Pantoprazole‑induced acute kidney injury: A case report

Peng,Tao; Hu,Zhao; Zheng,Hongnan; Zhen,Junhui; Ma,Chengjun; Yang,Xiangdong

doi:10.3892/etm.2018.6088

Pantoprazole‑induced acute kidney injury: A case report

Authors:
- Tao Peng
- Zhao Hu
- Hongnan Zheng
- Junhui Zhen
- Chengjun Ma
- Xiangdong Yang
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Affiliations: Department of Nephrology, Shandong University Qilu Hospital, Jinan, Shandong 250012, P.R. China, Department of Nephrology, Jinan Third People's Hospital, Jinan, Shandong 250010, P.R. China, Department of Pathology, Shandong University Qilu Hospital, Jinan, Shandong 250012, P.R. China
Published online on: April 23, 2018 https://doi.org/10.3892/etm.2018.6088
Pages: 5302-5306
Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study reports a case of pantoprazole‑induced acute kidney disease. The patient was diagnosed with acute kidney injury with wide interstitial inflammation and eosinophil infiltration. Following 1 month of glucocorticoid therapy, the patient's serum creatinine and urea nitrogen decreased to within normal ranges. The presentation, clinical course, diagnosis and prognosis of pantoprazole‑induced acute kidney injury are discussed herein to highlight the importance of early and correct diagnosis for good prognosis. Disease characteristics include short‑term increased serum creatinine levels that respond to glucocorticoid treatment. The patient had no history of chronic kidney disease or proteinuria and presented with increased serum creatinine following treatment with pantoprazole. Following the end of pantoprazole treatment, short‑term RRT and long‑term prednisolone was administered, then serum creatinine returned to normal. Pantoprazole‑induced acute kidney injury is commonly misdiagnosed and late diagnosis results in poor patient prognoses. Misdiagnosis leads to the administration of treatments that may exacerbate the condition, so appropriate diagnosis and treatment for pantoprazole‑induced acute kidney injury is necessary.

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