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Article

Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis

  • Authors:
    • Shun‑Li Tian
    • Kai Zhang
    • Peng‑Cheng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Geratology, Tianjin Geriatric Institute, Tianjin 300052, P.R. China, Division of Nephrology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
  • Pages: 5148-5152
    |
    Published online on: March 28, 2018
       https://doi.org/10.3892/etm.2018.6002
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Abstract

Background peripheral arterial disease (PAD) is a common complication in patients undergoing dialysis, which reduces the quality of life and increases the risk of mortality. Recent literature has documented an association between increased visceral fat (VF) content and a proatherogenic factors in end‑stage renal disease. The present study investigated the prevalence of PAD in patients undergoing hemodialysis. PAD was determined as an ankle‑brachial index <0.9. Additionally, VF content was determined using multiple frequency bioelectrical impendence analysis. The nutritional status of the patients was evaluated by subjective global assessment and endothelial function was measured by ultrasonographic brachial artery flow‑mediated dilatation. Patients divided into two groups (malnourished and non‑malnourished) with two further subgroups in each (high VF and low VF content). The prevalence of PAD was identified to be significantly higher in patients with a high VF mass compared with a low VF mass in non‑malnourished patients. PAD was significantly more common in malnourished patients compared with non‑malnourished patients (P<0.01). The presence of PAD in patients undergoing hemodialysis was identified to be significantly correlated with age, diabetes mellitus (DM) status VF content, malnutrition, serum albumin level, diastolic blood pressure and log C‑reactive protein levels. Furthermore, logistic regression analysis determined that age, DM, VF content and malnutrition were significant independent risk factors for PAD in patients undergoing hemodialysis. In conclusion, the results of the present study indicated that obesity and malnutrition act synergistically to increase the risk of PAD in patients undergoing dialysis.
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Copy and paste a formatted citation
Spandidos Publications style
Tian SL, Zhang K and Xu PC: Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis. Exp Ther Med 15: 5148-5152, 2018.
APA
Tian, S., Zhang, K., & Xu, P. (2018). Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis. Experimental and Therapeutic Medicine, 15, 5148-5152. https://doi.org/10.3892/etm.2018.6002
MLA
Tian, S., Zhang, K., Xu, P."Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis". Experimental and Therapeutic Medicine 15.6 (2018): 5148-5152.
Chicago
Tian, S., Zhang, K., Xu, P."Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5148-5152. https://doi.org/10.3892/etm.2018.6002
Copy and paste a formatted citation
x
Spandidos Publications style
Tian SL, Zhang K and Xu PC: Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis. Exp Ther Med 15: 5148-5152, 2018.
APA
Tian, S., Zhang, K., & Xu, P. (2018). Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis. Experimental and Therapeutic Medicine, 15, 5148-5152. https://doi.org/10.3892/etm.2018.6002
MLA
Tian, S., Zhang, K., Xu, P."Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis". Experimental and Therapeutic Medicine 15.6 (2018): 5148-5152.
Chicago
Tian, S., Zhang, K., Xu, P."Increased prevalence of peripheral arterial disease in patients with obese sarcopenia undergoing hemodialysis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5148-5152. https://doi.org/10.3892/etm.2018.6002
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