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The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury

  • Authors:
    • Eakkapote Prompunt
    • Jantira Sanit
    • Stephanie Barrère‑Lemaire
    • Joel Nargeot
    • Hannah Noordali
    • Melanie Madhani
    • Sarawut Kumphune
  • View Affiliations / Copyright

    Affiliations: Biomedical Research Unit in Cardiovascular Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand, Department of Physiology, Institute of Functional Genomics, National Centre for Scientific Research, French National Institute of Health and Medical Research, University of Montpellier, 34090 Montpellier, France, Institute of Cardiovascular Sciences, School of Medical and Dental Sciences, University of Birmingham, B15 2TT Birmingham, UK
    Copyright: © Prompunt et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5231-5242
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    Published online on: April 25, 2018
       https://doi.org/10.3892/etm.2018.6097
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Abstract

Protease enzymes generated from injured cells and leukocytes are the primary cause of myocardial cell damage following ischemia/reperfusion (I/R). The inhibition of protease enzyme activity via the administration of particular drugs may reduce injury and potentially save patients' lives. The aim of the current study was to investigate the cardioprotective effects of treatment with recombinant human secretory leukocyte protease inhibitor (rhSLPI) on in vitro and ex vivo models of myocardial I/R injury. rhSLPI was applied to isolated adult rat ventricular myocytes (ARVMs) subjected to simulated I/R and to ex vivo murine hearts prior to I/R injury. Cellular injury, cell viability, reactive oxygen species (ROS) levels, and levels of associated proteins were assessed. The results demonstrated that administration of rhSLPI prior to or during sI/R significantly reduced the death and injury of ARVMs and significantly reduced intracellular ROS levels in ARVMs during H2O2 stimulation. In addition, treatment of ARVMs with rhSLPI significantly attenuated p38 mitogen‑activated protein kinase (MAPK) activation and increased the activation of Akt. Furthermore, pretreatment of ex vivo murine hearts with rhSLPI prior to I/R significantly decreased infarct size, attenuated p38 MAPK activation and increased Akt phosphorylation. The results of the current study demonstrated that treatment with rhSLPI induced a cardioprotective effect and reduced ARVM injury and death, intracellular ROS levels and infarct size. rhSLPI also attenuated p38 MAPK phosphorylation and activated Akt phosphorylation. These results suggest that rhSLPI may be developed as a novel therapeutic strategy of treating ischemic heart disease.
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1 

World Health Organization: World Health Statistics 2008. Geneva: 2008

2 

Writing Group Members, . Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, et al: Heart disease and stroke statistics-2016 update: A report from the american heart association. Circulation. 133:e38–e360. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Jennings RB and Reimer KA: The cell biology of acute myocardial ischemia. Annu Rev Med. 42:225–246. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med. 357:1121–1135. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Epelman S, Liu PP and Mann DL: Role of innate and adaptive immune mechanisms in cardiac injury and repair. Nat Rev Immunol. 15:117–129. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Boudoulas KD and Hatzopoulos AK: Cardiac repair and regeneration: The Rubik's cube of cell therapy for heart disease. Dis Model Mech. 2:344–358. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Jordan JE, Zhao ZQ and Vinten-Johansen J: The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Re. 43:860–878. 1999. View Article : Google Scholar

8 

Kuckleburg CJ and Newman PJ: Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler Thromb Vasc Biol. 33:275–284. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Bouchard D, Morisset D, Bourbonnais Y and Tremblay GM: Proteins with whey-acidic-protein motifs and cancer. Lancet Oncol. 7:167–174. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Majchrzak-Gorecka M, Majewski P, Grygier B, Murzyn K and Cichy J: Secretory leukocyte protease inhibitor (SLPI), a multifunctional protein in the host defense response. Cytokine Growth Factor Rev. 28:79–93. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Moreau T, Baranger K, Dadé S, Dallet-Choisy S, Guyot N and Zani ML: Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family. Biochimie. 90:284–295. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Doumas S, Kolokotronis A and Stefanopoulos P: Anti-inflammatory and antimicrobial roles of secretory leukocyte protease inhibitor. Infect Immun. 73:1271–1274. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Schneeberger S, Hautz T, Wahl SM, Brandacher G, Sucher R, Steinmassl O, Steinmassl P, Wright CD, Obrist P, Werner ER, et al: The effect of secretory leukocyte protease inhibitor (SLPI) on ischemia/reperfusion injury in cardiac transplantation. Am J Transplant. 8:773–782. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark JE, Kobayashi KS, Flavell RA, Eickhoff J, cotton M and Marber MS: The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem. 283:11964–11971. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Kumphune S, Bassi R, Jacquet S, Sicard P, Clark JE, Verma S, Avkiran M, O'Keefe SJ and Marber MS: A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. J Biol Chem. 285:2968–2975. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Cowan B, Baron O, Crack J, Coulber C, Wilson GJ and Rabinovitch M: Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation. J Clin Invest. 97:2452–2468. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Tiefenbacher CP, Ebert M, Niroomand F, Batkai S, Tillmanns H, Zimmermann R and Kübler W: Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart. Pflugers Arch. 433:563–570. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Hoffmeyer MR, Scalia R, Ross CR, Jones SP and Lefer DJ: PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol. 279:H2824–H2828. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Ueno M, Moriyama Y, Toda R, Yotsumoto G, Yamamoto H, Fukumoto Y, Sakasegawa K, Nakamura K and Sakata R: Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemia/reperfusion injury using the left-sided heterotopic canine heart transplantation model. J Heart Lung Transplant. 20:889–896. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Schneeberger S, Brandacher G, Mark W, Amberger A and Margreiter R: Protease inhibitors as a potential target in modulation of postischemic inflammation. Drug News Perspect. 15:568–574. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Lentsch AB, Yoshidome H, Warner RL, Ward PA and Edwards MJ: Secretory leukocyte protease inhibitor in mice regulates local and remote organ inflammatory injury induced by hepatic ischemia/reperfusion. Gastroenterology. 117:953–961. 1999. View Article : Google Scholar : PubMed/NCBI

