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Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

  • Authors:
    • Juanjuan Gai
    • Zhenli Gao
    • Liqiang Song
    • Yongyun Xu
    • Weixin Liu
    • Chuanxin Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Oncology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Computed Tomography, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Joint Surgery, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China
    Copyright: © Gai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5344-5352
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    Published online on: April 23, 2018
       https://doi.org/10.3892/etm.2018.6087
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Abstract

Esophageal cancer is a malignant tumor with a relatively high invasiveness, metastatic potential and worldwide incidence among human cancers. The majority of patients with esophageal cancer are diagnosed in a late tumor stage due to a lack of advanced and sensitive protocols for the diagnosis of patients with early‑stage esophageal cancer. In the current study, contrast‑enhanced computerized tomography (CECT) combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR; CECT‑CNFV) were used to diagnose patients with suspected esophageal cancer. A Chitosan‑Fe3O4‑parceled bispecific antibody targeting FGFR and VEGFR was produced and its affinity to esophageal cancer cells was determined both in vitro and in vivo. A total of 320 patients with suspected esophageal cancer were voluntarily recruited to evaluate the efficacy of CECT‑CNFV in the diagnosis of early‑stage esophageal cancer. All participants were subjected to CT and CECT‑CNFV to detect whether tumors were present in the esophageal area. A Chitosan‑Fe3O4 nanoparticles contrast agent was orally administered at 20 min prior to CT and CECT‑CNFV. The results demonstrated that CECT‑CNFV improved diagnostic sensitivity and provided a novel protocol for the diagnosis of tumors in patients with suspected gastric cancer at an early‑stage. Furthermore, the resolution ratio of images was enhanced by CECT‑CNFV, which enabled the visualization of tiny tumor nodules in esophageal tissue. Clinical data demonstrated that CECT‑CNFV diagnosed 200 patients with suspected early‑stage esophageal cancer and 120 patients as tumor free. In addition, CECT‑CNFV exhibited higher signal enhancement of tumor nodules than CT, suggesting a higher accuracy and accumulation of nanoparticle contrast agent within the tumor nodules of esophageal tissue. Notably, the survival rate of patients with esophageal cancer diagnosed at an early‑stage by CECT‑CNFV was higher than the mean five‑year survival rate (P<0.01). In conclusion, CECT‑CNFV enhanced the sensitivity and accuracy of CT in the diagnosis of early‑stage esophageal cancer. Thus, CECT‑CNFV may improve the accuracy of CT in the diagnosis of mural enhancement in patients with esophageal cancer.
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View References

1 

Findlay JM, Middleton MR and Tomlinson I: A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. Ann Oncol. 26:624–644. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Malik MA, Zargar SA and Mittal B: Role of NQO1 609C>T and NQO2-3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis. Mol Biol Rep. 39:9095–9104. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Chen M, Cai E, Huang J, Yu P and Li K: Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer: A systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 21:1126–1134. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Jacobs M, Macefield RC, Blazeby JM, Korfage IJ, van Berge Henegouwen MI, de Haes HC, Smets EM and Sprangers MA: Systematic review reveals limitations of studies evaluating health-related quality of life after potentially curative treatment for esophageal cancer. Qual Life Res. 22:1787–1803. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Samson P, Robinson C, Bradley J, Lockhart AC, Puri V, Broderick S, Kreisel D, Krupnick AS, Patterson GA, Meyers B and Crabtree T: Neoadjuvant chemotherapy versus chemoradiation prior to esophagectomy: Impact on rate of complete pathologic response and survival in esophageal cancer patients. J Thorac Oncol. 11:2227–2237. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Liao J, Liu R, Shi YJ, Yin LH and Pu YP: Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer. Int J Oncol. 48:2567–2579. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Guo J, Yu X, Gu J, Lin Z, Zhao G, Xu F, Lu C and Ge D: Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer. Tumour Biol. 37:6371–6378. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Pan Z, Mao W, Bao Y, Zhang M, Su X and Xu X: The long noncoding RNA CASC9 regulates migration and invasion in esophageal cancer. Cancer Med. 5:2442–2447. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Shi H, Shi D, Wu Y, Shen Q and Li J: Qigesan inhibits migration and invasion of esophageal cancer cells via inducing connexin expression and enhancing gap junction function. Cancer Lett. 380:184–190. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Schiefer AI, Schoppmann SF and Birner P: Lymphovascular invasion of tumor cells in lymph node metastases has a negative impact on survival in esophageal cancer. Surgery. 160:331–340. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Yokota T, Igaki H, Kato K, Tsubosa Y, Mizusawa J, Katayama H, Nakamura K, Fukuda H and Kitagawa Y: Accuracy of preoperative diagnosis of lymph node metastasis for thoracic esophageal cancer patients from JCOG9907 trial. Int J Clin Oncol. 21:283–288. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Visser E, Leeftink AG, van Rossum PS, Siesling S, van Hillegersberg R and Ruurda JP: Waiting time from diagnosis to treatment has no impact on survival in patients with esophageal cancer. Ann Surg Oncol. 23:2679–2689. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ishigaki M, Maeda Y, Taketani A, Andriana BB, Ishihara R, Wongravee K, Ozaki Y and Sato H: Diagnosis of early-stage esophageal cancer by Raman spectroscopy and chemometric techniques. Analyst. 141:1027–1033. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Kawada S and Imai Y: Diagnosis of esophageal cancer and metastatic lymph node using CT and MRI. Nihon Rinsho. 69 Suppl 6:S174–S181. 2011.(In Japanese).

