MLA
Li, X., Li, C."Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients". Experimental and Therapeutic Medicine 15.5 (2018): 4538-4542.
Chicago
Li, X., Li, C."Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4538-4542. https://doi.org/10.3892/etm.2018.5987
Copy and paste a formatted citation
x
Spandidos Publications style
Li X and Li C: Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients. Exp Ther Med 15: 4538-4542, 2018.
APA
Li, X., & Li, C. (2018). Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients. Experimental and Therapeutic Medicine, 15, 4538-4542. https://doi.org/10.3892/etm.2018.5987
MLA
Li, X., Li, C."Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients". Experimental and Therapeutic Medicine 15.5 (2018): 4538-4542.
Chicago
Li, X., Li, C."Analysis of changes in intestinal flora and intravascular inflammation and coronary heart disease in obese patients". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4538-4542. https://doi.org/10.3892/etm.2018.5987
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