Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors

  • Authors:
    • Lingbin Xu
    • Leiming Xu
    • Haidong Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Ningbo Medical Center Lihuili Eastern Hospital Taipei Medical University Ningbo Medical Center, Ningbo, Zhejiang 315040, P.R. China, Department of Radiology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China
  • Pages: 5029-5034
    |
    Published online on: April 3, 2018
       https://doi.org/10.3892/etm.2018.6030
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to assess the clinical utility of three‑dimensional arterial spin labeling (3D‑ASL) perfusion imaging in discriminating between benign, intermediate and malignant musculoskeletal tumors, as well as to analyze the correlation between tumor blood flow (TBF) and microvessel density (MVD). 3D‑ASL was performed on 44 patients with musculoskeletal tumor using a 3.0‑T magnetic resonance system to obtain TBF values prior to surgery. TBF was independently measured by two radiologists. The TBF values of different groups were compared by one‑way analysis of variance. A receiver operating characteristic (ROC) curve was applied to assess the threshold and diagnostic reliability of TBF. Immunohistochemical staining of tumor specimens was performed using a cluster of differentiation 34 monoclonal antibody to calculate MVD counts. The correlation between TBF and MVD counts was analyzed using correlative analysis. Pathology results for a total of 44 cases were obtained by surgery. Good interobserver agreement was found for the TBF values independently determined by the two radiologists (intra‑class correlation coefficient test, 0.891; P<0.05). TBF and MVD values in the malignant group were significantly higher compared with that of the benign, and intermediate groups. No significant difference was found between the TBF and MVD values of the benign, and intermediate groups. According to the ROC analysis, the area under the curve was largest (0.951) when 45.5 ml/min/100 g was considered as the TBF cut‑off value in the diagnosis. The diagnostic sensitivity and specificity were 90.5 and 100%, respectively. Additionally, a significant positive correlation was found between TBF and MVD (r, 0.784; P<0.05). The results of the present study suggest that 3D‑ASL is valuable in discriminating between benign, intermediate and malignant musculoskeletal tumors. 3D‑ASL may be utilized to evaluate angiogenesis in musculoskeletal tumors in vivo.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Campanacci M: Bone and soft tissue tumours. New York: Springer-Verlag; pp. 199–232. 1999

2 

Weeden S, Grimer RJ, Cannon SR, Taminiau AH and Uscinska BM: European Osteosarcoma, Intergroup: The effect of local recurrence on survival in resected osteosarcoma. Eur J Cancer. 37:39–46. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Marulanda GA, Henderson ER, Johnson DA, Letson GD and Cheong D: Orthopaedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 15:13–20. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Grimer RJ, Taminiau AM and Cannon SR: Surgical Subcommitte of the European Osteosarcoma Intergroup: Surgical outcomes in osteosarcoma. J Bone Joint Surg Br. 84:395–400. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Bradley CJ, Yabroff KR, Dahman B, Feuer EJ, Mariotto A and Brown ML: Productivity costs of cancer mortality in the United States: 2000–2020. J Natl Cancer Inst. 100:1763–1770. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Kransdorf MJ and Murphey MD: Radiologic evaluation of soft-tissue masses: A current perspective. AJR Am J Roentgenol. 175:575–587. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Siegel MJ: Magnetic resonance imaging of musculoskeletal soft tissue masses. Radiol Clin North Am. 39:701–720. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Wang CK, Li CW, Hsieh TJ, Chien SH, Liu GC and Tsai KB: Characteriztion of bone and soft tissue tumors with in vivo 1H-MR spectroscopy: Initial results. Radiology. 232:599–605. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Johansen R, Jensen LR, Rydland J, Goa PE, Kvistad KA, Bathen TF, Axelson DE, Lundgren S and Gribbestad IS: Predicting survival and early clinical response to primary chemotherapy for patients with locally advanced breast cancer using DCE-MRI. J Magn Reson Imaging. 29:1300–1307. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, et al: Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun. 6:60202015. View Article : Google Scholar : PubMed/NCBI

11 

Fukumura D and Jain RK: Imaging angiogenesis and the microenvironment. APMIS. 116:695–715. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Rak JW, St Croix BD and Kerbel RS: Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anticancer Drugs. 6:3–18. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst. 82:4–6. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Weidner N, Folkma J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S and Gasparini G: Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 84:1875–1887. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Flecher CD, Unni KK and Merten F: World Health Organization classification of tumousPathology and genetics of tumors of soft tissue and bone. IARC Press; Lyon: pp. 2–10. 2002