15 

Freling N, Roele E, Schaefer-Prokop C and Fokkens W: Prediction of deep neck abscesses by contrast-enhanced computerized tomography in 76 clinically suspect consecutive patients. Laryngoscope. 119:1745–1752. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yang DH, Min JJ, Jeong YY, Ahn JS, Kim YK, Cho SH, Chung IJ, Bom HS, Kim HJ and Lee JJ: The combined evaluation of interim contrast-enhanced computerized tomography (CT) and FDG-PET/CT predicts the clinical outcomes and may impact on the therapeutic plans in patients with aggressive non-Hodgkin's lymphoma. Ann Hematol. 88:425–432. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kanat O, O'Neil B and Shahda S: Targeted therapy for advanced gastric cancer: A review of current status and future prospects. World J Gastrointestinal Oncol. 7:401–410. 2015. View Article : Google Scholar

18 

Kakimoto N, Chindasombatjaroen J, Tomita S, Shimamoto H, Uchiyama Y, Hasegawa Y, Kishino M, Murakami S and Furukawa S: Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws: Is it useful? Oral Surg Oral Med Oral Pathol Oral Radiol. 115:104–113. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Mazzei MA, Guerrini S, Mazzei FG, Squitieri Cioffi N, Notaro D, de Donato G, Galzerano G, Sacco P, Setacci F, Volterrani L and Setacci C: Follow-up of endovascular aortic aneurysm repair: Preliminary validation of digital tomosynthesis and contrast enhanced ultrasound in detection of medium- to long-term complications. World J Radiol. 8:530–536. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Schalk S, Demi L, Bouhouch N, Kuenen MPJ, Postema AW, de la Rosette JJMCH, Wijkstra H, Tjalkens TJ and Mischi M: Contrast-enhanced Ultrasound Angiogenesis Imaging by mutual information analysis for prostate cancer localization. IEEE Trans Biomed Eng. 64:661–670. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Shi H, Wang Z, Huang C, Gu X, Jia T, Zhang A, Wu Z, Zhu L, Luo X, Zhao X, et al: A functional ct contrast agent for in vivo imaging of tumor hypoxia. Small. 12:3995–4006. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Wheatley MA, Forsberg F, Dube N, Patel M and Oeffinger BE: Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging. Ultrasound Med Biol. 32:83–93. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Fons P, Gueguen-Dorbes G, Herault JP, Geronimi F, Tuyaret J, Frédérique D, Schaeffer P, Volle-Challier C, Herbert JM and Bono F: Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: This mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs. J Cell Physiol. 230:43–51. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Valesky M, Spang AJ, Fisher GW, Farkas DL and Becker D: Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis. Mol Med. 8:103–112. 2002.PubMed/NCBI

