Expression and clinical significance of periostin in oral lichen planus

  • Authors:
    • Zhi‑Rui Zhang
    • Li‑Ya Chen
    • Hong‑Yan Qi
    • Shao‑Hua Sun
  • View Affiliations

  • Published online on: April 3, 2018     https://doi.org/10.3892/etm.2018.6029
  • Pages: 5141-5147
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Abstract

Oral lichen planus (OLP) is a chronic inflammatory lesion involving the oral mucosa, which has a high likelihood of progressing to cancer. The present study investigated the periostin expression in the mucosa and serum of patients with OLP and its correlation with serum cytokines. A total of 117 patients with OLP and 110 healthy controls were included in the study. The protein expression of periostin were measured in the OLP and normal oral mucosa by immunohistochemistry. ELISA was performed to measure the serum levels of periostin, tumour necrosis factor‑α (TNF‑α), interleukin (IL)‑6, interferon‑γ (IFN‑γ), IL‑4 and thymic stromal lymphopoietin (TSLP). Compared with the control group the OLP group had a significantly increased number of cases with high periostin expression in the oral mucosa and a significantly increased serum periostin level (P<0.05). Among all 117 OLP subjects, high periostin expression was associated with higher serum IL‑6, TNF‑α, TSLP and tissue mast cell density. High periostin expression was also significantly associated with a lower IFN‑γ/IL‑4 ratio (P<0.05). The present study concluded that periostin expression was increased in the oral mucosa and serum of patients with OLP and was associated with inflammatory response, T helper 2 cytokine‑predominant immune imbalance, increased mast cell count and TSLP. The modulation of periostin may represent an attractive novel therapeutic target.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang ZR, Chen LY, Qi HY and Sun SH: Expression and clinical significance of periostin in oral lichen planus. Exp Ther Med 15: 5141-5147, 2018
APA
Zhang, Z., Chen, L., Qi, H., & Sun, S. (2018). Expression and clinical significance of periostin in oral lichen planus. Experimental and Therapeutic Medicine, 15, 5141-5147. https://doi.org/10.3892/etm.2018.6029
MLA
Zhang, Z., Chen, L., Qi, H., Sun, S."Expression and clinical significance of periostin in oral lichen planus". Experimental and Therapeutic Medicine 15.6 (2018): 5141-5147.
Chicago
Zhang, Z., Chen, L., Qi, H., Sun, S."Expression and clinical significance of periostin in oral lichen planus". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5141-5147. https://doi.org/10.3892/etm.2018.6029