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Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway

Retraction in: /10.3892/etm.2025.13002
  • Authors:
    • Bin Yan
    • Aikepaer Wubuli
    • Yidong Liu
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang 830028, P.R. China, Department of Orthopaedics, North Hospital of People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang 830011, P.R. China, Department of Orthopaedics, Altai People's Hospital, Urumchi, Xinjiang 836500, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4829-4837
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    Published online on: April 2, 2018
       https://doi.org/10.3892/etm.2018.6021
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Abstract

Osteosarcoma is a common type of human carcinoma, which exhibits a high metastasis and recurrence rate. Previous studies have indicated that long non‑coding RNA phosphatase and tensin homolog pseudogene 1 (lnPTENP1) has tumor suppressive action by modulating PTEN expression in different types of tumor cells. However, the potential mechanism by which lnPTENP1 has an effect in osteosarcoma cells remains elusive. In the present study, the role of lnPTENP1 in osteosarcoma cells was investigated and the possible mechanisms by which it functions were explored. It was revealed that lnPTENP1 transfection significantly inhibited osteosarcoma cell growth, proliferation, migration and invasion. LnPTENP1 transfection also significantly promoted apoptosis in Mg63 cells treated with tunicamycin. Further analysis revealed that lnPTENP1 transfection regulated osteosarcoma cell growth via the PI3K/AKT signaling pathway. In vivo assays revealed that lnPTENP1 transfection significantly inhibited osteosarcoma tumor growth and significantly increased the protein expression and phosphorylation levels of PI3K and AKT. In conclusion, the results of the present study indicated that lnPTENP1 may inhibit osteosarcoma cell growth via the PI3K/AKT signaling pathway, which may be a potential novel target for human osteosarcoma therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Yan B, Wubuli A, Liu Y and Wang X: Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002. Exp Ther Med 15: 4829-4837, 2018.
APA
Yan, B., Wubuli, A., Liu, Y., & Wang, X. (2018). Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002. Experimental and Therapeutic Medicine, 15, 4829-4837. https://doi.org/10.3892/etm.2018.6021
MLA
Yan, B., Wubuli, A., Liu, Y., Wang, X."Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002". Experimental and Therapeutic Medicine 15.6 (2018): 4829-4837.
Chicago
Yan, B., Wubuli, A., Liu, Y., Wang, X."Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4829-4837. https://doi.org/10.3892/etm.2018.6021
Copy and paste a formatted citation
x
Spandidos Publications style
Yan B, Wubuli A, Liu Y and Wang X: Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002. Exp Ther Med 15: 4829-4837, 2018.
APA
Yan, B., Wubuli, A., Liu, Y., & Wang, X. (2018). Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002. Experimental and Therapeutic Medicine, 15, 4829-4837. https://doi.org/10.3892/etm.2018.6021
MLA
Yan, B., Wubuli, A., Liu, Y., Wang, X."Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002". Experimental and Therapeutic Medicine 15.6 (2018): 4829-4837.
Chicago
Yan, B., Wubuli, A., Liu, Y., Wang, X."Long non‑coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3‑kinase/protein kinase B signaling pathway Retraction in /10.3892/etm.2025.13002". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4829-4837. https://doi.org/10.3892/etm.2018.6021
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