22 

McKiernan PJ, McElvaney NG and Greene CM: SLPI and inflammatory lung disease in females. Biochem Soc Trans. 39:1421–1426. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Ding A, Thieblemont N, Zhu J, Jin F, Zhang J and Wright S: Secretory leukocyte protease inhibitor interferes with uptake of lipopolysaccharide by macrophages. Infect Immun. 67:4485–4489. 1999.PubMed/NCBI

24 

Taggart CC, Cryan SA, Weldon S, Gibbons A, Greene CM, Kelly E, Low TB, O'neill SJ and McElvaney NG: Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med. 202:1659–1668. 2005. View Article : Google Scholar : PubMed/NCBI

25 

McElvaney NG, Nakamura H, Birrer P, Hébert CA, Wong WL, Alphonso M, Baker JB, Catalano MA and Crystal RG: Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest. 90:1296–1301. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Adapala VJ, Buhman KK and Ajuwon KM: Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet. J Inflamm (Lond). 8:52011. View Article : Google Scholar : PubMed/NCBI

27 

Mueller AM, Pedré X, Stempfl T, Kleiter I, Couillard-Despres S, Aigner L, Giegerich G and Steinbrecher A: Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. J Neuroinflammation. 5:202008. View Article : Google Scholar : PubMed/NCBI

28 

McGarry N, Greene CM, McElvaney NG, Weldon S and Taggart CC: The ability of secretory leukocyte protease inhibitor to inhibit apoptosis in monocytes is independent of its antiprotease activity. J Immunol Res. 2015:5073152015. View Article : Google Scholar : PubMed/NCBI

29 

Subramaniyam D, Hollander C, Westin U, Erjefält J, Stevens T and Janciauskiene S: Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis. Respirology. 16:300–307. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Seto T, Takai T, Ebihara N, Matsuoka H, Wang XL, Ishii A, Ogawa H, Murakami A and Okumura K: SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. Biochem Biophys Res Commun. 379:681–685. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Lee SY, Nho TH, Choi BD, Jeong SJ, Lim DS and Jeong MJ: Secretory leukocyte protease inhibitor reduces inflammation and alveolar bone resorption in LPS-induced periodontitis in rats and in MC3T3-E1 preosteoblasts. Animal Cells Systems. 20:344–352. 2016. View Article : Google Scholar

32 

Hoffman JW Jr, Gilbert TB, Poston RS and Silldorff EP: Myocardial reperfusion injury: Etiology, mechanisms, and therapies. J Extra Corpor Technol. 36:391–411. 2004.PubMed/NCBI

33 

Raedschelders K, Ansley DM and Chen DD: The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther. 133:230–255. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Gottlieb RA: Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 16:233–238. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Lucchesi BR: Myocardial ischemia, reperfusion and free radical injury. Am J Cardiol. 65:14I–23I. 1990. View Article : Google Scholar : PubMed/NCBI

36 

Venardos KM, Perkins A, Headrick J and Kaye DM: Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: A review. Curr Med Chem. 14:1539–1549. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Hausenloy DJ and Yellon DM: Myocardial ischemia-reperfusion injury: A neglected therapeutic target. J Clin Invest. 123:92–100. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Ferrari R, Agnoletti L, Comini L, Gaia G, Bachetti T, Cargnoni A, Ceconi C, Curello S and Visioli O: Oxidative stress during myocardial ischaemia and heart failure. Eur Heart J. 19 Suppl B:B2–B11. 1998.PubMed/NCBI

39 

Gillissen A, Birrer P and McElvaney NG: Recombinant secretory leukoprotease inhibitor augments glutathione levels in lung epithelial lining fluid. J Appl Physiol (1985). 75:825–832. 1993. View Article : Google Scholar : PubMed/NCBI

40 

Masterson CH, O'Toole DP and Laffey JP: Over expression of secretory leukocyte protease inhibitor (SLPI) and glutathione peroxidase-3 (GPX3) attenuate inflammation and oxidant-mediated pulmonary epithelial injuryAmerican Thoracic Society 2012 International Conference. San Francisco, California: 2012