16 

Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature. 407:249–257. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Fukumura D, Duda DG, Munn LL and Jain RK: Tumor microvasculature and microenvironment: Novel insights through intravital imaging in pre-clinical models. Microcirculation. 17:206–225. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Rak JW, St Croix BD and Kerbel RS: Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anticancer Drugs. 6:3–18. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Bose S, Lesser ML, Norton L and Rosen PP: Immunophenotype of intraductal carcinoma. Arch Pathol Lab Med. 120:81–85. 1996.PubMed/NCBI

20 

Gilles R, Zafrani B, Guinebretière JM, Meunier M, Lucidarme O, Tardivon AA, Rochard F, Vanel D, Neuenschwander S and Arriagada R: Ductal carcinoma in situ: MR imaging-histopathologic correlation. Radiology. 196:415–419. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Schlemmer HP, Merkle J, Grobholz R, Jaeger T, Michel MS, Werner A, Rabe J and van Kaick G: Can pre-operative contrast-enhanced dynamic MR imaging for prostate cancer predict microvessel density in prostatectomy specimens? Eur Radiol. 14:309–317. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Marković O, Marisavljević D, Cemerikić V, Vidović A, Perunicić M, Todorović M, Elezović I and Colović M: Expression of VEGF and microvessel density in patients with multiple myeloma: Clinical and prognostic significance. Med Oncol. 25:451–457. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Luczynska E, Gasinska A, Blencharz P, Stelmach A, Jereczek-Fossa BA and Reinfuss M: Value of perfusion CT parameters, microvessl density and VEGF expression in differentiation of benign and malignant prostate tumours. Pol J Pathol. 65:229–236. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Tozer GM: Measuring tumour vascular response to antivascular and antiangiogenic drugs. Br J Radiol. 76:S23–S35. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Li Y, Yang ZG, Chen TW, Chen HJ, Sun JY and Lu YR: Peripheral lung carcinoma: Correlation of angiogenesis and first-pass perfusion parameters of 64-detector row CT. Lung Cancer. 61:44–53. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Gordon Y, Partovi S, Müller-Eschner M, Amarteifio E, Bäuerle T, Weber MA, Kauczor HU and Rengier F: Dynamic contrast-enhanced magnetic resonance imaging: Fundamentals and application to the evaluation of the peripheral perfusion. Cardiovasc Diagn Ther. 4:147–164. 2014.PubMed/NCBI

27 

Loizides A, Peer S, Plaikner M, Djurdjevic T and Gruber H: Perfusion pattern of musculoskeletal masses using contrast-enhanced ultrasound: A helpful tool for characterisation? Eur Radiol. 22:1803–1811. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Wu WC, Wang J, Detre JA, Ratcliffe SJ and Floyd TF: Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI. J Magn Reson Imaging. 28:445–452. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Zhang Z, Meng Q, Gao Z, Cai H, Ye Z and Wu H: Evaluation of angiogenesis of VX2 soft tissue tumor by arterial spin labeling perfusion imaging. Chin J Radiol. 10:1084–1088. 2010.

30 

Bivard A, Krishnamurthy V, Stanwell P, Levi C, Spratt NJ, Davis S and Parsons M: Arterial spin labeling versus bolus-tracking perfusion in hyperacute stroke. Stroke. 45:127–133. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Wolf RL, Wang J, Wang S, Melhem ER, O'Rourke DM, Judy KD and Detre JA: Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla. J Magn Reson Imaging. 22:475–482. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Koizumi S, Sakai N, Kawaji H, Takehara Y, Yamashita S, Sakahara H, Baba S, Hiramatsu H, Sameshima T and Namba H: Pseudo-continuous arterial spin labeling reflects vascular density and differentiates angiomatous meningiomas from non-angiomatous meningiomas. J Neuroonncol. 121:549–556. 2015. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu L, Xu L and Zhu H: Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors . Exp Ther Med 15: 5029-5034, 2018.
APA
Xu, L., Xu, L., & Zhu, H. (2018). Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors . Experimental and Therapeutic Medicine, 15, 5029-5034. https://doi.org/10.3892/etm.2018.6030
MLA
Xu, L., Xu, L., Zhu, H."Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors ". Experimental and Therapeutic Medicine 15.6 (2018): 5029-5034.
Chicago
Xu, L., Xu, L., Zhu, H."Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors ". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5029-5034. https://doi.org/10.3892/etm.2018.6030
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Xu L and Zhu H: Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors . Exp Ther Med 15: 5029-5034, 2018.
APA
Xu, L., Xu, L., & Zhu, H. (2018). Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors . Experimental and Therapeutic Medicine, 15, 5029-5034. https://doi.org/10.3892/etm.2018.6030
MLA
Xu, L., Xu, L., Zhu, H."Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors ". Experimental and Therapeutic Medicine 15.6 (2018): 5029-5034.
Chicago
Xu, L., Xu, L., Zhu, H."Evaluation of three‑dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors ". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5029-5034. https://doi.org/10.3892/etm.2018.6030
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team