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Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)

  • Authors:
    • Yingchen Li
    • Qilai Cheng
    • Guoheng Hu
    • Tianhao Deng
    • Qimei Wang
    • Jianda Zhou
    • Xinping Su
  • View Affiliations / Copyright

    Affiliations: Post‑doctoral Research Station of Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China, Department of Neurology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410007, P.R. China, Department of Oncology, The Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, P.R. China, Department of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Osteology, The Affiliated Hospital of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4067-4079
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    Published online on: March 22, 2018
       https://doi.org/10.3892/etm.2018.5993
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Abstract

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells (MSCs) hold great promise for neurovascular remodeling and neurological function recovery following a stroke. Rather than a direct replacement of parenchymal brain cells, the therapeutic mechanism of MSCs is suggested to be the secretion of soluble factors. Specifically, emerging data described MSCs as being able to release extracellular vesicles (EVs), which contain a variety of cargo including proteins, lipids, DNA and various RNA species. The released EVs can target neurocytes and vascular cells and modify the cell's functions by delivering the cargo, which are considered to mediate the neural restoration effects of MSCs. Therefore, EVs may be developed as a novel cell‑free therapy for neurological disorders. In the present review, the current advances regarding the components, functions and therapeutic potential of EVs are summarized and the use of MSC‑derived EVs as a promising approach in the treatment of stroke are highlighted.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Cheng Q, Hu G, Deng T, Wang Q, Zhou J and Su X: Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review). Exp Ther Med 15: 4067-4079, 2018.
APA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., & Su, X. (2018). Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review). Experimental and Therapeutic Medicine, 15, 4067-4079. https://doi.org/10.3892/etm.2018.5993
MLA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15.5 (2018): 4067-4079.
Chicago
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4067-4079. https://doi.org/10.3892/etm.2018.5993
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Cheng Q, Hu G, Deng T, Wang Q, Zhou J and Su X: Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review). Exp Ther Med 15: 4067-4079, 2018.
APA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., & Su, X. (2018). Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review). Experimental and Therapeutic Medicine, 15, 4067-4079. https://doi.org/10.3892/etm.2018.5993
MLA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15.5 (2018): 4067-4079.
Chicago
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4067-4079. https://doi.org/10.3892/etm.2018.5993
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