25 

Takahashi O, Komaki R, Smith PD, Jürgensmeier JM, Ryan A, Bekele BN, Wistuba II, Jacoby JJ, Korshunova MV, Biernacka A, et al: Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis. Clin Cancer Res. 18:1641–1654. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Bozec A, Formento P, Lassalle S, Lippens C, Hofman P and Milano G: Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: Antitumour supra-additive effects on human head and neck cancer xenografts. Br J Cancer. 97:65–72. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Yang Z, Lu A, Wong BC, Chen X, Bian Z, Zhao Z, Huang W, Zhang G, Chen H and Xu M: Effect of liposomes on the absorption of water-soluble active pharmaceutical ingredients via oral administration. Curr Pharm Des. 19:6647–6654. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Chen CL, Hu GY, Mei Q, Qiu H, Long GX and Hu GQ: Epidermal growth factor receptor-targeted ultra-small superparamagnetic iron oxide particles for magnetic resonance molecular imaging of lung cancer cells in vitro. Chin Med J (Engl). 125:2322–2328. 2012.PubMed/NCBI

29 

Granja RH, Salerno AG, de Lima AC, Montalvo C, Reche KV, Giannotti FM and Wanschel AC: Liquid chromatography/tandem mass spectrometry method to determine boldenone in bovine liver tissues. J AOAC Int. 97:1476–1480. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Ghantous Y, Naddaf R, Barak M, Abd-Elraziq M and Eln-Naaj Abu I: The role of fine needle aspiration in the diagnosis of parotid gland tumors: Correlation with preoperative computerized tomography tumor size. J Craniofac Surg. 27:e192–e196. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Angelov KG, Vasileva MB, Grozdev KS, Sokolov MB and Todorov G: Clinical and pathological characteristics, and prognostic factors for gastric cancer survival in 155 patients in Bulgaria. Hepatogastroenterology. 61:2421–2424. 2014.PubMed/NCBI

32 

Sawasdikosol S: Detecting tyrosine-phosphorylated proteins by Western blot analysis. Curr Protoc Immunol Chapter. 11:Unit 11 13. 11. 2010.

33 

Dirani M, Nasreddine W, Abdulla F and Beydoun A: Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel. Epilepsy Behav Case Rep. 2:164–166. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kargahi N, Razavi SM, Deyhimi P and Homayouni S: Comparative evaluation of eosinophils in normal mucosa, dysplastic mucosa and oral squamous cell carcinoma with hematoxylin-eosin, Congo red, and EMR1 immunohistochemical staining techniques. Electron Physician. 7:1019–1026. 2015.PubMed/NCBI

35 

Wei R, Guo B and Tan ZM: Application of tumor markers detection in early diagnosis of oral maxillofacial-head and neck carcinomas. Zhonghua Kou Qiang Yi Xue Za Zhi. 43:143–145. 2008.(In Chinese). PubMed/NCBI

36 

Neven P, Brouckaert O, Van Belle V, Vanden Bempt I, Hendrickx W, Cho H, Deraedt K, Van Calster B, Van Huffel S, Moerman P, et al: In early-stage breast cancer, the estrogen receptor interacts with correlation between human epidermal growth factor receptor 2 status and age at diagnosis, tumor grade, and lymph node involvement. J Clin Oncol. 26:1768–1771. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Ebell MH, Culp MB and Radke TJ: A systematic review of symptoms for the diagnosis of ovarian cancer. Am J Prev Med. 50:384–394. 2016. View Article : Google Scholar : PubMed/NCBI

