Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways

  • Authors:
    • Yukang Ying
    • Jun Luo
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Taizhou Central Hospital, Taizhou, Zhejiang 318000, P.R. China
  • Pages: 5041-5045
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/etm.2018.6006
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Salidroside modulates cell proliferation and serves as an anti‑inflammatory and anti‑apoptotic agent with efficacy against various diseases. The objective of the present study was to investigate the efficacy of salidroside in enhancing the proliferation of human periodontal ligament cells (hPDLCs). hPDLCs were isolated and the effects of salidroside on cell viability, soluble osteocalcin levels and activation of proliferation‑associated signaling pathways were determined using a CCK‑8 assay, ELISA and Western blotting, respectively. The results indicated that salidroside induced proliferation of hPDLCs, increased secretion of soluble osteocalcin and enhanced activation of extracellular signal‑regulated kinase (ERK)1/2 and phosphoinositide‑3 kinase (PI3K)/Akt signaling pathways. These factors were upregulated by salidroside in a dose‑dependent manner. The results of the present study suggested that salidroside mediated hPDLC proliferation via the ERK1/2 and PI3K/Akt signaling pathways, as well as osteocalcin secretion. Salidroside may therefore be used as a novel therapeutic agent in the treatment of the tooth‑supporting apparatus, progressive tooth destruction or periodontitis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zhang JK, Yang L, Meng GL, Yuan Z, Fan J, Li D, Chen JZ, Shi TY, Hu HM, Wei BY, et al: Protection by salidroside against bone loss via inhibition of oxidative stress and bone-resorbing mediators. PloS One. 8:e572512013. View Article : Google Scholar : PubMed/NCBI

2 

Song B, Zhou T, Yang WL, Liu J and Shao LQ: Programmed cell death in periodontitis: Recent advances and future perspectives. Oral Dis. 23:609–619. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Qian EW, Ge DT and Kong SK: Salidroside protects human erythrocytes against hydrogen peroxide-induced apoptosis. J Nat Prod. 75:531–537. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Kang C, Yuan M, Wang J, Yuan M and Liu C: Salidroside inhibits clinorotation-induced apoptosis in pulmonary microvascular endothelial cells by regulating signaling pathway of endoplasmic reticulum stress. FASEB J. Suppl 1:302016.

5 

Liu S, Yu X, Hu B, Zou Y, Li J, Bo L and Deng X: Salidroside-rescued mice from experimental sepsis through anti-inflammatory and anti-apoptosis effects. J Surg Res. 195:277–283. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Li D, Fu Y, Zhang W, Su G, Liu B, Guo M, Li F, Liang D, Liu Z, Zhang X, et al: Salidroside attenuates inflammatory responses by suppressing nuclear factor-κB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. Inflamm Res. 62:9–15. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Tang Y, Vater C, Jacobi A, Liebers C, Zou X and Stiehler M: Salidroside exerts angiogenic and cytoprotective effects on human bone marro-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways. Br J Pharmacol. 171:2440–2456. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Chang X, Luo F, Jiang W, Zhu L, Gao J, He H, Wei T, Gong S and Yan T: Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-κB pathway in vivo and in vitro. Int Immunopharmacol. 28:604–615. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y and Jin S: Salidroside stimulates mitochondrial biogenesis and protects against H2O2-induced endothelial dysfunction. Oxid Med Cell Longev. 2014:9048342014. View Article : Google Scholar : PubMed/NCBI

10 

Zhang J, Zhen YF, Pu-Bu-Ci-Ren Song LG, Kong WN, Shao TM, Li X and Chai XQ: Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behav Brain Res. 244:70–81. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Li L, Qu Y, Jin X, Guo XQ, Wang Y, Qi L, Yang J, Zhang P and Li LZ: Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis. Sci Rep. 6:321312016. View Article : Google Scholar : PubMed/NCBI

12 

Liu Z, Li X, Simoneau AR, Jafari M and Zi X: Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 51:257–267. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wang J, Li JZ, Lu AX, Zhang KF and Li BJ: Anticancer effect of salidroside on A549 lung cancer cells through inhibition of oxidative stress and phospho-p38 expression. Oncol Lett. 7:1159–1164. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Di Benedetto A, Gigante I, Colucci S and Grano M: Periodontal disease: Linking the primary inflammation to bone loss. Clin Dev Immunol. 2013:5037542013. View Article : Google Scholar : PubMed/NCBI

15 

Pacios S, Andriankaja O, Kang J, Alnammary M, Bae J, de Brito Bezerra B, Schreiner H, Fine DH and Graves DT: Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. Am J Pathol. 183:1928–1935. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tonetti MS and Van Dyke TE: Working group 1 of the joint EFP/AAP workshop: Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the Joint EFP/AAP workshop on periodontitis and systemic diseases. J Periodontol. 84 4 Suppl:S24–S29. 2013. View Article : Google Scholar

17 

Lee SI, Yi JK, Bae WJ, Lee S, Cha HJ and Kim EC: Thymosin beta-4 suppresses osteoclastic differentiation and inflammatory responses in human periodontal ligament cells. Plos One. 11:e01467082016. View Article : Google Scholar : PubMed/NCBI

