Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage

Zhao,Jianhua; Mao,Qing; Qian,Zhongxin; Zhu,Jun; Qu,Zhun; Wang,Chao

doi:10.3892/etm.2018.6014

June-2018 Volume 15 Issue 6

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June-2018 Volume 15 Issue 6

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Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage

Authors:
- Jianhua Zhao
- Qing Mao
- Zhongxin Qian
- Jun Zhu
- Zhun Qu
- Chao Wang
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, P.R. China, Department of Neurosurgery, Shanghai Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, P.R. China, Department of Neurosurgery, Shanghai Punan Hospital, Shanghai 200127, P.R. China

Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 4906-4910
|
Published online on: March 30, 2018

https://doi.org/10.3892/etm.2018.6014
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Abstract

Mild hypothermia combined with minimally invasive hematoma evacuation was evaluated in the treatment of hypertensive intracerebral hemorrhage to reduce inflammatory response of brain tissue around hematoma and ameliorate brain function, and to investigate its safety, effectiveness and feasibility. A total of 206 patients with acute spontaneous hypertensive intracerebral hemorrhage were collected clinically and randomly divided into minimally invasive hematoma evacuation group (group A) and mild hypothermia combined with minimally invasive hematoma evacuation (group B). The National Institutes of Health Stroke Scale (NIHSS) score was used before and after treatment. Group A was treated with minimally invasive intracranial hematoma evacuation using intracranial hematoma grinding puncture needle while group B received whole body water circulation type cooling blanket plus local cerebral mild hypothermia therapy with ice cap on the basis of minimally invasive surgery. Patients' brain tissue fragments around hematoma taken out with rinsing during operation and at postoperative 1, 3 and 7 days were investigated. The contents of tumor necrosis factor-α (TNF-α) in serum at postoperative 1, 3 and 7 days were evaluated by enzyme-linked immunosorbent assay (ELISA). For the degree of nerve function defect of patients in the two groups, NIHSS score was lower in group B than that in group A at days 3 and 7, and the differences were statistically significant (P<0.05). The serum TNF-α content and expression of nuclear factor-κB (NF-κB) in brain tissue around hematoma reached the peak on the 3rd day. The TNF-α content and NF-κB expression were lower in group B than those in group A at each time‑point (P<0.05). Mild hypothermia combined with minimally invasive hematoma evacuation can reduce the damage of hematoma to the surrounding brain tissue, effectively alleviate inflammatory response and decrease brain tissue injury, thus ameliorating brain function.

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1	Xu Y, Guo J, Liu X, Li J, Wang J and Hou L: Can herbal medicine cause hematoma enlargement of hypertensive intracerebral hemorrhage within 24 hrs time window? A retrospective study of 256 cases from a single center in china. Evid Based Complement Alternat Med. 2015:8687312015. View Article : Google Scholar : PubMed/NCBI
2	Liu L and Yenari MA: Clinical application of therapeutic hypothermia in stroke. Neurol Res. 31:331–335. 2009. View Article : Google Scholar : PubMed/NCBI
3	Kollmar R, Staykov D, Dörfler A, Schellinger PD, Schwab S and Bardutzky J: Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage. Stroke. 41:1684–1689. 2010. View Article : Google Scholar : PubMed/NCBI
4	Broderick JP, Brott TG, Duldner JE, Tomsick T and Huster G: Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality. Stroke. 24:987–993. 1993. View Article : Google Scholar : PubMed/NCBI
5	Schlegel D, Kolb SJ, Luciano JM, Tovar JM, Cucchiara BL, Liebeskind DS and Kasner SE: Utility of the NIH Stroke Scale as a predictor of hospital disposition. Stroke. 34:134–137. 2003. View Article : Google Scholar : PubMed/NCBI
6	Young FB, Weir CJ and Lees KR: GAIN International Trial Steering Committee and Investigators: Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials. Stroke. 36:2187–2192. 2005. View Article : Google Scholar : PubMed/NCBI
7	Abou-Chebl A, Sung G, Barbut D and Torbey M: Local brain temperature reduction through intranasal cooling with the RhinoChill device: Preliminary safety data in brain-injured patients. Stroke. 42:2164–2169. 2011. View Article : Google Scholar : PubMed/NCBI
8	Ma LL, Song L, Yu XD, Yu TX, Liang H and Qiu JX: The clinical study on the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia. Eur Rev Med Pharmacol Sci. 21:1999–2006. 2017.PubMed/NCBI
9	Martin-Schild S, Hallevi H, Shaltoni H, Barreto AD, Gonzales NR, Aronowski J, Savitz SI and Grotta JC: Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: A pilot study of caffeinol and mild hypothermia. J Stroke Cerebrovasc Dis. 18:86–96. 2009. View Article : Google Scholar : PubMed/NCBI
10	Busto R, Dietrich WD, Globus MY, Valdes I, Scheinberg P and Ginsberg MD: Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab. 7:729–738. 1987. View Article : Google Scholar : PubMed/NCBI
11	Tsai MS, Barbut D, Wang H, Guan J, Sun S, Inderbitzen B, Weil MH and Tang W: Intra-arrest rapid head cooling improves post resuscitation myocardial function in comparison with delayed post resuscitation surface cooling. Crit Care Med. 36:434–439. 2008. View Article : Google Scholar : PubMed/NCBI
12	Guan J, Barbut D, Wang H, Li Y, Tsai MS, Sun S, Inderbitzen B, Weil MH and Tang W: A comparison between head cooling begun during cardiopulmonary resuscitation and surface cooling after resuscitation in a pig model of cardiac arrest. Crit Care Med. 36:428–433. 2008. View Article : Google Scholar
13	Nimmo AJ and Vink R: Recent patents in CNS drug discovery: The management of inflammation in the central nervous system. Recent Patents CNS Drug Discov. 4:86–95. 2009. View Article : Google Scholar
14	Werner C and Engelhard K: Pathophysiology of traumatic brain injury. Br J Anaesth. 99:4–9. 2007. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage

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