Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis

  • Authors:
    • Liang Xu
    • Yanchun Chen
    • Yanni Ji
    • Song Yang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Disease, Yixing People's Hospital, Yixing, Jiangsu 214200, P.R. China
  • Pages: 5275-5280
    |
    Published online on: May 2, 2018
       https://doi.org/10.3892/etm.2018.6114
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Factors influencing N‑terminal pro‑brain natriuretic peptide (NT‑proBNP) level in heart failure patients with different cardiac functions were identified to explore the correlations with prognosis. Eighty heart failure patients with different cardiac functions treated in Yixing People's Hospital from January 2016 to June 2017 were selected, and divided into two groups (group with cardiac function in class Ⅱ and below and group with cardiac function in class Ⅲ and above), according to the cardiac function classification established by New York Heart Association (NYHA). Blood biochemical test and outcome analysis were conducted to measure serum NT‑proBNP and matrix metalloproteinase‑9 (MMP‑9) levels in patients with different cardiac functions, and correlations between levels of NT‑proBNP and MMP‑9 and left ventricular ejection fraction (LVEF) level were analyzed in patients with different cardiac functions at the same time. In addition, risk factors for heart failure in patients with different cardiac functions were analyzed. Compared with the group with cardiac function in class Ⅲ and above, the group with cardiac function in class Ⅱ and below had significantly lower serum NT‑proBNP and MMP‑9 levels (p<0.05). For echocardiogram indexes, left ventricular end‑diastolic diameter (LVEDD) and left ventricular end‑systolic diameter (LVESD) in the group with cardiac function in class Ⅱ and below were obviously lower than those in the group with cardiac function in class Ⅲ and above (p<0.05), while LVEF was higher in group with cardiac function in class Ⅱ and below than that in group with cardiac function in class Ⅲ and above (p<0.05). NT‑proBNP and MMP‑9 levels were negatively correlated with LVEF level [r=‑0.8517 and ‑0.8517, respectively, p<0.001 (<0.05)]. Cardiac function in class Ⅲ and above, increased NT‑proBNP, increased MMP‑9 and decreased LVEF were relevant risk factors and independent risk factors for heart failure in patients with different cardiac functions. NT‑proBNP and MMP‑9 levels are negatively correlated with LVEF in patients regardless of the cardiac function class. Therefore, attention should be paid to patients who have cardiac function in class Ⅲ and above, increased NT‑proBNP and MMP‑9 levels and decreased LVEF in clinical practices, so as to actively prevent and treat heart failure.
View Figures

Figure 1

Figure 2

View References

1 

Isah IA, Sadoh WE and Iduoriyekemwen NJ: Usefulness of amino terminal pro-B-type natriuretic peptide in evaluating children with cardiac failure. Cardiovasc Diagn Ther. 7:380–388. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Raedle-Hurst T, Mueller M, Meinitzer A, Maerz W and Dschietzig T: Homoarginine-A prognostic indicator in adolescents and adults with complex congenital heart disease? PLoS One. 12:e01843332017. View Article : Google Scholar : PubMed/NCBI

3 

Darkner S, Goetze JP, Chen X, Henningsen K, Pehrson S and Svendsen JH: Natriuretic propeptides as markers of atrial fibrillation burden and recurrence (from the AMIO-CAT Trial). Am J Cardiol. 120:1309–1315. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Jiang R, Zhao QH, Wu WH, Zhang R, Yuan P, Gong SG, He J, Luo CJ, Qiu HL, Wang L, et al: Efficacy and safety of a calcium sensitizer, levosimendan, in patients with right heart failure due to pulmonary hypertension. Clin Respir J. 12:1518–1525. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Yu J, Oh PC, Kim M, Moon J, Park YM, Lee K, Suh SY, Han SH, Byun K, Ahn T, et al: Improved early risk stratification of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum soluble ST2 and NT-proBNP. PLoS One. 12:e01828292017. View Article : Google Scholar : PubMed/NCBI