38 

de Moura PM, Hallac R, Kane A and Seaward J: Improving the evaluation of alveolar bone grafts with cone beam computerized tomography. Cleft Palate Craniofac J. 53:57–63. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Fang L, Jingjing L, Ying S, Lan M, Tao W and Nan J: Computerized tomography-guided sphenopalatine ganglion pulsed radiofrequency treatment in 16 patients with refractory cluster headaches: Twelve- to 30-month follow-up evaluations. Cephalalgia. 36:106–112. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Benharroch D, Shvarts S, Jotkowitz A and Shelef I: Computerized tomography scanning and magnetic resonance imaging will terminate the era of the autopsy-a hypothesis. J Cancer. 7:115–120. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Lambert S, Al-Hadithy N, Sewell MD, Hertel R, Südkamp N, Noser H and Kamer L: Computerized tomography based 3D modeling of the clavicle. J Orthop Res. 34:1216–1223. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Kim M, Lee JH, Kim SE, Kang SS and Tae G: Nanosized ultrasound enhanced-contrast agent for in vivo tumor imaging via intravenous injection. ACS Appl Mater Interfaces. 8:8409–8418. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Ding W, Lou C, Qiu J, Zhao Z, Zhou Q, Liang M, Ji Z, Yang S and Xing D: Targeted Fe-filled carbon nanotube as a multifunctional contrast agent for thermoacoustic and magnetic resonance imaging of tumor in living mice. Nanomedicine. 12:235–244. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Wang W, Li J, Liu R, Zhang A and Yuan Z: Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue. Nanoscale Res Lett. 11:4292016. View Article : Google Scholar : PubMed/NCBI

45 

Konduru N, Keller J, Ma-Hock L, Gröters S, Landsiedel R, Donaghey TC, Brain JD, Wohlleben W and Molina RM: Biokinetics and effects of barium sulfate nanoparticles. Part Fibre Toxicol. 11:552014. View Article : Google Scholar : PubMed/NCBI

46 

Liss P, Hansell P, Fasching A and Palm F: Iodinated contrast media inhibit oxygen consumption in freshly isolated proximal tubular cells from elderly humans and diabetic rats: Influence of nitric oxide. Ups J Med Sci. 121:12–16. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Mishra SK, Kumar BS, Khushu S, Tripathi RP and Gangenahalli G: Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles used as MRI contrast agent for biomedical imaging. Contrast Media Mol Imaging. 11:350–361. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Kitoh Y: 5. Inspection of hepatocellular carcinoma 3-contrast for the diagnosis of hepatocellular carcinoma: Techniques of image contrast and the choice of MR contrast agent. Nihon Hoshasen Gijutsu Gakkai Zasshi. 72:441–451. 2016.(In Japanese). View Article : Google Scholar : PubMed/NCBI

49 

Zhang J, Liu J, Wang LM, Li ZY and Yuan Z: Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. J Biophotonics. 10:878–886. 2017. View Article : Google Scholar : PubMed/NCBI

50 

D'Hollander A, Mathieu E, Jans H, Vande Velde G, Stakenborg T, Van Dorpe P, Himmelreich U and Lagae L: Development of nanostars as a biocompatible tumor contrast agent: Toward in vivo SERS imaging. Int J Nanomedicine. 11:3703–3714. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Huang YM, Wang CH, Huang JS, Tsai CS, Yeh KY, Lan YJ, Wu TH, Chang PH, Chang YS and Lai CH: Treatment-associated severe thrombocytopenia affects survival rate in esophageal cancer patients undergoing concurrent chemoradiotherapy. Indian J Cancer. 52:454–460. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gai J, Gao Z, Song L, Xu Y, Liu W and Zhao C: Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer. Exp Ther Med 15: 5344-5352, 2018.
APA
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., & Zhao, C. (2018). Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer. Experimental and Therapeutic Medicine, 15, 5344-5352. https://doi.org/10.3892/etm.2018.6087
MLA
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., Zhao, C."Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer". Experimental and Therapeutic Medicine 15.6 (2018): 5344-5352.
Chicago
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., Zhao, C."Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5344-5352. https://doi.org/10.3892/etm.2018.6087
Copy and paste a formatted citation
x
Spandidos Publications style
Gai J, Gao Z, Song L, Xu Y, Liu W and Zhao C: Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer. Exp Ther Med 15: 5344-5352, 2018.
APA
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., & Zhao, C. (2018). Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer. Experimental and Therapeutic Medicine, 15, 5344-5352. https://doi.org/10.3892/etm.2018.6087
MLA
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., Zhao, C."Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer". Experimental and Therapeutic Medicine 15.6 (2018): 5344-5352.
Chicago
Gai, J., Gao, Z., Song, L., Xu, Y., Liu, W., Zhao, C."Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5344-5352. https://doi.org/10.3892/etm.2018.6087
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