18 

Hasegawa M, Yamato M, Kikuchi A, Okano T and Ishikawa I: Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an athymic rat model. Tissue Eng. 11:469–478. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Nagatomo K, Komaki M, Sekiya I, Sakaguchi Y, Noguchi K, Oda S, Muneta T and Ishikawa I: Stem cell properties of human periodontal ligament cells. J Periodontal Res. 41:303–310. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Han J, Meng HX, Tang JM, Li SL, Tang Y and Chen ZB: The effect of different platelet-rich plasma concentrations on proliferation and differentiation of human periodontal ligament cells in vitro. Cell Prolif. 40:241–252. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Xia L, Zhang Z, Chen L, Zhang W, Zeng D, Zhang X, Chang J and Jiang X: Proliferation and osteogenic differentiation of human periodontal ligament cells on akermanite and β-TCP bioceramics. Eur Cell Mater. 22:68–83. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Bonomini S, Crugnola M, Mancini C, Martella E, Ferrari L, Tabilio A and Rizzoli V: The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood. 110:334–338. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Fu X, Tian J, Zhang L, Chen Y and Hao Q: Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells. FEBS Lett. 586:1279–1286. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Lv C, Huang Y, Liu ZX, Yu D and Bai ZM: Salidroside reduces renal cell carcinoma proliferation by inhibiting JAK2/STAT3 signaling. Cancer Biomark. 17:41–47. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Dai J, Peng L, Fan K, Wang H, Wei R, Ji G, Cai J, Lu B, Li B, Zhang D, et al: Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells. Oncogene. 28:3412–3422. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Waseem T, Duxbury M, Ashley SW and Robinson MK: Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation. Peptides. 52:113–121. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Ishii A, Furusho M and Bansal R: Sustained activation of ERK1/2 MAPK in oligodendrocytes and schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion. J Neurosci. 33:175–186. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Yang N, Hui L, Wang Y, Yang H and Jiang X: SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway. Oncol Rep. 31:2651–2659. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S, Markman B, Rodriguez O, Guzman M, Rodriguez S, et al: PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene. 30:2547–2557. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Martin P and Pognonec P: ERK and cell death: Cadmium toxicity, sustained ERK activation and cell death. FEBS J. 277:39–46. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Roux PP and Blenis J: ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 68:320–344. 2004. View Article : Google Scholar : PubMed/NCBI

32 

An S, Huang X, Gao Y, Ling J, Huang Y and Xiao Y: FGF-2 induces the proliferation of human periodontal ligament cells and modulates their osteoblastic phenotype by affecting Runx2 expression in the presence and absence of osteogenic inducers. Int J Mol Med. 36:705–711. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Padial-Molina M, Volk SL and Rios HF: Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor-α and Porphyromonas gingivalis lipopolysaccharides. J Periodontal Res. 49:405–414. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Booth SL, Centi A, Smith SR and Gundberg C: The role of osteocalcin in human glucose metabolism: Marker or mediator? Nat Rev Endocrinol. 9:43–55. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Wei J, Hanna T, Suda N, Karsenty G and Ducy P: Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a. Diabetes. 63:1021–1031. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Chang D, Xu H, Guo Y, Jiang X, Liu Y, Li K, Pan C, Yuan M, Wang J, Li T and Liu C: Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line. In Vitro Cell Dev Biol Anim. 49:170–177. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Kaw A, Fraga D and Fischer C: Effect of osteocalcin on human beta cell proliferation and function and its role on insulin secretion. Pancreatol. 13 Suppl:S642013. View Article : Google Scholar

38 

Gerard K and Ducy PF: Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass. Patent AU2007294732. Filed September 13, 2007; issued April 23. 2009.

39 

Liu J and Yang J: Uncarboxylated osteocalcin inhibits high glucose-induced ROS production and stimulates osteoblastic differentiation by preventing the activation of PI3K/Akt in MC3T3-E1 cells. Int J Mol Med. 37:173–181. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Han Y, Xu G, Zhang J, Yan M, Li X, Ma B, Jun L, Wang SJ and Tan J: Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPK-ERK1/2 signaling pathway. Oncotarget. 7:64021–64029. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ying Y and Luo J: Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways. Exp Ther Med 15: 5041-5045, 2018.
APA
Ying, Y., & Luo, J. (2018). Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways. Experimental and Therapeutic Medicine, 15, 5041-5045. https://doi.org/10.3892/etm.2018.6006
MLA
Ying, Y., Luo, J."Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways". Experimental and Therapeutic Medicine 15.6 (2018): 5041-5045.
Chicago
Ying, Y., Luo, J."Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5041-5045. https://doi.org/10.3892/etm.2018.6006
Copy and paste a formatted citation
x
Spandidos Publications style
Ying Y and Luo J: Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways. Exp Ther Med 15: 5041-5045, 2018.
APA
Ying, Y., & Luo, J. (2018). Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways. Experimental and Therapeutic Medicine, 15, 5041-5045. https://doi.org/10.3892/etm.2018.6006
MLA
Ying, Y., Luo, J."Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways". Experimental and Therapeutic Medicine 15.6 (2018): 5041-5045.
Chicago
Ying, Y., Luo, J."Salidroside promotes human periodontal ligament cell proliferation and osteocalcin secretion via ERK1/2 and PI3K/Akt signaling pathways". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5041-5045. https://doi.org/10.3892/etm.2018.6006
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team