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Article Open Access

Potential mechanism and drug candidates for sepsis‑induced acute lung injury

  • Authors:
    • Chenyuan Xu
    • Zhengqiang Guo
    • Chuncheng Zhao
    • Xufeng Zhang
    • Zheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4689-4696
    |
    Published online on: March 28, 2018
       https://doi.org/10.3892/etm.2018.6001
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Abstract

The present study aimed to explore the mechanisms underlying sepsis‑induced acute lung injury (ALI) and identify more effective therapeutic strategies to treat it. The gene expression data set GSE10474 was downloaded and assessed to identify differentially expressed genes (DEGs). Principal component analysis, functional enrichment analysis and differential co‑expression analysis of DEGs were performed. Furthermore, potential target drugs for key DEGs were assessed. A total of 209 DEGs, including 107 upregulated and 102 downregulated genes were screened. A number of DEGs, including zinc finger and BTB domain containing 17 (ZBTB17), heat shock protein 90 kDa β, member 1 (HSP90B1) and major histocompatibility complex, class II, DR α were identified. Furthermore, gene ontology terms including antigen processing and presentation, glycerophospholipid metabolism, transcriptional misregulation in cancer, thyroid hormone synthesis and pathways associated with diseases, such as asthma were identified. In addition, a differential co‑expression network containing ubiquitin‑conjugating enzyme E2 D4, putative and tubulin, γ complex associated protein 3 was constructed. Furthermore, a number of gene‑drug interactions, including between HSP90B1 and adenosine‑5'‑diphosphate and radicicol, were identified. Therefore, DEGs, including ZBTB17 and HSP90B1, may be important in the pathogenesis of sepsis‑induced ALI. Furthermore, drugs including adenosine‑5'‑diphosphate may be novel drug candidates to treat patients with ALI.
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Copy and paste a formatted citation
Spandidos Publications style
Xu C, Guo Z, Zhao C, Zhang X and Wang Z: Potential mechanism and drug candidates for sepsis‑induced acute lung injury. Exp Ther Med 15: 4689-4696, 2018.
APA
Xu, C., Guo, Z., Zhao, C., Zhang, X., & Wang, Z. (2018). Potential mechanism and drug candidates for sepsis‑induced acute lung injury. Experimental and Therapeutic Medicine, 15, 4689-4696. https://doi.org/10.3892/etm.2018.6001
MLA
Xu, C., Guo, Z., Zhao, C., Zhang, X., Wang, Z."Potential mechanism and drug candidates for sepsis‑induced acute lung injury". Experimental and Therapeutic Medicine 15.6 (2018): 4689-4696.
Chicago
Xu, C., Guo, Z., Zhao, C., Zhang, X., Wang, Z."Potential mechanism and drug candidates for sepsis‑induced acute lung injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4689-4696. https://doi.org/10.3892/etm.2018.6001
Copy and paste a formatted citation
x
Spandidos Publications style
Xu C, Guo Z, Zhao C, Zhang X and Wang Z: Potential mechanism and drug candidates for sepsis‑induced acute lung injury. Exp Ther Med 15: 4689-4696, 2018.
APA
Xu, C., Guo, Z., Zhao, C., Zhang, X., & Wang, Z. (2018). Potential mechanism and drug candidates for sepsis‑induced acute lung injury. Experimental and Therapeutic Medicine, 15, 4689-4696. https://doi.org/10.3892/etm.2018.6001
MLA
Xu, C., Guo, Z., Zhao, C., Zhang, X., Wang, Z."Potential mechanism and drug candidates for sepsis‑induced acute lung injury". Experimental and Therapeutic Medicine 15.6 (2018): 4689-4696.
Chicago
Xu, C., Guo, Z., Zhao, C., Zhang, X., Wang, Z."Potential mechanism and drug candidates for sepsis‑induced acute lung injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4689-4696. https://doi.org/10.3892/etm.2018.6001
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