41 

Kaiser RA, Lyons JM, Duffy JY, Wagner CJ, McLean KM, O'Neill TP, Pearl JM and Molkentin JD: Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 289:H2747–H2751. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Gorog DA, Tanno M, Cao X, Bellahcene M, Bassi R, Kabir AM, Dighe K, Quinlan RA and Marber MS: Inhibition of p38 MAPK activity fails to attenuate contractile dysfunction in a mouse model of low-flow ischemia. Cardiovasc Res. 61:123–131. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Ma XL, Kumar S, Gao F, Louden CS, Lopez BL, Christopher TA, Wang C, Lee JC, Feuerstein GZ and Yue TL: Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion. Circulation. 99:1685–1691. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Kumphune S, Chattipakorn S and Chattipakorn N: Role of p38 inhibition in cardiac ischemia/reperfusion injury. Eur J Clin Pharmacol. 68:513–524. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Kumphune S, Surinkaew S, Chattipakorn SC and Chattipakorn N: Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury. Pharm Biol. 53:1831–1841. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Yu L, Li F, Zhao G, Yang Y, Jin Z, Zhai M, Yu W, Zhao L, Chen W, Duan W and Yu S: Protective effect of berberine against myocardial ischemia reperfusion injury: Role of Notch1/Hes1-PTEN/Akt signaling. Apoptosis. 20:796–810. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Mullonkal CJ and Toledo-Pereyra LH: Akt in ischemia and reperfusion. J Invest Surg. 20:195–203. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Fujio Y, Nguyen T, Wencker D, Kitsis RN and Walsh K: Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 101:660–667. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Armstrong SC: Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res. 61:427–436. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Surinkaew S, Kumphune S, Chattipakorn S and Chattipakorn N: Inhibition of p38 MAPK during ischemia, but not reperfusion, effectively attenuates fatal arrhythmia in ischemia/reperfusion heart. J Cardiovasc Pharmacol. 61:133–141. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Wu SZ, Tao LY, Wang JN, Xu ZQ, Wang J, Xue YJ, Huang KY, Lin JF, Li L and Ji KT: Amifostine pretreatment attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis and oxidative stress. Oxid Med Cell Longev. 2017:41308242017. View Article : Google Scholar : PubMed/NCBI

52 

Zhang P, Liu X, Huang G, Bai C, Zhang Z and Li H: Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK. Biochem Biophys Res Commun. 490:1215–1220. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Jones SP, Trocha SD and Lefer DJ: Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion. Arterioscler Thromb Vasc Biol. 21:2059–2064. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Chen H, Liu S, Liu X, Yang J, Wang F, Cong X and Chen X: lysophosphatidic acid pretreatment attenuates myocardial ischemia/reperfusion injury in the immature hearts of rats. Front Physiol. 8:1532017. View Article : Google Scholar : PubMed/NCBI

55 

Ke Z, Liu J, Xu P, Gao A, Wang L and Ji L: The cardioprotective effect of icariin on ischemia-reperfusion injury in isolated rat heart: Potential involvement of the PI3K-Akt signaling pathway. Cardiovasc Ther. 33:134–140. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Skrzypiec-Spring M, Grotthus B, Szelag A and Schulz R: Isolated heart perfusion according to Langendorff-still viable in the new millennium. J Pharmacol Toxicol Methods. 55:113–126. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Herr DJ, Aune SE and Menick DR: Induction and assessment of ischemia-reperfusion injury in langendorff-perfused rat hearts. J Vis Exp. 27:e529082015.

58 

Csonka C, Kupai K, Kocsis GF, Novák G, Fekete V, Bencsik P, Csont T and Ferdinandy P: Measurement of myocardial infarct size in preclinical studies. J Pharmacol Toxicol Methods. 61:163–170. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Prompunt E, Sanit J, Barrère‑Lemaire S, Nargeot J, Noordali H, Madhani M and Kumphune S: The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury. Exp Ther Med 15: 5231-5242, 2018.
APA
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., & Kumphune, S. (2018). The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 15, 5231-5242. https://doi.org/10.3892/etm.2018.6097
MLA
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., Kumphune, S."The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury". Experimental and Therapeutic Medicine 15.6 (2018): 5231-5242.
Chicago
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., Kumphune, S."The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5231-5242. https://doi.org/10.3892/etm.2018.6097
Copy and paste a formatted citation
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Spandidos Publications style
Prompunt E, Sanit J, Barrère‑Lemaire S, Nargeot J, Noordali H, Madhani M and Kumphune S: The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury. Exp Ther Med 15: 5231-5242, 2018.
APA
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., & Kumphune, S. (2018). The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 15, 5231-5242. https://doi.org/10.3892/etm.2018.6097
MLA
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., Kumphune, S."The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury". Experimental and Therapeutic Medicine 15.6 (2018): 5231-5242.
Chicago
Prompunt, E., Sanit, J., Barrère‑Lemaire, S., Nargeot, J., Noordali, H., Madhani, M., Kumphune, S."The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5231-5242. https://doi.org/10.3892/etm.2018.6097
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