6 

Yan AT, Yan RT, Spinale FG, Afzal R, Gunasinghe HR, Arnold M, Demers C, McKelvie RS and Liu PP: Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure. J Card Fail. 12:514–519. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Vorovich EE, Chuai S, Li M, Averna J, Marwin V, Wolfe D, Reilly MP and Cappola TP: Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Am Heart J. 155:992–997. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Raphael C, Briscoe C, Davies J, Whinnett Ian Z, Manisty C, Sutton R, Mayet J and Francis DP: Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure. Heart. 93:476–482. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Chang KW, Fox S, Mojaver S and Maisel AS: Using biomarkers to guide heart failure management. Expert Rev Cardiovasc Ther. 15:729–741. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Felker GM, Anstrom KJ, Adams KF, Ezekowitz JA, Fiuzat M, Houston-Miller N, Januzzi JL Jr, Mark DB, Piña IL, Passmore G, et al: Effect of natriuretic peptide-guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction: A randomized clinical trial. JAMA. 318:713–720. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Dai Y, Yang J, Takagi A, Konishi H, Miyazaki T, Masuda H, Shimada K, Miyauchi K and Daida H: In-hospital and long-term outcomes of congestive heart failure: Predictive value of B-type and amino-terminal pro-B-type natriuretic peptides and their ratio. Exp Ther Med. 14:1715–1721. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Clerico A, Zaninotto M, Passino C and Plebani M: New issues on measurement of B-type natriuretic peptides. Clin Chem Lab Med. 56:32–39. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Mozzini C, Di Dio Perna M, Pesce G, Garbin U, Pasini Fratta AM, Ticinesi A, Nouvenne A, Meschi T, Casadei A, Soresi M, et al: Lung ultrasound in internal medicine efficiently drives the management of patients with heart failure and speeds up the discharge time. Intern Emerg Med. 13:27–33. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Kang CK, Pope M, Lang CC and Kalra PR: Iron deficiency in heart failure: Efficacy and safety of intravenous iron therapy. Cardiovasc Ther. 35:59–62. 2017. View Article : Google Scholar

15 

Shou X, Lin J, Xie C, Wang Y and Sun C: Plasma IL-37 elevated in patients with chronic heart failure and predicted major adverse cardiac events: A 1-year follow-up study. Dis Markers. 2017:91340792017. View Article : Google Scholar : PubMed/NCBI

16 

Iacoviello L, Bonaccio M, Di Castelnuovo A, Costanzo S, Rago L, De Curtis A, Assanelli D, Badilini F, Vaglio M, Persichillo M, et al: Moli-sani study Investigators: Frontal plane T-wave axis orientation predicts coronary events: Findings from the Moli-sani study. Atherosclerosis. 264:51–57. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Luedde M, Winkler T, Heinsen FA, Rühlemann MC, Spehlmann ME, Bajrovic A, Lieb W, Franke A, Ott SJ and Frey N: Heart failure is associated with depletion of core intestinal microbiota. ESC Heart Fail. 4:282–290. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Toma M, Mak GJ, Chen V, Hollander Z, Shannon CP, Lam KKY, Ng RT, Tebbutt SJ, Wilson-McManus JE, Ignaszewski A, et al: Differentiating heart failure phenotypes using sex-specific transcriptomic and proteomic biomarker panels. ESC Heart Fail. 4:301–311. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Darche FF, Baumgärtner C, Biener M, Müller-Hennessen M, Vafaie M, Koch V, Stoyanov K, Rivinius R, Katus HA and Giannitsis E: Comparative accuracy of NT-proBNP and MR-proANP for the diagnosis of acute heart failure in dyspnoeic patients. ESC Heart Fail. 4:232–240. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Medvedeva EA, Berezin II and Shchukin YV: Galectin-3, markers of oxidative stress and renal dysfunction in patients with chronic heart failure. Kardiologiia. 57:46–50. 2017.(In Russian). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu L, Chen Y, Ji Y and Yang S: Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis. Exp Ther Med 15: 5275-5280, 2018.
APA
Xu, L., Chen, Y., Ji, Y., & Yang, S. (2018). Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis. Experimental and Therapeutic Medicine, 15, 5275-5280. https://doi.org/10.3892/etm.2018.6114
MLA
Xu, L., Chen, Y., Ji, Y., Yang, S."Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis". Experimental and Therapeutic Medicine 15.6 (2018): 5275-5280.
Chicago
Xu, L., Chen, Y., Ji, Y., Yang, S."Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5275-5280. https://doi.org/10.3892/etm.2018.6114
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Chen Y, Ji Y and Yang S: Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis. Exp Ther Med 15: 5275-5280, 2018.
APA
Xu, L., Chen, Y., Ji, Y., & Yang, S. (2018). Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis. Experimental and Therapeutic Medicine, 15, 5275-5280. https://doi.org/10.3892/etm.2018.6114
MLA
Xu, L., Chen, Y., Ji, Y., Yang, S."Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis". Experimental and Therapeutic Medicine 15.6 (2018): 5275-5280.
Chicago
Xu, L., Chen, Y., Ji, Y., Yang, S."Influencing factors of NT‑proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis". Experimental and Therapeutic Medicine 15, no. 6 (2018): 5275-5280. https://doi.org/10.3892/etm.2018.6114
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team