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Article

Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial

  • Authors:
    • Jian Zhang
    • Kui Shi
    • Hongfeng Jia
  • View Affiliations / Copyright

    Affiliations: Department of Anaesthesiology, Yan An Traditional Chinese Medicine, Yanan, Shanxi 716000, P.R. China, Department of Anaesthesiology, Hanzhong Hospital of Traditional Chinese Medicine, Hanzhong, Shanxi 723001, P.R. China, Department of Anaesthesiology, 3201 Hospital Affiliated to Xi'an Jiaotong University Health Science Center, Xi'An, Shanxi 723000, P.R. China
  • Pages: 5537-5543
    |
    Published online on: April 27, 2018
       https://doi.org/10.3892/etm.2018.6104
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Abstract

Total knee arthroplasty (TKA) is highly associated with post‑operative pain. The present randomized trial aimed to explore the possible post‑operative pain management by a different combination of analgesics or opioids (ketamine and bupivacaine) following TKA. A total of 84 patients were randomly divided into four groups. All subjects were anesthetized for TKA surgery and received post‑operative pain management via intra‑articular saline (control group; n=23), ketamine (2 mg/kg) infused with saline (ket group; n=21) bupivacaine (0.5 mg/kg) infused with saline (bupi group; n=20) or ketamine (2 mg/kg)+bupivacaine (0.5 mg/kg) infused with saline (ket+bupi group; n=20) at the end of the surgery. Additional, post‑operative analgesia was infused with the aid of patient‑controlled analgesia with morphine. A reduction in the levels of pain score (verbal rating scale and visual analog scale), opioid consumption, time of ambulation, hospital stay and adverse events were observed in the ket+bupi group compared with the other groups. Meanwhile, the satisfaction score and knee flexion degree were improved following treatment with the ket+bupi regimen. Therefore, the multimodal analgesic regimen (ket+bupi) may be useful in mitigating post‑operative pain as and improving knee mobilization following TKA.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Shi K and Jia H: Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial. Exp Ther Med 15: 5537-5543, 2018.
APA
Zhang, J., Shi, K., & Jia, H. (2018). Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial. Experimental and Therapeutic Medicine, 15, 5537-5543. https://doi.org/10.3892/etm.2018.6104
MLA
Zhang, J., Shi, K., Jia, H."Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial". Experimental and Therapeutic Medicine 15.6 (2018): 5537-5543.
Chicago
Zhang, J., Shi, K., Jia, H."Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5537-5543. https://doi.org/10.3892/etm.2018.6104
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Shi K and Jia H: Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial. Exp Ther Med 15: 5537-5543, 2018.
APA
Zhang, J., Shi, K., & Jia, H. (2018). Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial. Experimental and Therapeutic Medicine, 15, 5537-5543. https://doi.org/10.3892/etm.2018.6104
MLA
Zhang, J., Shi, K., Jia, H."Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial". Experimental and Therapeutic Medicine 15.6 (2018): 5537-5543.
Chicago
Zhang, J., Shi, K., Jia, H."Ketamine and bupivacaine attenuate post‑operative pain following total knee arthroplasty: A randomized clinical trial". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5537-5543. https://doi.org/10.3892/etm.2018.6104
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